Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour. Hay-Schmidt, A., Finkielman, O., T., E., Jensen, B., A., H., Høgsbro, C., F., Bak Holm, J., Johansen, K., H., Jensen, T., K., Andrade, A., M., Swan, S., H., Bornehag, C., Brunak, S., Jegou, B., Kristiansen, K., & Kristensen, D., M. Reproduction (Cambridge, England), 154(2):145-152, 8, 2017.
![Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour. [pdf]](https://bibbase.org/img/filetypes/pdf.svg "pdf")
Paper ![Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website doi abstract bibtex
Paper Website doi abstract bibtex Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDN-POA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.
@article{
title = {Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour.},
type = {article},
year = {2017},
pages = {145-152},
volume = {154},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/28559473},
month = {8},
id = {ac2134b5-5b00-33f3-a6e0-2942cde8b9cb},
created = {2025-07-07T13:25:15.200Z},
file_attached = {true},
profile_id = {9c1a206b-6cfb-375e-a257-a4c31f5a0791},
group_id = {89bece75-0a7e-3035-98e1-71b82260b8e8},
last_modified = {2025-07-07T13:26:02.371Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {false},
hidden = {false},
private_publication = {false},
abstract = {Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDN-POA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.},
bibtype = {article},
author = {Hay-Schmidt, Anders and Finkielman, Olivia T Ejlstrup and Jensen, Benjamin A H and Høgsbro, Christine F and Bak Holm, Jacob and Johansen, Kristoffer Haurum and Jensen, Tina Kold and Andrade, Anderson Martino and Swan, Shanna H and Bornehag, Carl-gustaf and Brunak, Søren and Jegou, Bernard and Kristiansen, Karsten and Kristensen, David Møbjerg},
doi = {10.1530/REP-17-0165},
journal = {Reproduction (Cambridge, England)},
number = {2}
}Downloads: 0
{"_id":"ycTTXDsjA3WAKhZiN","bibbaseid":"hayschmidt-finkielman-jensen-hgsbro-bakholm-johansen-jensen-andrade-etal-prenatalexposuretoparacetamolacetaminophenandprecursoranilineimpairsmasculinisationofmalebrainandbehaviour-2017","author_short":["Hay-Schmidt, A.","Finkielman, O., T., E.","Jensen, B., A., H.","Høgsbro, C., F.","Bak Holm, J.","Johansen, K., H.","Jensen, T., K.","Andrade, A., M.","Swan, S., H.","Bornehag, C.","Brunak, S.","Jegou, B.","Kristiansen, K.","Kristensen, D., M."],"bibdata":{"title":"Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour.","type":"article","year":"2017","pages":"145-152","volume":"154","websites":"http://www.ncbi.nlm.nih.gov/pubmed/28559473","month":"8","id":"ac2134b5-5b00-33f3-a6e0-2942cde8b9cb","created":"2025-07-07T13:25:15.200Z","file_attached":"true","profile_id":"9c1a206b-6cfb-375e-a257-a4c31f5a0791","group_id":"89bece75-0a7e-3035-98e1-71b82260b8e8","last_modified":"2025-07-07T13:26:02.371Z","read":false,"starred":false,"authored":false,"confirmed":false,"hidden":false,"private_publication":false,"abstract":"Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDN-POA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.","bibtype":"article","author":"Hay-Schmidt, Anders and Finkielman, Olivia T Ejlstrup and Jensen, Benjamin A H and Høgsbro, Christine F and Bak Holm, Jacob and Johansen, Kristoffer Haurum and Jensen, Tina Kold and Andrade, Anderson Martino and Swan, Shanna H and Bornehag, Carl-gustaf and Brunak, Søren and Jegou, Bernard and Kristiansen, Karsten and Kristensen, David Møbjerg","doi":"10.1530/REP-17-0165","journal":"Reproduction (Cambridge, England)","number":"2","bibtex":"@article{\n title = {Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour.},\n type = {article},\n year = {2017},\n pages = {145-152},\n volume = {154},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/28559473},\n month = {8},\n id = {ac2134b5-5b00-33f3-a6e0-2942cde8b9cb},\n created = {2025-07-07T13:25:15.200Z},\n file_attached = {true},\n profile_id = {9c1a206b-6cfb-375e-a257-a4c31f5a0791},\n group_id = {89bece75-0a7e-3035-98e1-71b82260b8e8},\n last_modified = {2025-07-07T13:26:02.371Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {false},\n hidden = {false},\n private_publication = {false},\n abstract = {Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDN-POA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.},\n bibtype = {article},\n author = {Hay-Schmidt, Anders and Finkielman, Olivia T Ejlstrup and Jensen, Benjamin A H and Høgsbro, Christine F and Bak Holm, Jacob and Johansen, Kristoffer Haurum and Jensen, Tina Kold and Andrade, Anderson Martino and Swan, Shanna H and Bornehag, Carl-gustaf and Brunak, Søren and Jegou, Bernard and Kristiansen, Karsten and Kristensen, David Møbjerg},\n doi = {10.1530/REP-17-0165},\n journal = {Reproduction (Cambridge, England)},\n number = {2}\n}","author_short":["Hay-Schmidt, A.","Finkielman, O., T., E.","Jensen, B., A., H.","Høgsbro, C., F.","Bak Holm, J.","Johansen, K., H.","Jensen, T., K.","Andrade, A., M.","Swan, S., H.","Bornehag, C.","Brunak, S.","Jegou, B.","Kristiansen, K.","Kristensen, D., M."],"urls":{"Paper":"https://bibbase.org/service/mendeley/9c1a206b-6cfb-375e-a257-a4c31f5a0791/file/711a2fb2-b828-ba39-7ecb-985087e8cf23/Hay_Schmidt_et_al___2017___Prenatal_exposure_to_paracetamolacetaminophen_and_precursor_aniline_impairs_masculinisation_o.pdf.pdf","Website":"http://www.ncbi.nlm.nih.gov/pubmed/28559473"},"biburl":"https://bibbase.org/service/mendeley/9c1a206b-6cfb-375e-a257-a4c31f5a0791","bibbaseid":"hayschmidt-finkielman-jensen-hgsbro-bakholm-johansen-jensen-andrade-etal-prenatalexposuretoparacetamolacetaminophenandprecursoranilineimpairsmasculinisationofmalebrainandbehaviour-2017","role":"author","metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/service/mendeley/9c1a206b-6cfb-375e-a257-a4c31f5a0791","dataSources":["J8fbWsdsy3xAaB3pX","2252seNhipfTmjEBQ"],"keywords":[],"search_terms":["prenatal","exposure","paracetamol","acetaminophen","precursor","aniline","impairs","masculinisation","male","brain","behaviour","hay-schmidt","finkielman","jensen","høgsbro","bak holm","johansen","jensen","andrade","swan","bornehag","brunak","jegou","kristiansen","kristensen"],"title":"Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour.","year":2017}