Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles

Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles. Halassa, M. M, Siegle, J. H, Ritt, J. T, Ting, J. T, Feng, G., & Moore, C. I Nature Neuroscience, 14(9):1118–1120, September, 2011.

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The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.

@article{halassa_selective_2011,
	title = {Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles},
	volume = {14},
	issn = {1097-6256, 1546-1726},
	url = {http://www.nature.com/articles/nn.2880},
	doi = {10.1038/nn.2880},
	abstract = {The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.},
	language = {en},
	number = {9},
	urldate = {2020-03-12},
	journal = {Nature Neuroscience},
	author = {Halassa, Michael M and Siegle, Joshua H and Ritt, Jason T and Ting, Jonathan T and Feng, Guoping and Moore, Christopher I},
	month = sep,
	year = {2011},
	pages = {1118--1120},
	file = {Accepted Version:/Users/jjallen/Zotero/storage/XVWQJ3W4/Halassa et al. - 2011 - Selective optical drive of thalamic reticular nucl.pdf:application/pdf}
}

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