Influenza and coronary artery disease: exploring a clinical association with myocardial infarction and analyzing the utility of vaccination in prevention of myocardial infarction. Hebsur, S., Vakil, E., Oetgen, W. J., Kumar, P. N., & Lazarous, D. F. Reviews in Cardiovascular Medicine, 15(2):168--175, 2014. abstract bibtex Both coronary artery disease and influenza outbreaks contribute significantly to worldwide morbidity and mortality. An increasing number of epidemiologic studies have concluded that a temporal association exists between acute viral illnesses and myocardial infarction. Viral illnesses such as influenza can cause or exacerbate coronary atherosclerosis by activating inflammatory pathways. Data from a large case-controlled trial and two randomized controlled trials suggest that influenza vaccination in patients with coronary artery disease may lead to a decrease in incidence, morbidity, and mortality from acute myocardial infarction. A meta-analysis of the two randomized controlled trials for cardiovascular death demonstrated a pooled relative risk of 0.39 (95% confidence interval, 0.20-0.77) for patients who received the influenza vaccine compared with placebo.
@article{ hebsur_influenza_2014,
title = {Influenza and coronary artery disease: exploring a clinical association with myocardial infarction and analyzing the utility of vaccination in prevention of myocardial infarction},
volume = {15},
issn = {1530-6550},
shorttitle = {Influenza and coronary artery disease},
abstract = {Both coronary artery disease and influenza outbreaks contribute significantly to worldwide morbidity and mortality. An increasing number of epidemiologic studies have concluded that a temporal association exists between acute viral illnesses and myocardial infarction. Viral illnesses such as influenza can cause or exacerbate coronary atherosclerosis by activating inflammatory pathways. Data from a large case-controlled trial and two randomized controlled trials suggest that influenza vaccination in patients with coronary artery disease may lead to a decrease in incidence, morbidity, and mortality from acute myocardial infarction. A meta-analysis of the two randomized controlled trials for cardiovascular death demonstrated a pooled relative risk of 0.39 (95% confidence interval, 0.20-0.77) for patients who received the influenza vaccine compared with placebo.},
language = {eng},
number = {2},
journal = {Reviews in Cardiovascular Medicine},
author = {Hebsur, Shrinivas and Vakil, Erik and Oetgen, William J. and Kumar, Princy N. and Lazarous, Daisy F.},
year = {2014},
pmid = {25051134},
keywords = {Humans, Inflammation, Influenza Vaccines, Influenza, Human, Myocardial Infarction, Prognosis, Risk Factors, Vaccination},
pages = {168--175}
}
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