Iron and metal regulation in bacteria. Hantke, K Current Opinion in Microbiology, 4(2):172--177, April, 2001.
Iron and metal regulation in bacteria [link]Paper  abstract   bibtex   
In Escherichia coli, the iron regulator Fur is regulated by two oxidative-stress response regulators. The generation of dangerous radicals by oxygen and iron is the basis for this dual regulation, which is also found in eukaryotes. The binding of iron-regulated transcripts to apo-aconitase and results of mRNA half-life studies indicate that there is post-transcriptional iron regulation in bacteria, as in eukaryotes. Fur contains two metal-binding sites, one for Zn2+ and one for Fe2+. Zinc uptake systems are regulated by members of the Fur protein family, and zinc is a cofactor. DtxR and related proteins constitute another family of iron regulators, first found in Gram-positive organisms with a high GC content. In organisms with Fur-dependent iron regulation, members of the DtxR family regulate manganese transport.
@article{hantke_iron_2001,
	title = {Iron and metal regulation in bacteria},
	volume = {4},
	issn = {1369-5274},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11282473},
	abstract = {In Escherichia coli, the iron regulator Fur is regulated by two oxidative-stress response regulators. The generation of dangerous radicals by oxygen and iron is the basis for this dual regulation, which is also found in eukaryotes. The binding of iron-regulated transcripts to apo-aconitase and results of mRNA half-life studies indicate that there is post-transcriptional iron regulation in bacteria, as in eukaryotes. Fur contains two metal-binding sites, one for Zn2+ and one for Fe2+. Zinc uptake systems are regulated by members of the Fur protein family, and zinc is a cofactor. DtxR and related proteins constitute another family of iron regulators, first found in Gram-positive organisms with a high GC content. In organisms with Fur-dependent iron regulation, members of the DtxR family regulate manganese transport.},
	number = {2},
	urldate = {2009-09-03TZ},
	journal = {Current Opinion in Microbiology},
	author = {Hantke, K},
	month = apr,
	year = {2001},
	pmid = {11282473},
	keywords = {Aconitate Hydratase, Bacteria, Bacterial Proteins, DNA-Binding Proteins, Escherichia coli, Gene Expression Regulation, Bacterial, Iron, Manganese, RNA Processing, Post-Transcriptional, Repressor Proteins, Siderophores, Transcription, Genetic, Zinc},
	pages = {172--177}
}
Downloads: 0