@article{
 title = {The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains},
 type = {article},
 year = {2013},
 pages = {140-144},
 volume = {4},
 websites = {http://dx.doi.org/10.1039/C2MD20189E},
 publisher = {The Royal Society of Chemistry},
 id = {a47b4983-980f-3296-b401-6629390c41da},
 created = {2015-10-07T14:20:50.000Z},
 file_attached = {true},
 profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},
 last_modified = {2018-09-03T10:20:46.113Z},
 read = {false},
 starred = {true},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Hay2013},
 source_type = {Journal Article},
 private_publication = {false},
 abstract = {Simple 1-substituted 5- and 6-isoxazolyl-benzimidazoles have been shown to be potent inhibitors of the BET bromodomains with selectivity over the related bromodomain of CBP. The reported inhibitors were prepared from simple starting materials in two steps followed by separation of the regioisomers or regioselectively in three steps},
 bibtype = {article},
 author = {Hay, Duncan and Fedorov, Oleg and Filippakopoulos, Panagis and Martin, Sarah and Philpott, Martin and Picaud, Sarah and Hewings, David S. and Uttakar, Sagar and Heightman, Tom D. and Conway, Stuart J. and Knapp, Stefan and Brennan, Paul E.},
 doi = {10.1039/c2md20189e},
 journal = {MedChemComm},
 number = {1}
}

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