Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons. Harwell, C. C, Fuentealba, L. C, Gonzalez-Cerrillo, A., Parker, P. R L, Gertz, C. C, Mazzola, E., Garcia, M. T., Alvarez-Buylla, A., Cepko, C. L, & Kriegstein, A. R Neuron, 87(5):999–1007, August, 2015.
abstract   bibtex   
The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory interneurons, generated in dorsal and ventral progenitor zones of the embryonic telencephalon, respectively. Thus, inhibitory neurons migrate relatively long distances to reach their destination in the developing forebrain. The role of lineage in the organization and circuitry of interneurons is still not well understood. Utilizing a combination of genetics, retroviral fate mapping, and lineage-specific retroviral barcode labeling, we find that clonally related interneurons can be widely dispersed while unrelated interneurons can be closely clustered. These data suggest that migratory mechanisms related to the clustering of interneurons occur largely independent of their clonal origin.
@ARTICLE{Harwell2015-ng,
  title    = "Wide Dispersion and Diversity of Clonally Related Inhibitory
              Interneurons",
  author   = "Harwell, Corey C and Fuentealba, Luis C and Gonzalez-Cerrillo,
              Adrian and Parker, Phillip R L and Gertz, Caitlyn C and Mazzola,
              Emanuele and Garcia, Miguel Turrero and Alvarez-Buylla, Arturo
              and Cepko, Constance L and Kriegstein, Arnold R",
  abstract = "The mammalian neocortex is composed of two major neuronal cell
              types with distinct origins: excitatory pyramidal neurons and
              inhibitory interneurons, generated in dorsal and ventral
              progenitor zones of the embryonic telencephalon, respectively.
              Thus, inhibitory neurons migrate relatively long distances to
              reach their destination in the developing forebrain. The role of
              lineage in the organization and circuitry of interneurons is
              still not well understood. Utilizing a combination of genetics,
              retroviral fate mapping, and lineage-specific retroviral barcode
              labeling, we find that clonally related interneurons can be
              widely dispersed while unrelated interneurons can be closely
              clustered. These data suggest that migratory mechanisms related
              to the clustering of interneurons occur largely independent of
              their clonal origin.",
  journal  = "Neuron",
  volume   =  87,
  number   =  5,
  pages    = "999--1007",
  month    =  aug,
  year     =  2015,
  language = "en"
}

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