The associations between finger length pattern, osteoarthritis, and knee injury: data from the Framingham community cohort. Haugen, I. K., Niu, J., Aliabadi, P., Felson, D. T., & Englund, M. 63(8):2284--2288.
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OBJECTIVE: To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis (OA), previous knee injury, and meniscal lesions in the general population. METHODS: We measured the length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging (MRI) were performed on subjects. Women and men were divided into tertiles according to their 2D:4D phalangeal and metacarpal ratios. We assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for radiographic knee OA, severe symptomatic knee OA, radiographic hand OA, previous knee injury, and MRI-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand OA may affect the 2D:4D phalangeal ratio, we performed sensitivity analyses in subjects without joint space narrowing in the second and fourth interphalangeal joints. RESULTS: We found no significant associations between 2D:4D length ratio and radiographic knee OA, severe symptomatic knee OA, or meniscal lesions. Low 2D:4D phalangeal ratio was associated with hand OA in women (OR 1.80, 95% CI 1.11-2.93), but in the sensitivity analysis, the association was attenuated (OR 1.35, 95% CI 0.79-2.32). Low 2D:4D phalangeal ratios were associated with knee injury in men (OR 1.78, 95% CI 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. CONCLUSION: Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee OA. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand OA in women.
@article{haugen_associations_2011,
	title = {The associations between finger length pattern, osteoarthritis, and knee injury:  data from the Framingham community cohort.},
	volume = {63},
	rights = {Copyright (c) 2011 by the American College of Rheumatology.},
	issn = {1529-0131 0004-3591},
	doi = {10.1002/art.30408},
	abstract = {{OBJECTIVE}: To investigate the associations of index finger-to-ring finger (2D:4D) length ratio with radiographic knee and hand osteoarthritis ({OA}), previous knee injury, and meniscal lesions in the general population. {METHODS}: We measured the  length of the right second and fourth phalangeal and metacarpal bones on hand radiographs from 1,020 randomly recruited subjects (ages 51-92 years). Knee radiography and magnetic resonance imaging ({MRI}) were performed on subjects. Women and men were divided into tertiles according to their 2D:4D phalangeal and  metacarpal ratios. We assessed the odds ratios ({ORs}) and 95\% confidence intervals (95\% {CIs}) for radiographic knee {OA}, severe symptomatic knee {OA}, radiographic hand {OA}, previous knee injury, and {MRI}-defined meniscal lesion, using logistic regression with adjustment for age and body mass index. Because hand {OA} may affect the 2D:4D phalangeal ratio, we performed sensitivity analyses in subjects  without joint space narrowing in the second and fourth interphalangeal joints. {RESULTS}: We found no significant associations between 2D:4D length ratio and radiographic knee {OA}, severe symptomatic knee {OA}, or meniscal lesions. Low 2D:4D  phalangeal ratio was associated with hand {OA} in women ({OR} 1.80, 95\% {CI} 1.11-2.93), but in the sensitivity analysis, the association was attenuated ({OR} 1.35, 95\% {CI} 0.79-2.32). Low 2D:4D phalangeal ratios were associated with knee injury in men ({OR} 1.78, 95\% {CI} 1.02-3.10). We found no significant associations for 2D:4D metacarpal ratios. {CONCLUSION}: Low 2D:4D phalangeal ratios in men are associated with knee injury, but we did not find any significant association with knee {OA}. Low 2D:4D length ratio may be a consequence, rather than a cause, of hand {OA} in women.},
	pages = {2284--2288},
	number = {8},
	journaltitle = {Arthritis and rheumatism},
	shortjournal = {Arthritis Rheum},
	author = {Haugen, Ida K. and Niu, Jingbo and Aliabadi, Piran and Felson, David T. and Englund, Martin},
	date = {2011-08},
	pmid = {21506096},
	pmcid = {PMC3149773},
	keywords = {Aged, Cohort Studies, Female, Fingers/*radiography, Hand/*radiography, Humans, Knee Injuries/*radiography, Male, Menisci, Tibial/injuries/*radiography, Middle Aged, Osteoarthritis/*radiography, Risk Factors}
}
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