@article{
 title = {Association between loss of heterozygosity of BRCA1 and BRCA2 and morphological attributes of sporadic breast cancer.},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {BRCA2 Protein,Breast Neoplasms,Breast Neoplasms: genetics,Breast Neoplasms: pathology,Carcinoma in Situ,Carcinoma in Situ: genetics,Carcinoma in Situ: pathology,Carcinoma, Ductal, Breast,Carcinoma, Ductal, Breast: genetics,Carcinoma, Ductal, Breast: pathology,Cell Nucleus,Cell Nucleus: pathology,Female,Genes, BRCA1,Genes, Tumor Suppressor,Germ-Line Mutation,Humans,Inflammation,Loss of Heterozygosity,Lymphocytes,Lymphocytes: pathology,Microsatellite Repeats,Mitosis,Neoplasm Proteins,Neoplasm Proteins: genetics,PTEN Phosphohydrolase,Phosphoric Monoester Hydrolases,Phosphoric Monoester Hydrolases: genetics,Receptors, Estrogen,Receptors, Estrogen: analysis,Receptors, Progesterone,Receptors, Progesterone: analysis,Transcription Factors,Transcription Factors: genetics,Tumor Suppressor Proteins},
 pages = {204-8},
 volume = {88},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11004669},
 month = {10},
 day = {15},
 id = {bf83330f-05a8-3c77-b603-a050db464ac6},
 created = {2017-06-19T13:41:37.312Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:41:37.481Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer a lifetime risk of malignancy. Distinctive morphological features have been attributed to these familial tumours; however, in sporadic breast cancer, the inter-relationship between loss of heterozygosity (LOH) of these loci and tumour morphology remains to be fully elucidated. We studied a series of 120 sporadic breast carcinomas using microsatellite markers to identify LOH of BRCA1, BRCA2, p53 and PTEN. The associations between loss at each of the loci were examined and related to tumour morphology. LOH of the 4 loci did not occur independently; there were highly significant associations between LOH of BRCA1 and both BRCA2 (p < 0.001) and p53 (p < 0.001). LOH at all 4 loci was significantly associated with a high degree of nuclear pleomorphism. Tumours with LOH of BRCA1 also had high mitotic indices, few tubules and a paucity of DCIS, all of which are morphological features similar to those described for familial cases. Following Bonferroni's correction for multiple tests, we found that the tumours with LOH of BRCA1 were still significantly associated with a high mitotic index (p = 0.0006) and a high degree of nuclear pleomorphism (p = 0.001).},
 bibtype = {article},
 author = {Hanby, a M and Kelsell, D P and Potts, H W and Gillett, C E and Bishop, D T and Spurr, N K and Barnes, D M},
 journal = {International journal of cancer. Journal international du cancer},
 number = {2}
}

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Distinctive morphological features have been attributed to these familial tumours; however, in sporadic breast cancer, the inter-relationship between loss of heterozygosity (LOH) of these loci and tumour morphology remains to be fully elucidated. We studied a series of 120 sporadic breast carcinomas using microsatellite markers to identify LOH of BRCA1, BRCA2, p53 and PTEN. The associations between loss at each of the loci were examined and related to tumour morphology. LOH of the 4 loci did not occur independently; there were highly significant associations between LOH of BRCA1 and both BRCA2 (p < 0.001) and p53 (p < 0.001). LOH at all 4 loci was significantly associated with a high degree of nuclear pleomorphism. Tumours with LOH of BRCA1 also had high mitotic indices, few tubules and a paucity of DCIS, all of which are morphological features similar to those described for familial cases. Following Bonferroni's correction for multiple tests, we found that the tumours with LOH of BRCA1 were still significantly associated with a high mitotic index (p = 0.0006) and a high degree of nuclear pleomorphism (p = 0.001).","bibtype":"article","author":"Hanby, a M and Kelsell, D P and Potts, H W and Gillett, C E and Bishop, D T and Spurr, N K and Barnes, D M","journal":"International journal of cancer. Journal international du cancer","number":"2","bibtex":"@article{\n title = {Association between loss of heterozygosity of BRCA1 and BRCA2 and morphological attributes of sporadic breast cancer.},\n type = {article},\n year = {2000},\n identifiers = {[object Object]},\n keywords = {BRCA2 Protein,Breast Neoplasms,Breast Neoplasms: genetics,Breast Neoplasms: pathology,Carcinoma in Situ,Carcinoma in Situ: genetics,Carcinoma in Situ: pathology,Carcinoma, Ductal, Breast,Carcinoma, Ductal, Breast: genetics,Carcinoma, Ductal, Breast: pathology,Cell Nucleus,Cell Nucleus: pathology,Female,Genes, BRCA1,Genes, Tumor Suppressor,Germ-Line Mutation,Humans,Inflammation,Loss of Heterozygosity,Lymphocytes,Lymphocytes: pathology,Microsatellite Repeats,Mitosis,Neoplasm Proteins,Neoplasm Proteins: genetics,PTEN Phosphohydrolase,Phosphoric Monoester Hydrolases,Phosphoric Monoester Hydrolases: genetics,Receptors, Estrogen,Receptors, Estrogen: analysis,Receptors, Progesterone,Receptors, Progesterone: analysis,Transcription Factors,Transcription Factors: genetics,Tumor Suppressor Proteins},\n pages = {204-8},\n volume = {88},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/11004669},\n month = {10},\n day = {15},\n id = {bf83330f-05a8-3c77-b603-a050db464ac6},\n created = {2017-06-19T13:41:37.312Z},\n file_attached = {true},\n profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},\n group_id = {b2078731-0913-33b9-8902-a53629a24e83},\n last_modified = {2017-06-19T13:41:37.481Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n abstract = {Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer a lifetime risk of malignancy. Distinctive morphological features have been attributed to these familial tumours; however, in sporadic breast cancer, the inter-relationship between loss of heterozygosity (LOH) of these loci and tumour morphology remains to be fully elucidated. We studied a series of 120 sporadic breast carcinomas using microsatellite markers to identify LOH of BRCA1, BRCA2, p53 and PTEN. The associations between loss at each of the loci were examined and related to tumour morphology. LOH of the 4 loci did not occur independently; there were highly significant associations between LOH of BRCA1 and both BRCA2 (p < 0.001) and p53 (p < 0.001). LOH at all 4 loci was significantly associated with a high degree of nuclear pleomorphism. Tumours with LOH of BRCA1 also had high mitotic indices, few tubules and a paucity of DCIS, all of which are morphological features similar to those described for familial cases. Following Bonferroni's correction for multiple tests, we found that the tumours with LOH of BRCA1 were still significantly associated with a high mitotic index (p = 0.0006) and a high degree of nuclear pleomorphism (p = 0.001).},\n bibtype = {article},\n author = {Hanby, a M and Kelsell, D P and Potts, H W and Gillett, C E and Bishop, D T and Spurr, N K and Barnes, D M},\n journal = {International journal of cancer. 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