The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study. Haugen, I. K., Felson, D. T., Englund, M., Wang, K., Aliabadi, P., Guermazi, A., Roemer, F. W., & Neogi, T. 71(10):1698--1701.
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OBJECTIVE: To examine whether erosive hand osteoarthritis (OA) is associated with knee subchondral bone attrition (SBA) and systemic bone mineral density (BMD). METHODS: Associations of MRI-defined knee SBA with radiographic erosive hand OA were evaluated in 1253 Framingham participants using logistic regression with generalised estimating equations. We also examined the association between the number of erosive OA finger joints and SBA adjusted for the number of non-erosive OA finger joints. Associations between erosive hand OA and femoral neck BMD were explored in 2236 participants with linear regression. Analyses were adjusted for age, sex and body mass index. RESULTS: Participants with erosive hand OA had increased odds of knee SBA (OR=1.60, 95% CI 1.07 to 2.38). The relation between the number of erosive OA finger joints and SBA became non-significant when adjusted for the number of non-erosive OA joints as a proxy for the burden of disease. There was a non-significant trend towards higher BMD in erosive hand OA compared with participants without hand OA. CONCLUSIONS: Erosive hand OA was associated with knee SBA, but the relation might be best explained by a heightened burden of disease. No significant relation of erosive hand OA with BMD was found.
@article{haugen_association_2012,
	title = {The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study.},
	volume = {71},
	issn = {1468-2060 0003-4967},
	doi = {10.1136/annrheumdis-2012-201659},
	abstract = {{OBJECTIVE}: To examine whether erosive hand osteoarthritis ({OA}) is associated with knee subchondral bone attrition ({SBA}) and systemic bone mineral density ({BMD}). {METHODS}: Associations of {MRI}-defined knee {SBA} with radiographic erosive hand {OA} were evaluated in 1253 Framingham participants using logistic regression with generalised estimating equations. We also examined the association between the number of erosive {OA} finger joints and {SBA} adjusted for the number of non-erosive {OA} finger joints. Associations between erosive hand {OA} and femoral neck {BMD} were  explored in 2236 participants with linear regression. Analyses were adjusted for  age, sex and body mass index. {RESULTS}: Participants with erosive hand {OA} had increased odds of knee {SBA} ({OR}=1.60, 95\% {CI} 1.07 to 2.38). The relation between the number of erosive {OA} finger joints and {SBA} became non-significant when adjusted for the number of non-erosive {OA} joints as a proxy for the burden of disease. There was a non-significant trend towards higher {BMD} in erosive hand {OA}  compared with participants without hand {OA}. {CONCLUSIONS}: Erosive hand {OA} was associated with knee {SBA}, but the relation might be best explained by a heightened burden of disease. No significant relation of erosive hand {OA} with {BMD} was found.},
	pages = {1698--1701},
	number = {10},
	journaltitle = {Annals of the rheumatic diseases},
	shortjournal = {Ann Rheum Dis},
	author = {Haugen, Ida Kristin and Felson, David T. and Englund, Martin and Wang, Ke and Aliabadi, Piran and Guermazi, Ali and Roemer, Frank W. and Neogi, Tuhina},
	date = {2012-10},
	pmid = {22730369},
	pmcid = {PMC3653622},
	keywords = {Bone Density, Bone Diseases/complications/*radiography, Cohort Studies, Female, Femur Neck/*radiography, Finger Joint/*radiography, Hand/radiography, Humans, Knee/radiography, Male, Middle Aged, Osteoarthritis/complications/*radiography}
}
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