@Article{Hart2019,
  author       = {Martin Hart and Barbara Walch-Rückheim and Kim S Friedmann and Stefanie Rheinheimer and Tanja Tänzer and Birgit Glombitza and Martina Sester and Hans-Peter Lenhof and Markus Hoth and Eva C Schwarz and Andreas Keller and Eckart Meese},
  title        = {miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling},
  journal      = {Cell death & disease},
  publisher    = {Nature Publishing Group},
  year         = {2019},
  volume       = {10},
  issue        = {2},
  pages        = {46},
  issn         = {46},
  issn-linking = {46},
  month        = jan,
  abstract     = {NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB signalosome with miR-34a binding sites in 14 key members of the NF-κB signaling pathway. Functional analysis identified five target genes of miR-34a including PLCG1, CD3E, PIK3CB, TAB2, and NFΚBIA. Overexpression of miR-34a in CD4+ and CD8+ T cells led to a significant decrease of NFΚBIA as the most downstream cytoplasmic NF-κB member, a reduced cell surface abundance of TCRA and CD3E, and to a reduction of T cell killing capacity. Inhibition of miR-34a caused an increase of NFΚBIA, TCRA, and CD3E. Notably, activation of CD4+ and CD8+ T cells entrails a gradual increase of miR-34a. Our results lend further support to a model with miR-34a as a central NF-κB regulator in T cells.},
  doi          = {10.1038/s41419-018-1295-1},
  pii          = {10.1038/s41419-018-1295-1},
}

{"_id":"TsSebWMJpahWqn6TR","bibbaseid":"hart-walchrckheim-friedmann-rheinheimer-tnzer-glombitza-sester-lenhof-etal-mir34aanewplayerintheregulationoftcellfunctionbymodulationofnfbsignaling-2019","author_short":["Hart, M.","Walch-Rückheim, B.","Friedmann, K. S","Rheinheimer, S.","Tänzer, T.","Glombitza, B.","Sester, M.","Lenhof, H.","Hoth, M.","Schwarz, E. C","Keller, A.","Meese, E."],"bibdata":{"bibtype":"article","type":"article","author":[{"firstnames":["Martin"],"propositions":[],"lastnames":["Hart"],"suffixes":[]},{"firstnames":["Barbara"],"propositions":[],"lastnames":["Walch-Rückheim"],"suffixes":[]},{"firstnames":["Kim","S"],"propositions":[],"lastnames":["Friedmann"],"suffixes":[]},{"firstnames":["Stefanie"],"propositions":[],"lastnames":["Rheinheimer"],"suffixes":[]},{"firstnames":["Tanja"],"propositions":[],"lastnames":["Tänzer"],"suffixes":[]},{"firstnames":["Birgit"],"propositions":[],"lastnames":["Glombitza"],"suffixes":[]},{"firstnames":["Martina"],"propositions":[],"lastnames":["Sester"],"suffixes":[]},{"firstnames":["Hans-Peter"],"propositions":[],"lastnames":["Lenhof"],"suffixes":[]},{"firstnames":["Markus"],"propositions":[],"lastnames":["Hoth"],"suffixes":[]},{"firstnames":["Eva","C"],"propositions":[],"lastnames":["Schwarz"],"suffixes":[]},{"firstnames":["Andreas"],"propositions":[],"lastnames":["Keller"],"suffixes":[]},{"firstnames":["Eckart"],"propositions":[],"lastnames":["Meese"],"suffixes":[]}],"title":"miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling","journal":"Cell death & disease","publisher":"Nature Publishing Group","year":"2019","volume":"10","issue":"2","pages":"46","issn":"46","issn-linking":"46","month":"January","abstract":"NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB signalosome with miR-34a binding sites in 14 key members of the NF-κB signaling pathway. Functional analysis identified five target genes of miR-34a including PLCG1, CD3E, PIK3CB, TAB2, and NFΚBIA. Overexpression of miR-34a in CD4+ and CD8+ T cells led to a significant decrease of NFΚBIA as the most downstream cytoplasmic NF-κB member, a reduced cell surface abundance of TCRA and CD3E, and to a reduction of T cell killing capacity. Inhibition of miR-34a caused an increase of NFΚBIA, TCRA, and CD3E. Notably, activation of CD4+ and CD8+ T cells entrails a gradual increase of miR-34a. Our results lend further support to a model with miR-34a as a central NF-κB regulator in T cells.","doi":"10.1038/s41419-018-1295-1","pii":"10.1038/s41419-018-1295-1","bibtex":"@Article{Hart2019,\n author = {Martin Hart and Barbara Walch-Rückheim and Kim S Friedmann and Stefanie Rheinheimer and Tanja Tänzer and Birgit Glombitza and Martina Sester and Hans-Peter Lenhof and Markus Hoth and Eva C Schwarz and Andreas Keller and Eckart Meese},\n title = {miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling},\n journal = {Cell death & disease},\n publisher = {Nature Publishing Group},\n year = {2019},\n volume = {10},\n issue = {2},\n pages = {46},\n issn = {46},\n issn-linking = {46},\n month = jan,\n abstract = {NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB signalosome with miR-34a binding sites in 14 key members of the NF-κB signaling pathway. Functional analysis identified five target genes of miR-34a including PLCG1, CD3E, PIK3CB, TAB2, and NFΚBIA. Overexpression of miR-34a in CD4+ and CD8+ T cells led to a significant decrease of NFΚBIA as the most downstream cytoplasmic NF-κB member, a reduced cell surface abundance of TCRA and CD3E, and to a reduction of T cell killing capacity. Inhibition of miR-34a caused an increase of NFΚBIA, TCRA, and CD3E. Notably, activation of CD4+ and CD8+ T cells entrails a gradual increase of miR-34a. Our results lend further support to a model with miR-34a as a central NF-κB regulator in T cells.},\n doi = {10.1038/s41419-018-1295-1},\n pii = {10.1038/s41419-018-1295-1},\n}\n\n","author_short":["Hart, M.","Walch-Rückheim, B.","Friedmann, K. S","Rheinheimer, S.","Tänzer, T.","Glombitza, B.","Sester, M.","Lenhof, H.","Hoth, M.","Schwarz, E. C","Keller, A.","Meese, E."],"key":"Hart2019","id":"Hart2019","bibbaseid":"hart-walchrckheim-friedmann-rheinheimer-tnzer-glombitza-sester-lenhof-etal-mir34aanewplayerintheregulationoftcellfunctionbymodulationofnfbsignaling-2019","role":"author","urls":{},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://www.ccb.uni-saarland.de/wp-content/uploads/2024/11/references.bib_.txt","dataSources":["pTW7v7XACewjrTXET","BD2qbudjMvyXtTiz5","NmhXQcJvRc2QhnSZF","ipvH6pWABxuwdKDLx","Pny5E4E9kc7C8gG8g","SiGP46KPWizw6ihLJ","ZKiRa4gncFJ5e6f9M","CZZSbiMkXJgDMN2Ei","fMYw4bZ8PtmEvvgdF","XiRWyepSYzzAnCRoW","nqMohMYmMdCvacEct"],"keywords":[],"search_terms":["mir","34a","new","player","regulation","cell","function","modulation","signaling","hart","walch-rückheim","friedmann","rheinheimer","tänzer","glombitza","sester","lenhof","hoth","schwarz","keller","meese"],"title":"miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling","year":2019}