Baseline Mass Resolution of Peptide Isobars: A Record for Molecular Mass Resolution

Baseline Mass Resolution of Peptide Isobars: A Record for Molecular Mass Resolution. He, F., Hendrickson, C. L., & Marshall, A. G. Anal Chem, 73(3):647–650, 2001.
doi abstract bibtex

Baseline resolution of two peptides, RVMRGMR and RSHRGHR, of neutral monoisotopic mass, ~ 904 Da, has been achieved by microelectrospray ionization Fourier transform ion cyclotron resonance mass spectrometry at a mass resolving power of ~3 300 000. The elemental compositions of these molecules differ by N4O vs S2H8 (0.000 45 Da), which is less than one electron's mass (0.000 55 Da)! This result establishes a new record for the smallest resolved mass difference between any two molecules. This achievement is made possible by a combination of high magnetic field (9.4 T), large-diameter (4-in.) Penning trap, and low ion density. The implications for proteomics based on accurate mass measurements are discussed briefly.

@Article{he01baseline,
  author    = {Fei He and Christopher L. Hendrickson and Alan G. Marshall},
  title     = {Baseline Mass Resolution of Peptide Isobars: A Record for Molecular Mass Resolution},
  journal   = {Anal Chem},
  year      = {2001},
  volume    = {73(3)},
  pages     = {647--650},
  abstract  = {Baseline resolution of two peptides, RVMRGMR and RSHRGHR, of neutral monoisotopic mass, ~ 904 Da, has been achieved by microelectrospray ionization Fourier transform ion cyclotron resonance mass spectrometry at a mass resolving power of ~3 300 000. The elemental compositions of these molecules differ by N4O vs S2H8 (0.000 45 Da), which is less than one electron's mass (0.000 55 Da)! This result establishes a new record for the smallest resolved mass difference between any two molecules. This achievement is made possible by a combination of high magnetic field (9.4 T), large-diameter (4-in.) Penning trap, and low ion density. The implications for proteomics based on accurate mass measurements are discussed briefly.},
  doi       = {10.1021/ac000973h},
  file      = {HeEtAl_BaselineMassResolution_AnalChem_2001.pdf:2001/HeEtAl_BaselineMassResolution_AnalChem_2001.pdf:PDF},
  owner     = {apervukh},
  timestamp = {2009.02.03},
}

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