Multiarm Core Cross-Linked Star-Shaped Poly(2-oxazoline)s Using a Bisfunctional 2-Oxazoline Monomer. Hayes, G., Drain, B., & Becer, C. R. MACROMOLECULES, 55(1):146–155, January, 2022. doi abstract bibtex Poly(2-oxazoline)s are an attractive class of polymers that have a potential for biomedical applications. However, synthetic approaches for the preparation of 2-oxazoline-based star-shaped polymers are quite limited and are usually based on either end-capping of a living chain with a multifunctional terminator or utilizing a multifunctional initiator. Up until now, the use of a bis-oxazoline monomer as a cross-linking agent for the synthesis of core cross-linked star shaped poly(2-oxazoline) polymers has not been reported. Herein, we have developed a new bis-oxazoline cross-linker via a fast and efficient thiol click reaction with no catalyst and purification required. Moreover, we have utilized this cross-linker to prepare well-controlled core cross-linked star polymers with poly(2-oxazoline) arms in a straightforward manner. Synthesized star-shaped polymers were characterized in detail using an advanced gel permeation chromatography technique and were found to have a range of arms from \textless10 to over 1000. Furthermore, the effect of the reaction concentration, amount of cross-linker, and arm length on star formation were analyzed and the stars' potential for dihydroxyanthroquinone encapsulation was explored.
@article{hayes_multiarm_2022,
title = {Multiarm {Core} {Cross}-{Linked} {Star}-{Shaped} {Poly}(2-oxazoline)s {Using} a {Bisfunctional} 2-{Oxazoline} {Monomer}},
volume = {55},
issn = {0024-9297},
doi = {10.1021/acs.macromol.1c02245},
abstract = {Poly(2-oxazoline)s are an attractive class of polymers that have a potential for biomedical applications. However, synthetic approaches for the preparation of 2-oxazoline-based star-shaped polymers are quite limited and are usually based on either end-capping of a living chain with a multifunctional terminator or utilizing a multifunctional initiator. Up until now, the use of a bis-oxazoline monomer as a cross-linking agent for the synthesis of core cross-linked star shaped poly(2-oxazoline) polymers has not been reported. Herein, we have developed a new bis-oxazoline cross-linker via a fast and efficient thiol click reaction with no catalyst and purification required. Moreover, we have utilized this cross-linker to prepare well-controlled core cross-linked star polymers with poly(2-oxazoline) arms in a straightforward manner. Synthesized star-shaped polymers were characterized in detail using an advanced gel permeation chromatography technique and were found to have a range of arms from {\textless}10 to over 1000. Furthermore, the effect of the reaction concentration, amount of cross-linker, and arm length on star formation were analyzed and the stars' potential for dihydroxyanthroquinone encapsulation was explored.},
number = {1},
urldate = {2022-01-09},
journal = {MACROMOLECULES},
author = {Hayes, Graham and Drain, Ben and Becer, C. Remzi},
month = jan,
year = {2022},
pages = {146--155},
}
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