Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis. Harding, S., Provot, F., Beuscart, J., Cook, M., Bradwell, A. R, Stringer, S., White, D., Cockwell, P., & Hutchison, C. A Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association, 26(4):1438, April, 2011. ![Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.
@article{harding_aggregated_2011,
title = {Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis},
volume = {26},
issn = {1460-2385},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21406545},
doi = {10.1093/ndt/gfr019},
abstract = {Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.},
number = {4},
urldate = {2011-10-06},
journal = {Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association},
author = {Harding, Stephen and Provot, Francois and Beuscart, Jean-Baptise and Cook, Mark and Bradwell, Arthur R and Stringer, Stephanie and White, Darren and Cockwell, Paul and Hutchison, Colin A},
month = apr,
year = {2011},
pmid = {21406545},
keywords = {Chromatography, Gel, Female, Humans, Immunoglobulin Light Chains, Kidney Failure, Chronic, Male, Middle Aged, Multiple Myeloma, Renal Dialysis},
pages = {1438},
}
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