The relation between endometriosis and ovarian cancer - a review. Heidemann, L. N., Hartwell, D., Heidemann, C. H., & Jochumsen, K. M. Acta Obstetricia Et Gynecologica Scandinavica, 93(1):20--31, January, 2014.
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BACKGROUND: Endometriosis is known to harbor characteristics substantiating its possible role as a precursor of ovarian cancer. OBJECTIVE: To assess the quality of the literature regarding the association between endometriosis and ovarian cancer and to estimate the extent of this relation. METHODS: An electronic literature search was conducted in PubMed and 1112 articles dealing with the relation between endometriosis and ovarian cancer were identified. Original articles based on case-control studies, cohort studies and cross-sectional studies were included. Studies consisting of populations with self-reported endometriosis were excluded, as were articles with fewer than 20 cases of ovarian cancer. Twenty-eight studies underwent detailed quality assessments based on the checklists developed by the Scottish Intercollegiate Guidelines Network (SIGN). Meta-analyses were conducted on selected subgroups of ovarian cancer with coexisting endometriosis. RESULTS: None of the 28 studies was given the highest possible rating using the SIGN checklists. The risk of ovarian cancer in women with endometriosis was reported to be a standardized incidence ratio of 1.43-8.95, a rate ratio of 1.6-2.88, an odds ratio of 1.34, with a prevalence of ovarian cancer in 2.0-17.0% of women with endometriosis. Conversely, the prevalence of endometriosis in women with ovarian cancer ranged from 3.4 to 52.6%. Meta-analysis results were weakened by heterogeneity. CONCLUSION: There is sufficient evidence to conclude that there is an increased risk of developing clear-cell and endometrioid epithelial ovarian cancer for women with histologically verified endometriosis. Nonetheless, prospective cohort studies assessing the relation between endometriosis and ovarian cancer will increase knowledge in this field.
@article{heidemann_relation_2014,
	title = {The relation between endometriosis and ovarian cancer - a review},
	volume = {93},
	issn = {1600-0412},
	doi = {10.1111/aogs.12255},
	abstract = {BACKGROUND: Endometriosis is known to harbor characteristics substantiating its possible role as a precursor of ovarian cancer.
OBJECTIVE: To assess the quality of the literature regarding the association between endometriosis and ovarian cancer and to estimate the extent of this relation.
METHODS: An electronic literature search was conducted in PubMed and 1112 articles dealing with the relation between endometriosis and ovarian cancer were identified. Original articles based on case-control studies, cohort studies and cross-sectional studies were included. Studies consisting of populations with self-reported endometriosis were excluded, as were articles with fewer than 20 cases of ovarian cancer. Twenty-eight studies underwent detailed quality assessments based on the checklists developed by the Scottish Intercollegiate Guidelines Network (SIGN). Meta-analyses were conducted on selected subgroups of ovarian cancer with coexisting endometriosis.
RESULTS: None of the 28 studies was given the highest possible rating using the SIGN checklists. The risk of ovarian cancer in women with endometriosis was reported to be a standardized incidence ratio of 1.43-8.95, a rate ratio of 1.6-2.88, an odds ratio of 1.34, with a prevalence of ovarian cancer in 2.0-17.0\% of women with endometriosis. Conversely, the prevalence of endometriosis in women with ovarian cancer ranged from 3.4 to 52.6\%. Meta-analysis results were weakened by heterogeneity.
CONCLUSION: There is sufficient evidence to conclude that there is an increased risk of developing clear-cell and endometrioid epithelial ovarian cancer for women with histologically verified endometriosis. Nonetheless, prospective cohort studies assessing the relation between endometriosis and ovarian cancer will increase knowledge in this field.},
	language = {eng},
	number = {1},
	journal = {Acta Obstetricia Et Gynecologica Scandinavica},
	author = {Heidemann, Lene N. and Hartwell, Dorthe and Heidemann, Christian H. and Jochumsen, Kirsten M.},
	month = jan,
	year = {2014},
	pmid = {24011403},
	keywords = {Endometriosis, Female, Humans, Incidence, Ovarian Neoplasms, Prevalence, Risk, meta-analysis, ovarian cancer, review},
	pages = {20--31}
}

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