@article{RN6043,
   author = {Heffernan, A. E. and Wu, Y. and Benz, L. S. and Verhaak, R. G. W. and Kwan, B. M. and Claus, E. B.},
   title = {Quality of life after surgery for lower grade gliomas},
   journal = {Cancer},
   note = {1097-0142
Heffernan, Anne E
Orcid: 0009-0009-9043-3750
Wu, Yilun
Benz, Luke S
Verhaak, Roel G W
Kwan, Bethany M
Claus, Elizabeth B
CA109475/CA/NCI NIH HHS/United States
CA109745/CA/NCI NIH HHS/United States
R01s CA109468/CA/NCI NIH HHS/United States
CA108473/CA/NCI NIH HHS/United States
U2C CA252979/CA/NCI NIH HHS/United States
CA109461/CA/NCI NIH HHS/United States
Journal Article
United States
2023/08/21
Cancer. 2023 Aug 20. doi: 10.1002/cncr.34980.},
   abstract = {BACKGROUND: Few large studies have investigated quality of life (QOL) for adults diagnosed with lower grade glioma (LGG). METHODS: QOL was assessed for 320 adults with LGG (World Health Organization grade 2/3) enrolled in the International Low Grade Glioma Registry by using the Medical Outcomes Study 36-Item Short Form health survey. Data on symptoms were also collected. QOL outcomes were examined by treatment group and also compared to those from a population-based case-control study of meningioma (the Meningioma Consortium), in which 1722 meningioma cases diagnosed among residents of Connecticut, Massachusetts, California, Texas, and North Carolina from May 1, 2006 through March 14, 2013 were enrolled and frequency matched to 1622 controls by age, sex, and geography. RESULTS: The LGG sample average age is 45 years at the time of interview and 53.1% male. Almost 55% of patients had received radiation and chemotherapy (primarily temozolomide); 32.4% had received neither treatment. Two-thirds of participants with LGG report difficulty with speaking, memory, or thinking, and over one of three reports personality change or difficulty driving. After controlling for age and other comorbidities, individuals with LGG report levels of physical, emotional, and mental health functioning below those reported in a meningioma as well as a general healthy population. CONCLUSIONS: Despite being relatively young, persons with LGG report significantly reduced QOL compared to persons with nonmalignant brain tumors and to a control population, which highlights the need to better acknowledge and manage these symptoms for this group of patients diagnosed in the prime of life.},
   keywords = {astrocytoma
lower grade glioma
neuro-oncology
oligodendroglioma
quality of life
rehabilitation
symptom management},
   ISSN = {0008-543x},
   DOI = {10.1002/cncr.34980},
   year = {2023},
   type = {Journal Article}
}

{"_id":"qwtonPHSehwirepL8","bibbaseid":"heffernan-wu-benz-verhaak-kwan-claus-qualityoflifeaftersurgeryforlowergradegliomas-2023","author_short":["Heffernan, A. E.","Wu, Y.","Benz, L. S.","Verhaak, R. G. W.","Kwan, B. M.","Claus, E. B."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Heffernan"],"firstnames":["A.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Wu"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Benz"],"firstnames":["L.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Verhaak"],"firstnames":["R.","G.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Kwan"],"firstnames":["B.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Claus"],"firstnames":["E.","B."],"suffixes":[]}],"title":"Quality of life after surgery for lower grade gliomas","journal":"Cancer","note":"1097-0142 Heffernan, Anne E Orcid: 0009-0009-9043-3750 Wu, Yilun Benz, Luke S Verhaak, Roel G W Kwan, Bethany M Claus, Elizabeth B CA109475/CA/NCI NIH HHS/United States CA109745/CA/NCI NIH HHS/United States R01s CA109468/CA/NCI NIH HHS/United States CA108473/CA/NCI NIH HHS/United States U2C CA252979/CA/NCI NIH HHS/United States CA109461/CA/NCI NIH HHS/United States Journal Article United States 2023/08/21 Cancer. 2023 Aug 20. doi: 10.1002/cncr.34980.","abstract":"BACKGROUND: Few large studies have investigated quality of life (QOL) for adults diagnosed with lower grade glioma (LGG). METHODS: QOL was assessed for 320 adults with LGG (World Health Organization grade 2/3) enrolled in the International Low Grade Glioma Registry by using the Medical Outcomes Study 36-Item Short Form health survey. Data on symptoms were also collected. QOL outcomes were examined by treatment group and also compared to those from a population-based case-control study of meningioma (the Meningioma Consortium), in which 1722 meningioma cases diagnosed among residents of Connecticut, Massachusetts, California, Texas, and North Carolina from May 1, 2006 through March 14, 2013 were enrolled and frequency matched to 1622 controls by age, sex, and geography. RESULTS: The LGG sample average age is 45 years at the time of interview and 53.1% male. Almost 55% of patients had received radiation and chemotherapy (primarily temozolomide); 32.4% had received neither treatment. Two-thirds of participants with LGG report difficulty with speaking, memory, or thinking, and over one of three reports personality change or difficulty driving. After controlling for age and other comorbidities, individuals with LGG report levels of physical, emotional, and mental health functioning below those reported in a meningioma as well as a general healthy population. CONCLUSIONS: Despite being relatively young, persons with LGG report significantly reduced QOL compared to persons with nonmalignant brain tumors and to a control population, which highlights the need to better acknowledge and manage these symptoms for this group of patients diagnosed in the prime of life.","keywords":"astrocytoma lower grade glioma neuro-oncology oligodendroglioma quality of life rehabilitation symptom management","issn":"0008-543x","doi":"10.1002/cncr.34980","year":"2023","bibtex":"@article{RN6043,\n author = {Heffernan, A. E. and Wu, Y. and Benz, L. S. and Verhaak, R. G. W. and Kwan, B. M. and Claus, E. B.},\n title = {Quality of life after surgery for lower grade gliomas},\n journal = {Cancer},\n note = {1097-0142\nHeffernan, Anne E\nOrcid: 0009-0009-9043-3750\nWu, Yilun\nBenz, Luke S\nVerhaak, Roel G W\nKwan, Bethany M\nClaus, Elizabeth B\nCA109475/CA/NCI NIH HHS/United States\nCA109745/CA/NCI NIH HHS/United States\nR01s CA109468/CA/NCI NIH HHS/United States\nCA108473/CA/NCI NIH HHS/United States\nU2C CA252979/CA/NCI NIH HHS/United States\nCA109461/CA/NCI NIH HHS/United States\nJournal Article\nUnited States\n2023/08/21\nCancer. 2023 Aug 20. doi: 10.1002/cncr.34980.},\n abstract = {BACKGROUND: Few large studies have investigated quality of life (QOL) for adults diagnosed with lower grade glioma (LGG). METHODS: QOL was assessed for 320 adults with LGG (World Health Organization grade 2/3) enrolled in the International Low Grade Glioma Registry by using the Medical Outcomes Study 36-Item Short Form health survey. Data on symptoms were also collected. QOL outcomes were examined by treatment group and also compared to those from a population-based case-control study of meningioma (the Meningioma Consortium), in which 1722 meningioma cases diagnosed among residents of Connecticut, Massachusetts, California, Texas, and North Carolina from May 1, 2006 through March 14, 2013 were enrolled and frequency matched to 1622 controls by age, sex, and geography. RESULTS: The LGG sample average age is 45 years at the time of interview and 53.1% male. Almost 55% of patients had received radiation and chemotherapy (primarily temozolomide); 32.4% had received neither treatment. Two-thirds of participants with LGG report difficulty with speaking, memory, or thinking, and over one of three reports personality change or difficulty driving. After controlling for age and other comorbidities, individuals with LGG report levels of physical, emotional, and mental health functioning below those reported in a meningioma as well as a general healthy population. CONCLUSIONS: Despite being relatively young, persons with LGG report significantly reduced QOL compared to persons with nonmalignant brain tumors and to a control population, which highlights the need to better acknowledge and manage these symptoms for this group of patients diagnosed in the prime of life.},\n keywords = {astrocytoma\nlower grade glioma\nneuro-oncology\noligodendroglioma\nquality of life\nrehabilitation\nsymptom management},\n ISSN = {0008-543x},\n DOI = {10.1002/cncr.34980},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["Heffernan, A. E.","Wu, Y.","Benz, L. S.","Verhaak, R. G. W.","Kwan, B. M.","Claus, E. B."],"key":"RN6043","id":"RN6043","bibbaseid":"heffernan-wu-benz-verhaak-kwan-claus-qualityoflifeaftersurgeryforlowergradegliomas-2023","role":"author","urls":{},"keyword":["astrocytoma lower grade glioma neuro-oncology oligodendroglioma quality of life rehabilitation symptom management"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://verhaaklab.com/files/verhaak.bib","dataSources":["iFXeF2qjAL2y5TeTz"],"keywords":["astrocytoma lower grade glioma neuro-oncology oligodendroglioma quality of life rehabilitation symptom management"],"search_terms":["quality","life","surgery","lower","grade","gliomas","heffernan","wu","benz","verhaak","kwan","claus"],"title":"Quality of life after surgery for lower grade gliomas","year":2023}