Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study. Haugen, I. K., Englund, M., Aliabadi, P., Niu, J., Clancy, M., Kvien, T. K., & Felson, D. T. 70(9):1581--1586.
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OBJECTIVES: To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis (HOA) in the general population. METHODS: Framingham osteoarthritis (OA) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic HOA at joint level as Kellgren-Lawrence grade (KLG)\textgreater/=2, erosive HOA as KLG\textgreater/=2 plus erosion and symptomatic HOA as KLG\textgreater/=2 plus pain/aching/stiffness. Presence of HOA at individual level was defined as \textgreater/=1 affected joint. The prevalence was age-standardised (US 2000 Population 40-84 years). RESULTS: Mean (SD) baseline age was 58.9 (9.9) years (56.5% women). The age-standardised prevalence of HOA was only modestly higher in women (44.2%) than men (37.7%), whereas the age-standardised prevalence of erosive and symptomatic OA was much higher in women (9.9% vs 3.3%, and 15.9% vs 8.2%). The crude incidence of HOA over 9-year follow-up was similar in women (34.6%) and men (33.7%), whereas the majority of those women (96.4%) and men (91.4%) with HOA at baseline showed progression during follow-up. Incident metacarpophalangeal and wrist OA were rare, but occurred more frequently and from an earlier age in men than women. Development of erosive disease occurred mainly in those with non-erosive HOA at baseline (as opposed to those without HOA), and was more frequent in women (17.3%) than men (9.6%). CONCLUSIONS: The usual female predominance of prevalent and incident HOA was less clear for radiographic HOA than for symptomatic and erosive HOA. With an ageing population, the impact of HOA will further increase.
@article{haugen_prevalence_2011,
	title = {Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study.},
	volume = {70},
	issn = {1468-2060 0003-4967},
	doi = {10.1136/ard.2011.150078},
	abstract = {{OBJECTIVES}: To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis ({HOA}) in the general population. {METHODS}: Framingham osteoarthritis ({OA}) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic {HOA} at joint level as Kellgren-Lawrence grade ({KLG}){\textgreater}/=2, erosive {HOA} as {KLG}{\textgreater}/=2 plus erosion and symptomatic {HOA} as {KLG}{\textgreater}/=2 plus pain/aching/stiffness. Presence of {HOA} at individual level was defined as {\textgreater}/=1 affected joint. The prevalence was age-standardised ({US} 2000 Population 40-84 years). {RESULTS}: Mean ({SD}) baseline age was 58.9 (9.9) years (56.5\% women). The age-standardised prevalence of {HOA} was only modestly higher in women (44.2\%) than men (37.7\%), whereas the age-standardised prevalence of erosive and symptomatic {OA} was much higher in women (9.9\% vs 3.3\%, and 15.9\% vs 8.2\%). The crude incidence of {HOA} over 9-year follow-up was similar in women (34.6\%) and men (33.7\%), whereas the majority of those women (96.4\%) and men (91.4\%) with {HOA} at  baseline showed progression during follow-up. Incident metacarpophalangeal and wrist {OA} were rare, but occurred more frequently and from an earlier age in men than women. Development of erosive disease occurred mainly in those with non-erosive {HOA} at baseline (as opposed to those without {HOA}), and was more frequent in women (17.3\%) than men (9.6\%). {CONCLUSIONS}: The usual female predominance of prevalent and incident {HOA} was less clear for radiographic {HOA} than for symptomatic and erosive {HOA}. With an ageing population, the impact of {HOA} will further increase.},
	pages = {1581--1586},
	number = {9},
	journaltitle = {Annals of the rheumatic diseases},
	shortjournal = {Ann Rheum Dis},
	author = {Haugen, Ida K. and Englund, Martin and Aliabadi, Piran and Niu, Jingbo and Clancy, Margaret and Kvien, Tore K. and Felson, David T.},
	date = {2011-09},
	pmid = {21622766},
	pmcid = {PMC3867970},
	keywords = {*Hand Joints/pathology/radiography, Adult, Aged, Aged, 80 and over, Age Distribution, Disease Progression, Epidemiologic Methods, Female, Humans, Incidence, Male, Massachusetts/epidemiology, Middle Aged, Osteoarthritis/*epidemiology/pathology/radiography, Prevalence, Sex Distribution}
}
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