Iron and metal regulation in bacteria. Hantke, K Current Opinion in Microbiology, 4(2):172--177, April, 2001. ![Iron and metal regulation in bacteria [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex In Escherichia coli, the iron regulator Fur is regulated by two oxidative-stress response regulators. The generation of dangerous radicals by oxygen and iron is the basis for this dual regulation, which is also found in eukaryotes. The binding of iron-regulated transcripts to apo-aconitase and results of mRNA half-life studies indicate that there is post-transcriptional iron regulation in bacteria, as in eukaryotes. Fur contains two metal-binding sites, one for Zn2+ and one for Fe2+. Zinc uptake systems are regulated by members of the Fur protein family, and zinc is a cofactor. DtxR and related proteins constitute another family of iron regulators, first found in Gram-positive organisms with a high GC content. In organisms with Fur-dependent iron regulation, members of the DtxR family regulate manganese transport.
@article{hantke_iron_2001,
title = {Iron and metal regulation in bacteria},
volume = {4},
issn = {1369-5274},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11282473},
abstract = {In Escherichia coli, the iron regulator Fur is regulated by two oxidative-stress response regulators. The generation of dangerous radicals by oxygen and iron is the basis for this dual regulation, which is also found in eukaryotes. The binding of iron-regulated transcripts to apo-aconitase and results of mRNA half-life studies indicate that there is post-transcriptional iron regulation in bacteria, as in eukaryotes. Fur contains two metal-binding sites, one for Zn2+ and one for Fe2+. Zinc uptake systems are regulated by members of the Fur protein family, and zinc is a cofactor. DtxR and related proteins constitute another family of iron regulators, first found in Gram-positive organisms with a high GC content. In organisms with Fur-dependent iron regulation, members of the DtxR family regulate manganese transport.},
number = {2},
urldate = {2009-09-03TZ},
journal = {Current Opinion in Microbiology},
author = {Hantke, K},
month = apr,
year = {2001},
pmid = {11282473},
keywords = {Aconitate Hydratase, Bacteria, Bacterial Proteins, DNA-Binding Proteins, Escherichia coli, Gene Expression Regulation, Bacterial, Iron, Manganese, RNA Processing, Post-Transcriptional, Repressor Proteins, Siderophores, Transcription, Genetic, Zinc},
pages = {172--177}
}
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