Aggregated time intensity curves after transarterial chemoembolization with degradable starch microspheres: a feasibility study. Heibl, M., Jung, E., M., Beyer, L., Wohlgemuth, W., A., Stroszczynski, C., & Wiggermann, P. Clinical hemorheology and microcirculation, 55(4):417-21, 1, 2013.
Aggregated time intensity curves after transarterial chemoembolization with degradable starch microspheres: a feasibility study. [link]Website  abstract   bibtex   
PURPOSE To evaluate tumor perfusion by means of dynamic contrast-enhanced ultrasonography (DCEUS) and aggregated time intensity curves (TICs) after transarterial chemoembolization with degradable starch microspheres (DSM-TACE). MATERIAL AND METHODS 18 patients underwent 36 DCEUS examinations conducted via contrast agent application before and after DSM-TACE. Based on time intensity curves (TICs), we analyzed the microcirculation of the embolized HCC lesions with a dedicated perfusion software. RESULTS Signal intensity was significantly reduced (p ≤ 0.001) after DSM-TACE at all time points measured. The mean signal intensity after 5, 10, 15, 20 and 25 s was 375.18 ± 16.41, 455.66 ± 17.92, 294.47 ± 19.91, 246.51 ± 20.99 and 173.45 ± 25.80 before TACE and 49.47 ± 2.43, 49.51 ± 2.40, 37.40 ± 2.45, 27.48 ± 2.65 and 27.96 ± 3.01 after TACE. CONCLUSION In this study, tumor perfusion could be accurately evaluated by means of DCEUS and aggregated TICs after DSM-TACE.
@article{
 title = {Aggregated time intensity curves after transarterial chemoembolization with degradable starch microspheres: a feasibility study.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {DCE-US,DSM-TACE,HCC,TIC},
 pages = {417-21},
 volume = {55},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/24113498},
 month = {1},
 day = {1},
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 accessed = {2017-04-20},
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 abstract = {PURPOSE To evaluate tumor perfusion by means of dynamic contrast-enhanced ultrasonography (DCEUS) and aggregated time intensity curves (TICs) after transarterial chemoembolization with degradable starch microspheres (DSM-TACE). MATERIAL AND METHODS 18 patients underwent 36 DCEUS examinations conducted via contrast agent application before and after DSM-TACE. Based on time intensity curves (TICs), we analyzed the microcirculation of the embolized HCC lesions with a dedicated perfusion software. RESULTS Signal intensity was significantly reduced (p ≤ 0.001) after DSM-TACE at all time points measured. The mean signal intensity after 5, 10, 15, 20 and 25 s was 375.18 ± 16.41, 455.66 ± 17.92, 294.47 ± 19.91, 246.51 ± 20.99 and 173.45 ± 25.80 before TACE and 49.47 ± 2.43, 49.51 ± 2.40, 37.40 ± 2.45, 27.48 ± 2.65 and 27.96 ± 3.01 after TACE. CONCLUSION In this study, tumor perfusion could be accurately evaluated by means of DCEUS and aggregated TICs after DSM-TACE.},
 bibtype = {article},
 author = {Heibl, M and Jung, E M and Beyer, L and Wohlgemuth, W A and Stroszczynski, C and Wiggermann, P},
 journal = {Clinical hemorheology and microcirculation},
 number = {4}
}

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