The relation between endometriosis and ovarian cancer - a review. Heidemann, L. N., Hartwell, D., Heidemann, C. H., & Jochumsen, K. M. Acta Obstetricia Et Gynecologica Scandinavica, 93(1):20--31, January, 2014. doi abstract bibtex BACKGROUND: Endometriosis is known to harbor characteristics substantiating its possible role as a precursor of ovarian cancer. OBJECTIVE: To assess the quality of the literature regarding the association between endometriosis and ovarian cancer and to estimate the extent of this relation. METHODS: An electronic literature search was conducted in PubMed and 1112 articles dealing with the relation between endometriosis and ovarian cancer were identified. Original articles based on case-control studies, cohort studies and cross-sectional studies were included. Studies consisting of populations with self-reported endometriosis were excluded, as were articles with fewer than 20 cases of ovarian cancer. Twenty-eight studies underwent detailed quality assessments based on the checklists developed by the Scottish Intercollegiate Guidelines Network (SIGN). Meta-analyses were conducted on selected subgroups of ovarian cancer with coexisting endometriosis. RESULTS: None of the 28 studies was given the highest possible rating using the SIGN checklists. The risk of ovarian cancer in women with endometriosis was reported to be a standardized incidence ratio of 1.43-8.95, a rate ratio of 1.6-2.88, an odds ratio of 1.34, with a prevalence of ovarian cancer in 2.0-17.0% of women with endometriosis. Conversely, the prevalence of endometriosis in women with ovarian cancer ranged from 3.4 to 52.6%. Meta-analysis results were weakened by heterogeneity. CONCLUSION: There is sufficient evidence to conclude that there is an increased risk of developing clear-cell and endometrioid epithelial ovarian cancer for women with histologically verified endometriosis. Nonetheless, prospective cohort studies assessing the relation between endometriosis and ovarian cancer will increase knowledge in this field.
@article{heidemann_relation_2014,
title = {The relation between endometriosis and ovarian cancer - a review},
volume = {93},
issn = {1600-0412},
doi = {10.1111/aogs.12255},
abstract = {BACKGROUND: Endometriosis is known to harbor characteristics substantiating its possible role as a precursor of ovarian cancer.
OBJECTIVE: To assess the quality of the literature regarding the association between endometriosis and ovarian cancer and to estimate the extent of this relation.
METHODS: An electronic literature search was conducted in PubMed and 1112 articles dealing with the relation between endometriosis and ovarian cancer were identified. Original articles based on case-control studies, cohort studies and cross-sectional studies were included. Studies consisting of populations with self-reported endometriosis were excluded, as were articles with fewer than 20 cases of ovarian cancer. Twenty-eight studies underwent detailed quality assessments based on the checklists developed by the Scottish Intercollegiate Guidelines Network (SIGN). Meta-analyses were conducted on selected subgroups of ovarian cancer with coexisting endometriosis.
RESULTS: None of the 28 studies was given the highest possible rating using the SIGN checklists. The risk of ovarian cancer in women with endometriosis was reported to be a standardized incidence ratio of 1.43-8.95, a rate ratio of 1.6-2.88, an odds ratio of 1.34, with a prevalence of ovarian cancer in 2.0-17.0\% of women with endometriosis. Conversely, the prevalence of endometriosis in women with ovarian cancer ranged from 3.4 to 52.6\%. Meta-analysis results were weakened by heterogeneity.
CONCLUSION: There is sufficient evidence to conclude that there is an increased risk of developing clear-cell and endometrioid epithelial ovarian cancer for women with histologically verified endometriosis. Nonetheless, prospective cohort studies assessing the relation between endometriosis and ovarian cancer will increase knowledge in this field.},
language = {eng},
number = {1},
journal = {Acta Obstetricia Et Gynecologica Scandinavica},
author = {Heidemann, Lene N. and Hartwell, Dorthe and Heidemann, Christian H. and Jochumsen, Kirsten M.},
month = jan,
year = {2014},
pmid = {24011403},
keywords = {Endometriosis, Female, Humans, Incidence, Ovarian Neoplasms, Prevalence, Risk, meta-analysis, ovarian cancer, review},
pages = {20--31}
}
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OBJECTIVE: To assess the quality of the literature regarding the association between endometriosis and ovarian cancer and to estimate the extent of this relation. METHODS: An electronic literature search was conducted in PubMed and 1112 articles dealing with the relation between endometriosis and ovarian cancer were identified. Original articles based on case-control studies, cohort studies and cross-sectional studies were included. Studies consisting of populations with self-reported endometriosis were excluded, as were articles with fewer than 20 cases of ovarian cancer. Twenty-eight studies underwent detailed quality assessments based on the checklists developed by the Scottish Intercollegiate Guidelines Network (SIGN). Meta-analyses were conducted on selected subgroups of ovarian cancer with coexisting endometriosis. RESULTS: None of the 28 studies was given the highest possible rating using the SIGN checklists. The risk of ovarian cancer in women with endometriosis was reported to be a standardized incidence ratio of 1.43-8.95, a rate ratio of 1.6-2.88, an odds ratio of 1.34, with a prevalence of ovarian cancer in 2.0-17.0% of women with endometriosis. Conversely, the prevalence of endometriosis in women with ovarian cancer ranged from 3.4 to 52.6%. Meta-analysis results were weakened by heterogeneity. CONCLUSION: There is sufficient evidence to conclude that there is an increased risk of developing clear-cell and endometrioid epithelial ovarian cancer for women with histologically verified endometriosis. Nonetheless, prospective cohort studies assessing the relation between endometriosis and ovarian cancer will increase knowledge in this field.","language":"eng","number":"1","journal":"Acta Obstetricia Et Gynecologica Scandinavica","author":[{"propositions":[],"lastnames":["Heidemann"],"firstnames":["Lene","N."],"suffixes":[]},{"propositions":[],"lastnames":["Hartwell"],"firstnames":["Dorthe"],"suffixes":[]},{"propositions":[],"lastnames":["Heidemann"],"firstnames":["Christian","H."],"suffixes":[]},{"propositions":[],"lastnames":["Jochumsen"],"firstnames":["Kirsten","M."],"suffixes":[]}],"month":"January","year":"2014","pmid":"24011403","keywords":"Endometriosis, Female, Humans, Incidence, Ovarian Neoplasms, Prevalence, Risk, meta-analysis, ovarian cancer, review","pages":"20--31","bibtex":"@article{heidemann_relation_2014,\n\ttitle = {The relation between endometriosis and ovarian cancer - a review},\n\tvolume = {93},\n\tissn = {1600-0412},\n\tdoi = {10.1111/aogs.12255},\n\tabstract = {BACKGROUND: Endometriosis is known to harbor characteristics substantiating its possible role as a precursor of ovarian cancer.\nOBJECTIVE: To assess the quality of the literature regarding the association between endometriosis and ovarian cancer and to estimate the extent of this relation.\nMETHODS: An electronic literature search was conducted in PubMed and 1112 articles dealing with the relation between endometriosis and ovarian cancer were identified. Original articles based on case-control studies, cohort studies and cross-sectional studies were included. Studies consisting of populations with self-reported endometriosis were excluded, as were articles with fewer than 20 cases of ovarian cancer. Twenty-eight studies underwent detailed quality assessments based on the checklists developed by the Scottish Intercollegiate Guidelines Network (SIGN). Meta-analyses were conducted on selected subgroups of ovarian cancer with coexisting endometriosis.\nRESULTS: None of the 28 studies was given the highest possible rating using the SIGN checklists. The risk of ovarian cancer in women with endometriosis was reported to be a standardized incidence ratio of 1.43-8.95, a rate ratio of 1.6-2.88, an odds ratio of 1.34, with a prevalence of ovarian cancer in 2.0-17.0\\% of women with endometriosis. Conversely, the prevalence of endometriosis in women with ovarian cancer ranged from 3.4 to 52.6\\%. 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