Hand joint space narrowing and osteophytes are associated with magnetic resonance imaging-defined knee cartilage thickness and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Haugen, I. K., Cotofana, S., Englund, M., Kvien, T. K., Dreher, D., Nevitt, M., Lane, N. E., & Eckstein, F. 39(1):161--166.
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OBJECTIVE: To evaluate whether features of radiographic hand osteoarthritis (OA) are associated with quantitative magnetic resonance imaging (MRI)-defined knee cartilage thickness, radiographic knee OA, and 1-year structural progression. METHODS: A total of 765 participants in Osteoarthritis Initiative (OAI; 455 women, mean age 62.5 yrs, SD 9.4) obtained hand radiographs (at baseline), knee radiographs (baseline and Year 1), and knee MRI (baseline and Year 1). Hand radiographs were scored for presence of osteophytes and joint space narrowing (JSN). Knee radiographs were scored according to the Kellgren-Lawrence (KL) scale. Cartilage thickness in the medial and lateral femorotibial compartments was measured quantitatively from coronal FLASHwe images. We examined the cross-sectional and longitudinal associations between features of hand OA (total osteophyte and JSN scores) and knee cartilage thickness, 1-year knee cartilage thinning (above smallest detectable change), presence of knee OA (KL grade \textgreater/= 3), and progression of knee OA (KL change \textgreater/= 1) by linear and logistic regression. Both hand OA features were included in a multivariate model (if p \textless/= 0.25) adjusted for age, sex, and body mass index (BMI). RESULTS: Hand JSN was associated with reduced knee cartilage thickness (ss = -0.02, 95% CI -0.03, -0.01) in the medial femorotibial compartment, while hand osteophytes were associated with the presence of radiographic knee OA (OR 1.10, 95% CI 1.03-1.18; multivariate models) with both hand OA features as independent variables adjusted for age, sex, and BMI). Radiographic features of hand OA were not associated with
@article{haugen_hand_2012,
	title = {Hand joint space narrowing and osteophytes are associated with magnetic resonance imaging-defined knee cartilage thickness and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative.},
	volume = {39},
	issn = {0315-162X 0315-162X},
	doi = {10.3899/jrheum.110603},
	abstract = {{OBJECTIVE}: To evaluate whether features of radiographic hand osteoarthritis ({OA})  are associated with quantitative magnetic resonance imaging ({MRI})-defined knee cartilage thickness, radiographic knee {OA}, and 1-year structural progression. {METHODS}: A total of 765 participants in Osteoarthritis Initiative ({OAI}; 455 women, mean age 62.5 yrs, {SD} 9.4) obtained hand radiographs (at baseline), knee radiographs (baseline and Year 1), and knee {MRI} (baseline and Year 1). Hand radiographs were scored for presence of osteophytes and joint space narrowing ({JSN}). Knee radiographs were scored according to the Kellgren-Lawrence ({KL}) scale. Cartilage thickness in the medial and lateral femorotibial compartments was measured quantitatively from coronal {FLASHwe} images. We examined the cross-sectional and longitudinal associations between features of hand {OA} (total  osteophyte and {JSN} scores) and knee cartilage thickness, 1-year knee cartilage thinning (above smallest detectable change), presence of knee {OA} ({KL} grade {\textgreater}/= 3), and progression of knee {OA} ({KL} change {\textgreater}/= 1) by linear and logistic regression. Both hand {OA} features were included in a multivariate model (if p {\textless}/= 0.25) adjusted for age, sex, and body mass index ({BMI}). {RESULTS}: Hand {JSN} was associated with reduced knee cartilage thickness (ss = -0.02, 95\% {CI} -0.03, -0.01) in the medial femorotibial compartment, while hand osteophytes were associated with the presence of radiographic knee {OA} ({OR} 1.10, 95\% {CI} 1.03-1.18;  multivariate models) with both hand {OA} features as independent variables adjusted for age, sex, and {BMI}). Radiographic features of hand {OA} were not associated with},
	pages = {161--166},
	number = {1},
	journaltitle = {The Journal of rheumatology},
	shortjournal = {J Rheumatol},
	author = {Haugen, Ida K. and Cotofana, Sebastian and Englund, Martin and Kvien, Tore K. and Dreher, Donatus and Nevitt, Michael and Lane, Nancy E. and Eckstein, Felix},
	date = {2012-01},
	pmid = {22045837},
	keywords = {*Cartilage, Articular/pathology/radiography, *Hand Joints/pathology/radiography, *Knee Joint/pathology/radiography, *Osteoarthritis, Knee/pathology/radiography, *Osteophyte/pathology/radiography, Aged, Biomarkers/metabolism, Cohort Studies, Disease Progression, Female, Humans, Magnetic Resonance Imaging/*methods, Male, Middle Aged, Prospective Studies}
}
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