A \textlessspan style="font-variant:small-caps;"\textgreatermeta‐analysis\textless/span\textgreaterof deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the \textlessspan style="font-variant:small-caps;"\textgreater\ENIGMA\

A \textlessspan style="font-variant:small-caps;"\textgreatermeta‐analysis\textless/span\textgreaterof deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the \textlessspan style="font-variant:small-caps;"\textgreater\ENIGMA\ . Gutman, B. A, Van Erp, T. G M, Alpert, K., Ching, C. R K, Isaev, D., Ragothaman, A., Jahanshad, N., Saremi, A., Zavaliangos‐Petropulu, A., Glahn, D. C, Shen, L., Cong, S., Alnæs, D., Andreassen, O. A., Doan, N. T., Westlye, L. T, Kochunov, P., Satterthwaite, T. D, Wolf, D. H, Huang, A. J, Kessler, C., Weideman, A., Nguyen, D., Mueller, B. A, Faziola, L., Potkin, S. G, Preda, A., Mathalon, D. H, Bustillo, J., Calhoun, V., Ford, J. M, Walton, E., Ehrlich, S., Ducci, G., Banaj, N., Piras, F., Piras, F., Spalletta, G., Canales‐Rodríguez, E. J, Fuentes‐Claramonte, P., Pomarol‐Clotet, E., Radua, J., Salvador, R., Sarró, S., Dickie, E. W, Voineskos, A., Tordesillas‐Gutiérrez, D., Crespo‐Facorro, B., Setién‐Suero, E., Van Son, J. M., Borgwardt, S., Schönborn‐Harrisberger, F., Morris, D., Donohoe, G., Holleran, L., Cannon, D., McDonald, C., Corvin, A., Gill, M., Filho, G. B., Rosa, P. G P, Serpa, M. H, Zanetti, M. V, Lebedeva, I., Kaleda, V., Tomyshev, A., Crow, T., James, A., Cervenka, S., Sellgren, C. M, Fatouros‐Bergman, H., Agartz, I., Howells, F., Stein, D. J, Temmingh, H., Uhlmann, A., De Zubicaray, G. I, McMahon, K. L, Wright, M., Cobia, D., Csernansky, J. G, Thompson, P. M, Turner, J. A, & Wang, L. Human Brain Mapping, 43(1):352–372, jan, 2022.
$A \textlessspan style="font-variant:small-caps;"\textgreatermeta‐analysis\textless/span\textgreaterof deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the \textlessspan style="font-variant:small-caps;"\textgreater\ENIGMA\ [link]$ Paper doi abstract bibtex

Abstract Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta‐analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1‐weighted structural MRI scans. Mass univariate meta‐analyses revealed more‐concave‐than‐convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more‐convex‐than‐concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta‐analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.

@article{gutman_span_2022,
abstract = {Abstract
Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta‐analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1‐weighted structural MRI scans. Mass univariate meta‐analyses revealed more‐concave‐than‐convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more‐convex‐than‐concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta‐analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.},
author = {Gutman, Boris A and {Van Erp}, Theo G M and Alpert, Kathryn and Ching, Christopher R K and Isaev, Dmitry and Ragothaman, Anjani and Jahanshad, Neda and Saremi, Arvin and Zavaliangos‐Petropulu, Artemis and Glahn, David C and Shen, Li and Cong, Shan and Aln{\ae}s, Dag and Andreassen, Ole Andreas and Doan, Nhat Trung and Westlye, Lars T and Kochunov, Peter and Satterthwaite, Theodore D and Wolf, Daniel H and Huang, Alexander J and Kessler, Charles and Weideman, Andrea and Nguyen, Dana and Mueller, Bryon A and Faziola, Lawrence and Potkin, Steven G and Preda, Adrian and Mathalon, Daniel H and Bustillo, Juan and Calhoun, Vince and Ford, Judith M and Walton, Esther and Ehrlich, Stefan and Ducci, Giuseppe and Banaj, Nerisa and Piras, Fabrizio and Piras, Federica and Spalletta, Gianfranco and Canales‐Rodr{\'{i}}guez, Erick J and Fuentes‐Claramonte, Paola and Pomarol‐Clotet, Edith and Radua, Joaquim and Salvador, Raymond and Sarr{\'{o}}, Salvador and Dickie, Erin W and Voineskos, Aristotle and Tordesillas‐Guti{\'{e}}rrez, Diana and Crespo‐Facorro, Benedicto and Seti{\'{e}}n‐Suero, Esther and {Van Son}, Jacqueline Mayoral and Borgwardt, Stefan and Sch{\"{o}}nborn‐Harrisberger, Fabienne and Morris, Derek and Donohoe, Gary and Holleran, Laurena and Cannon, Dara and McDonald, Colm and Corvin, Aiden and Gill, Michael and Filho, Geraldo Busatto and Rosa, Pedro G P and Serpa, Mauricio H and Zanetti, Marcus V and Lebedeva, Irina and Kaleda, Vasily and Tomyshev, Alexander and Crow, Tim and James, Anthony and Cervenka, Simon and Sellgren, Carl M and Fatouros‐Bergman, Helena and Agartz, Ingrid and Howells, Fleur and Stein, Dan J and Temmingh, Henk and Uhlmann, Anne and {De Zubicaray}, Greig I and McMahon, Katie L and Wright, Margie and Cobia, Derin and Csernansky, John G and Thompson, Paul M and Turner, Jessica A and Wang, Lei},
doi = {10.1002/hbm.25625},
file = {:Users/jacquelinebracher/Zotero/storage/FWEG78QX/Gutman et al. - 2022 - A meta‐anal.pdf:pdf},
issn = {1065-9471, 1097-0193},
journal = {Human Brain Mapping},
month = {jan},
number = {1},
pages = {352--372},
shorttitle = {A {\textless}span style="font-variant},
title = {{A {\textless}span style="font-variant:small-caps;"{\textgreater}meta‐analysis{\textless}/span{\textgreater}of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the {\textless}span style="font-variant:small-caps;"{\textgreater}{\{}ENIGMA{\}} }},
url = {https://onlinelibrary.wiley.com/doi/10.1002/hbm.25625},
volume = {43},
year = {2022}
}

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