The associations between finger length pattern, osteoarthritis, and knee injury: data from the Framingham community cohort. Haugen, I. K., Niu, J., Aliabadi, P., Felson, D. T., & Englund, M. 63(8):2284--2288. doi abstract bibtex OBJECTIVE: To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis (OA), previous knee injury, and meniscal lesions in the general population. METHODS: We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging (MRI) were performed on subjects. Women and men were divided into tertiles according to their 2D:4D phalangeal and metacarpal ratios. We assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for radiographic knee OA, severe symptomatic knee OA, radiographic hand OA, previous knee injury, and MRI-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand OA may affect the 2D:4D phalangeal ratio, we performed sensitivity analyses in subjects without joint space narrowing in the second and fourth interphalangeal joints. RESULTS: We found no significant associations between 2D:4D length ratio and radiographic knee OA, severe symptomatic knee OA, or meniscal lesions. Low 2D:4D phalangeal ratio was associated with hand OA in women (OR 1.80, 95% CI 1.11-2.93), but in the sensitivity analysis, the association was attenuated (OR 1.35, 95% CI 0.79-2.32). Low 2D:4D phalangeal ratios were associated with knee injury in men (OR 1.78, 95% CI 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. CONCLUSION: Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee OA. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand OA in women.
@article{haugen_associations_2011,
title = {The associations between finger length pattern, osteoarthritis, and knee injury: data from the Framingham community cohort.},
volume = {63},
rights = {Copyright (c) 2011 by the American College of Rheumatology.},
issn = {1529-0131 0004-3591},
doi = {10.1002/art.30408},
abstract = {{OBJECTIVE}: To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis ({OA}), previous knee injury, and meniscal lesions in the general population. {METHODS}: We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging ({MRI}) were performed on subjects. Women and men were divided into tertiles according to their 2D:4D phalangeal and metacarpal ratios. We assessed the odds ratios ({ORs}) and 95\% confidence intervals (95\% {CIs}) for radiographic knee {OA}, severe symptomatic knee {OA}, radiographic hand {OA}, previous knee injury, and {MRI}-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand {OA} may affect the 2D:4D phalangeal ratio, we performed sensitivity analyses in subjects without joint space narrowing in the second and fourth interphalangeal joints. {RESULTS}: We found no significant associations between 2D:4D length ratio and radiographic knee {OA}, severe symptomatic knee {OA}, or meniscal lesions. Low 2D:4D phalangeal ratio was associated with hand {OA} in women ({OR} 1.80, 95\% {CI} 1.11-2.93), but in the sensitivity analysis, the association was attenuated ({OR} 1.35, 95\% {CI} 0.79-2.32). Low 2D:4D phalangeal ratios were associated with knee injury in men ({OR} 1.78, 95\% {CI} 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. {CONCLUSION}: Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee {OA}. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand {OA} in women.},
pages = {2284--2288},
number = {8},
journaltitle = {Arthritis and rheumatism},
shortjournal = {Arthritis Rheum},
author = {Haugen, Ida K. and Niu, Jingbo and Aliabadi, Piran and Felson, David T. and Englund, Martin},
date = {2011-08},
pmid = {21506096},
pmcid = {PMC3149773},
keywords = {Aged, Cohort Studies, Female, Fingers/*radiography, Hand/*radiography, Humans, Knee Injuries/*radiography, Male, Menisci, Tibial/injuries/*radiography, Middle Aged, Osteoarthritis/*radiography, Risk Factors}
}
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{"_id":"nLGQM2AihgKaLJLge","bibbaseid":"haugen-niu-aliabadi-felson-englund-theassociationsbetweenfingerlengthpatternosteoarthritisandkneeinjurydatafromtheframinghamcommunitycohort","downloads":0,"creationDate":"2017-03-31T11:02:37.072Z","title":"The associations between finger length pattern, osteoarthritis, and knee injury: data from the Framingham community cohort.","author_short":["Haugen, I. K.","Niu, J.","Aliabadi, P.","Felson, D. T.","Englund, M."],"year":null,"bibtype":"article","biburl":"http://clinicalepidemiology.se/ClinEpi_LU.bib","bibdata":{"bibtype":"article","type":"article","title":"The associations between finger length pattern, osteoarthritis, and knee injury: data from the Framingham community cohort.","volume":"63","rights":"Copyright (c) 2011 by the American College of Rheumatology.","issn":"1529-0131 0004-3591","doi":"10.1002/art.30408","abstract":"OBJECTIVE: To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis (OA), previous knee injury, and meniscal lesions in the general population. METHODS: We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging (MRI) were performed on subjects. Women and men were divided into tertiles according to their 2D:4D phalangeal and metacarpal ratios. We assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for radiographic knee OA, severe symptomatic knee OA, radiographic hand OA, previous knee injury, and MRI-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand OA may affect the 2D:4D phalangeal ratio, we performed sensitivity analyses in subjects without joint space narrowing in the second and fourth interphalangeal joints. RESULTS: We found no significant associations between 2D:4D length ratio and radiographic knee OA, severe symptomatic knee OA, or meniscal lesions. Low 2D:4D phalangeal ratio was associated with hand OA in women (OR 1.80, 95% CI 1.11-2.93), but in the sensitivity analysis, the association was attenuated (OR 1.35, 95% CI 0.79-2.32). Low 2D:4D phalangeal ratios were associated with knee injury in men (OR 1.78, 95% CI 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. CONCLUSION: Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee OA. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand OA in women.","pages":"2284--2288","number":"8","journaltitle":"Arthritis and rheumatism","shortjournal":"Arthritis Rheum","author":[{"propositions":[],"lastnames":["Haugen"],"firstnames":["Ida","K."],"suffixes":[]},{"propositions":[],"lastnames":["Niu"],"firstnames":["Jingbo"],"suffixes":[]},{"propositions":[],"lastnames":["Aliabadi"],"firstnames":["Piran"],"suffixes":[]},{"propositions":[],"lastnames":["Felson"],"firstnames":["David","T."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]}],"date":"2011-08","pmid":"21506096","pmcid":"PMC3149773","keywords":"Aged, Cohort Studies, Female, Fingers/*radiography, Hand/*radiography, Humans, Knee Injuries/*radiography, Male, Menisci, Tibial/injuries/*radiography, Middle Aged, Osteoarthritis/*radiography, Risk Factors","bibtex":"@article{haugen_associations_2011,\n\ttitle = {The associations between finger length pattern, osteoarthritis, and knee injury: data from the Framingham community cohort.},\n\tvolume = {63},\n\trights = {Copyright (c) 2011 by the American College of Rheumatology.},\n\tissn = {1529-0131 0004-3591},\n\tdoi = {10.1002/art.30408},\n\tabstract = {{OBJECTIVE}: To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis ({OA}), previous knee injury, and meniscal lesions in the general population. {METHODS}: We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging ({MRI}) were performed on subjects. Women and men were divided into tertiles according to their 2D:4D phalangeal and metacarpal ratios. We assessed the odds ratios ({ORs}) and 95\\% confidence intervals (95\\% {CIs}) for radiographic knee {OA}, severe symptomatic knee {OA}, radiographic hand {OA}, previous knee injury, and {MRI}-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand {OA} may affect the 2D:4D phalangeal ratio, we performed sensitivity analyses in subjects without joint space narrowing in the second and fourth interphalangeal joints. {RESULTS}: We found no significant associations between 2D:4D length ratio and radiographic knee {OA}, severe symptomatic knee {OA}, or meniscal lesions. Low 2D:4D phalangeal ratio was associated with hand {OA} in women ({OR} 1.80, 95\\% {CI} 1.11-2.93), but in the sensitivity analysis, the association was attenuated ({OR} 1.35, 95\\% {CI} 0.79-2.32). Low 2D:4D phalangeal ratios were associated with knee injury in men ({OR} 1.78, 95\\% {CI} 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. {CONCLUSION}: Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee {OA}. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand {OA} in women.},\n\tpages = {2284--2288},\n\tnumber = {8},\n\tjournaltitle = {Arthritis and rheumatism},\n\tshortjournal = {Arthritis Rheum},\n\tauthor = {Haugen, Ida K. and Niu, Jingbo and Aliabadi, Piran and Felson, David T. and Englund, Martin},\n\tdate = {2011-08},\n\tpmid = {21506096},\n\tpmcid = {PMC3149773},\n\tkeywords = {Aged, Cohort Studies, Female, Fingers/*radiography, Hand/*radiography, Humans, Knee Injuries/*radiography, Male, Menisci, Tibial/injuries/*radiography, Middle Aged, Osteoarthritis/*radiography, Risk Factors}\n}\n\n","author_short":["Haugen, I. K.","Niu, J.","Aliabadi, P.","Felson, D. 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