@article{
 title = {Multimodality functional imaging of spontaneous canine tumors using 64Cu-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Animals,Contrast Media,Copper Radioisotopes/diagnostic use,Dog Diseases/radionuclide imaging,Dogs,Fluorodeoxyglucose F18/diagnostic use,Multimodal Imaging/methods,Neoplasms/radionuclide imaging/veterinary,Organometallic Compounds/diagnostic use,Perfusion Imaging/methods,Positron-Emission Tomography,Radiographic Image Enhancement/methods,Radiopharmaceuticals/diagnostic use,Thiosemicarbazones/diagnostic use,Tomography, X-Ray Computed},
 pages = {424-428},
 volume = {102},
 month = {3},
 publisher = {Elsevier Ireland Ltd},
 city = {Department of Small Animal Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark. aeha@life.ku.dk},
 id = {5132b8ae-84b5-3ed3-8b61-e68b89fbf4a2},
 created = {2016-09-06T13:34:40.000Z},
 file_attached = {false},
 profile_id = {cacab941-be62-3845-982b-a7700857a11d},
 last_modified = {2016-09-07T14:54:40.000Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {LR: 20131121; CI: Copyright (c) 2011; JID: 8407192; 0 (Contrast Media); 0 (Copper Radioisotopes); 0 (Organometallic Compounds); 0 (Radiopharmaceuticals); 0 (Thiosemicarbazones); 0 (copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 2011/07/29 [received]; 2011/10/13 [revised]; 2011/10/24 [accepted]; 2011/11/24 [aheadofprint]; ppublish},
 abstract = {PURPOSE: To compare the distribution and uptake of the hypoxia tracer (64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazone) ((64)Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition (64)Cu-ATSM distribution over time was evaluated. METHODS AND MATERIALS: Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1h pi.) and (64)Cu-ATSM (3 and 24h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and (64)Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, (64)Cu-ATSM and CT perfusion parameters correlated. RESULTS: (64)Cu-ATSM distribution on scans performed 24h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of (64)Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to (64)Cu-ATSM yielded more varying results. CONCLUSIONS: (64)Cu-ATSM uptake was positively correlated to FDG. (64)Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for (64)Cu-ATSM imaging may be needed. Although a moderate to strong correlation between (64)Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.},
 bibtype = {article},
 author = {Hansen, A E and Kristensen, A T and Law, I and McEvoy, F J and Kjaer, A and Engelholm, S A},
 journal = {Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
 number = {3}
}

{"_id":"EF7ScQcvgSAt2DpAy","bibbaseid":"hansen-kristensen-law-mcevoy-kjaer-engelholm-multimodalityfunctionalimagingofspontaneouscaninetumorsusing64cuatsmand18fdgpetctanddynamiccontrastenhancedperfusionct-2012","downloads":0,"creationDate":"2016-09-07T14:55:09.966Z","title":"Multimodality functional imaging of spontaneous canine tumors using 64Cu-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT","author_short":["Hansen, A., E.","Kristensen, A., T.","Law, I.","McEvoy, F., J.","Kjaer, A.","Engelholm, S., A."],"year":2012,"bibtype":"article","biburl":null,"bibdata":{"title":"Multimodality functional imaging of spontaneous canine tumors using 64Cu-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT","type":"article","year":"2012","identifiers":"[object Object]","keywords":"Animals,Contrast Media,Copper Radioisotopes/diagnostic use,Dog Diseases/radionuclide imaging,Dogs,Fluorodeoxyglucose F18/diagnostic use,Multimodal Imaging/methods,Neoplasms/radionuclide imaging/veterinary,Organometallic Compounds/diagnostic use,Perfusion Imaging/methods,Positron-Emission Tomography,Radiographic Image Enhancement/methods,Radiopharmaceuticals/diagnostic use,Thiosemicarbazones/diagnostic use,Tomography, X-Ray Computed","pages":"424-428","volume":"102","month":"3","publisher":"Elsevier Ireland Ltd","city":"Department of Small Animal Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark. aeha@life.ku.dk","id":"5132b8ae-84b5-3ed3-8b61-e68b89fbf4a2","created":"2016-09-06T13:34:40.000Z","file_attached":false,"profile_id":"cacab941-be62-3845-982b-a7700857a11d","last_modified":"2016-09-07T14:54:40.000Z","read":false,"starred":false,"authored":"true","confirmed":"true","hidden":false,"source_type":"JOUR","notes":"LR: 20131121; CI: Copyright (c) 2011; JID: 8407192; 0 (Contrast Media); 0 (Copper Radioisotopes); 0 (Organometallic Compounds); 0 (Radiopharmaceuticals); 0 (Thiosemicarbazones); 0 (copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 2011/07/29 [received]; 2011/10/13 [revised]; 2011/10/24 [accepted]; 2011/11/24 [aheadofprint]; ppublish","abstract":"PURPOSE: To compare the distribution and uptake of the hypoxia tracer (64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazone) ((64)Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition (64)Cu-ATSM distribution over time was evaluated. METHODS AND MATERIALS: Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1h pi.) and (64)Cu-ATSM (3 and 24h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and (64)Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, (64)Cu-ATSM and CT perfusion parameters correlated. RESULTS: (64)Cu-ATSM distribution on scans performed 24h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of (64)Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to (64)Cu-ATSM yielded more varying results. CONCLUSIONS: (64)Cu-ATSM uptake was positively correlated to FDG. (64)Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for (64)Cu-ATSM imaging may be needed. Although a moderate to strong correlation between (64)Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.","bibtype":"article","author":"Hansen, A E and Kristensen, A T and Law, I and McEvoy, F J and Kjaer, A and Engelholm, S A","journal":"Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology","number":"3","bibtex":"@article{\n title = {Multimodality functional imaging of spontaneous canine tumors using 64Cu-ATSM and 18FDG PET/CT and dynamic contrast enhanced perfusion CT},\n type = {article},\n year = {2012},\n identifiers = {[object Object]},\n keywords = {Animals,Contrast Media,Copper Radioisotopes/diagnostic use,Dog Diseases/radionuclide imaging,Dogs,Fluorodeoxyglucose F18/diagnostic use,Multimodal Imaging/methods,Neoplasms/radionuclide imaging/veterinary,Organometallic Compounds/diagnostic use,Perfusion Imaging/methods,Positron-Emission Tomography,Radiographic Image Enhancement/methods,Radiopharmaceuticals/diagnostic use,Thiosemicarbazones/diagnostic use,Tomography, X-Ray Computed},\n pages = {424-428},\n volume = {102},\n month = {3},\n publisher = {Elsevier Ireland Ltd},\n city = {Department of Small Animal Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark. aeha@life.ku.dk},\n id = {5132b8ae-84b5-3ed3-8b61-e68b89fbf4a2},\n created = {2016-09-06T13:34:40.000Z},\n file_attached = {false},\n profile_id = {cacab941-be62-3845-982b-a7700857a11d},\n last_modified = {2016-09-07T14:54:40.000Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n source_type = {JOUR},\n notes = {LR: 20131121; CI: Copyright (c) 2011; JID: 8407192; 0 (Contrast Media); 0 (Copper Radioisotopes); 0 (Organometallic Compounds); 0 (Radiopharmaceuticals); 0 (Thiosemicarbazones); 0 (copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 2011/07/29 [received]; 2011/10/13 [revised]; 2011/10/24 [accepted]; 2011/11/24 [aheadofprint]; ppublish},\n abstract = {PURPOSE: To compare the distribution and uptake of the hypoxia tracer (64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazone) ((64)Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition (64)Cu-ATSM distribution over time was evaluated. METHODS AND MATERIALS: Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1h pi.) and (64)Cu-ATSM (3 and 24h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and (64)Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, (64)Cu-ATSM and CT perfusion parameters correlated. RESULTS: (64)Cu-ATSM distribution on scans performed 24h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of (64)Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to (64)Cu-ATSM yielded more varying results. CONCLUSIONS: (64)Cu-ATSM uptake was positively correlated to FDG. (64)Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for (64)Cu-ATSM imaging may be needed. Although a moderate to strong correlation between (64)Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.},\n bibtype = {article},\n author = {Hansen, A E and Kristensen, A T and Law, I and McEvoy, F J and Kjaer, A and Engelholm, S A},\n journal = {Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},\n number = {3}\n}","author_short":["Hansen, A., E.","Kristensen, A., T.","Law, I.","McEvoy, F., J.","Kjaer, A.","Engelholm, S., A."],"bibbaseid":"hansen-kristensen-law-mcevoy-kjaer-engelholm-multimodalityfunctionalimagingofspontaneouscaninetumorsusing64cuatsmand18fdgpetctanddynamiccontrastenhancedperfusionct-2012","role":"author","urls":{},"keyword":["Animals","Contrast Media","Copper Radioisotopes/diagnostic use","Dog Diseases/radionuclide imaging","Dogs","Fluorodeoxyglucose F18/diagnostic use","Multimodal Imaging/methods","Neoplasms/radionuclide imaging/veterinary","Organometallic Compounds/diagnostic use","Perfusion Imaging/methods","Positron-Emission Tomography","Radiographic Image Enhancement/methods","Radiopharmaceuticals/diagnostic use","Thiosemicarbazones/diagnostic use","Tomography","X-Ray Computed"],"downloads":0,"html":""},"search_terms":["multimodality","functional","imaging","spontaneous","canine","tumors","using","64cu","atsm","18fdg","pet","dynamic","contrast","enhanced","perfusion","hansen","kristensen","law","mcevoy","kjaer","engelholm"],"keywords":["animals","contrast media","copper radioisotopes/diagnostic use","dog diseases/radionuclide imaging","dogs","fluorodeoxyglucose f18/diagnostic use","multimodal imaging/methods","neoplasms/radionuclide imaging/veterinary","organometallic compounds/diagnostic use","perfusion imaging/methods","positron-emission tomography","radiographic image enhancement/methods","radiopharmaceuticals/diagnostic use","thiosemicarbazones/diagnostic use","tomography","x-ray computed"],"authorIDs":[]}