@article{hanifin_evolutionary_2014,
	title = {Evolutionary history of a complex adaptation: {Tetrodotoxin} resistance in salamanders},
	copyright = {This article is protected by copyright. All rights reserved},
	issn = {1558-5646},
	shorttitle = {Evolutionary history of a complex adaptation},
	url = {http://onlinelibrary.wiley.com/doi/10.1111/evo.12552/abstract},
	doi = {10.1111/evo.12552},
	abstract = {Understanding the processes that generate novel adaptive phenotypes is central to evolutionary biology. We used comparative analyses to reveal the history of tetrodotoxin (TTX) resistance in TTX-bearing salamanders. Resistance to TTX is a critical component of the ability to use TTX defensively but the origin of the TTX-bearing phenotype is unclear. Skeletal muscle of TTX-bearing salamanders (modern newts, family: Salamandridae) is unaffected by TTX at doses far in excess of those that block action potentials in muscle and nerve of other vertebrates. Skeletal muscle of non TTX-bearing salamandrids is also resistant to TTX but at lower levels. Skeletal muscle TTX-resistance in the Salamandridae results from the expression of TTX-resistant variants of the voltage-gated sodium channel NaV 1.4 (SCN4a). We identified four substitutions in the coding region of salSCN4a that are likely responsible for the TTX-resistance measured in TTX-bearing salamanders and variation at one of these sites likely explains variation in TTX-resistance among other lineages. Our results suggest that exaptation has played a role in the evolution of the TTX-bearing phenotype and provide empirical evidence that complex physiological adaptations can arise through the accumulation of beneficial mutations in the coding region of conserved proteins. This article is protected by copyright. All rights reserved.},
	language = {en},
	urldate = {2014-10-28TZ},
	journal = {Evolution},
	author = {Hanifin, Charles T and Gilly, William F},
	month = oct,
	year = {2014},
	keywords = {Adaptation, Caudata, Salamandridae, evolutionary genomics, molecular evolution},
	pages = {n/a--n/a}
}

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We used comparative analyses to reveal the history of tetrodotoxin (TTX) resistance in TTX-bearing salamanders. Resistance to TTX is a critical component of the ability to use TTX defensively but the origin of the TTX-bearing phenotype is unclear. Skeletal muscle of TTX-bearing salamanders (modern newts, family: Salamandridae) is unaffected by TTX at doses far in excess of those that block action potentials in muscle and nerve of other vertebrates. Skeletal muscle of non TTX-bearing salamandrids is also resistant to TTX but at lower levels. Skeletal muscle TTX-resistance in the Salamandridae results from the expression of TTX-resistant variants of the voltage-gated sodium channel NaV 1.4 (SCN4a). We identified four substitutions in the coding region of salSCN4a that are likely responsible for the TTX-resistance measured in TTX-bearing salamanders and variation at one of these sites likely explains variation in TTX-resistance among other lineages. Our results suggest that exaptation has played a role in the evolution of the TTX-bearing phenotype and provide empirical evidence that complex physiological adaptations can arise through the accumulation of beneficial mutations in the coding region of conserved proteins. This article is protected by copyright. All rights reserved.","language":"en","urldate":"2014-10-28TZ","journal":"Evolution","author":[{"propositions":[],"lastnames":["Hanifin"],"firstnames":["Charles","T"],"suffixes":[]},{"propositions":[],"lastnames":["Gilly"],"firstnames":["William","F"],"suffixes":[]}],"month":"October","year":"2014","keywords":"Adaptation, Caudata, Salamandridae, evolutionary genomics, molecular evolution","pages":"n/a–n/a","bibtex":"@article{hanifin_evolutionary_2014,\n\ttitle = {Evolutionary history of a complex adaptation: {Tetrodotoxin} resistance in salamanders},\n\tcopyright = {This article is protected by copyright. All rights reserved},\n\tissn = {1558-5646},\n\tshorttitle = {Evolutionary history of a complex adaptation},\n\turl = {http://onlinelibrary.wiley.com/doi/10.1111/evo.12552/abstract},\n\tdoi = {10.1111/evo.12552},\n\tabstract = {Understanding the processes that generate novel adaptive phenotypes is central to evolutionary biology. We used comparative analyses to reveal the history of tetrodotoxin (TTX) resistance in TTX-bearing salamanders. Resistance to TTX is a critical component of the ability to use TTX defensively but the origin of the TTX-bearing phenotype is unclear. Skeletal muscle of TTX-bearing salamanders (modern newts, family: Salamandridae) is unaffected by TTX at doses far in excess of those that block action potentials in muscle and nerve of other vertebrates. Skeletal muscle of non TTX-bearing salamandrids is also resistant to TTX but at lower levels. Skeletal muscle TTX-resistance in the Salamandridae results from the expression of TTX-resistant variants of the voltage-gated sodium channel NaV 1.4 (SCN4a). We identified four substitutions in the coding region of salSCN4a that are likely responsible for the TTX-resistance measured in TTX-bearing salamanders and variation at one of these sites likely explains variation in TTX-resistance among other lineages. Our results suggest that exaptation has played a role in the evolution of the TTX-bearing phenotype and provide empirical evidence that complex physiological adaptations can arise through the accumulation of beneficial mutations in the coding region of conserved proteins. This article is protected by copyright. All rights reserved.},\n\tlanguage = {en},\n\turldate = {2014-10-28TZ},\n\tjournal = {Evolution},\n\tauthor = {Hanifin, Charles T and Gilly, William F},\n\tmonth = oct,\n\tyear = {2014},\n\tkeywords = {Adaptation, Caudata, Salamandridae, evolutionary genomics, molecular evolution},\n\tpages = {n/a--n/a}\n}\n\n","author_short":["Hanifin, C. T","Gilly, W. 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