The single-port concept: combining optical glucose measurement with insulin infusion. Hajnsek, M., Nacht, B., Sax, S., List, E. J. W., Klimant, I., & Sinner, F. ACTA DIABETOLOGICA, 51(5):883-886, OCT, 2014. doi abstract bibtex The aim of this study was to develop a single-port system that combines glucose monitoring and insulin infusion. In a preclinical proof-of-concept trial, the performance of the glucose measurement at the site of insulin infusion was assessed. Glucose levels were clamped from 40 to 250 mg/dL by intravenous glucose infusion and subcutaneous insulin infusion via the glucose sensor. Sensor-glucose values correlated well with reference blood-glucose values, despite infusion at the site of glucose measurement. The average median ARE value was 21.6 +/- A 5.7 % for sensors used for insulin infusion, 18.1 +/- A 5.8 % for sensors used for NaCl infusion and 19.2 +/- A 7.9 % for sensors without infusion. These preclinical in vivo results demonstrate that single-port glucose monitoring is feasible at the site of insulin infusion.
@article{ ISI:000342427800021,
Author = {Hajnsek, Martin and Nacht, Barbara and Sax, Stefan and List, Emil J. W.
and Klimant, Ingo and Sinner, Frank},
Title = {{The single-port concept: combining optical glucose measurement with
insulin infusion}},
Journal = {{ACTA DIABETOLOGICA}},
Year = {{2014}},
Volume = {{51}},
Number = {{5}},
Pages = {{883-886}},
Month = {{OCT}},
Abstract = {{The aim of this study was to develop a single-port system that combines
glucose monitoring and insulin infusion. In a preclinical
proof-of-concept trial, the performance of the glucose measurement at
the site of insulin infusion was assessed. Glucose levels were clamped
from 40 to 250 mg/dL by intravenous glucose infusion and subcutaneous
insulin infusion via the glucose sensor. Sensor-glucose values
correlated well with reference blood-glucose values, despite infusion at
the site of glucose measurement. The average median ARE value was 21.6
+/- A 5.7 \% for sensors used for insulin infusion, 18.1 +/- A 5.8 \%
for sensors used for NaCl infusion and 19.2 +/- A 7.9 \% for sensors
without infusion. These preclinical in vivo results demonstrate that
single-port glucose monitoring is feasible at the site of insulin
infusion.}},
DOI = {{10.1007/s00592-014-0578-y}},
ISSN = {{0940-5429}},
EISSN = {{1432-5233}},
ResearcherID-Numbers = {{List-Kratochvil, Emil J.W. J.W./M-5312-2013}},
ORCID-Numbers = {{List-Kratochvil, Emil J.W. J.W./0000-0001-9206-800X}},
Unique-ID = {{ISI:000342427800021}},
}
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