Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT). Hecht, M., Blümle, A., Binder, H., Schumacher, M., & Binder, N. BMC Medical Research Methodology, 25(1):80, March, 2025.
Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT) [link]Paper  doi  abstract   bibtex   
The goal of evidence-based medicine is to make clinical decisions based on the best available, relevant evidence. For this to be possible, studies such as randomized controlled trials (RCTs), which are widely considered to provide the best evidence of all forms of primary research, must be visible and have an impact on clinical practice guidelines. We further investigated the impact of publicly and commercially sponsored RCTs on clinical practice guidelines by measuring direct and indirect impactful citations and the time to guideline impact.
@article{hecht_investigator-initiated_2025,
	title = {Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines ({IMPACT})},
	volume = {25},
	issn = {1471-2288},
	url = {https://doi.org/10.1186/s12874-025-02535-z},
	doi = {10.1186/s12874-025-02535-z},
	abstract = {The goal of evidence-based medicine is to make clinical decisions based on the best available, relevant evidence. For this to be possible, studies such as randomized controlled trials (RCTs), which are widely considered to provide the best evidence of all forms of primary research, must be visible and have an impact on clinical practice guidelines. We further investigated the impact of publicly and commercially sponsored RCTs on clinical practice guidelines by measuring direct and indirect impactful citations and the time to guideline impact.},
	number = {1},
	urldate = {2025-04-07},
	journal = {BMC Medical Research Methodology},
	author = {Hecht, Manuel and Blümle, Anette and Binder, Harald and Schumacher, Martin and Binder, Nadine},
	month = mar,
	year = {2025},
	keywords = {Libre accès},
	pages = {80},
	file = {Full Text PDF:/Users/jd/Zotero/storage/2HKLFWS4/Hecht et al. - 2025 - Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized con.pdf:application/pdf;Snapshot:/Users/jd/Zotero/storage/TJZRH72D/s12874-025-02535-z.html:text/html},
}

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