Vitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis. Hemilä, H. BMJ Open, 3(6):e002416, June, 2013. Publisher: British Medical Journal Publishing Group Section: Respiratory medicine![Vitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Objective To determine whether vitamin C administration influences exercise-induced bronchoconstriction (EIB). Design Systematic review and meta-analysis. Methods MEDLINE and Scopus were searched for placebo-controlled trials on vitamin C and EIB. The primary measures of vitamin C effect used in this study were: (1) the arithmetic difference and (2) the relative effect in the postexercise forced expiratory volume in 1 s (FEV1) decline between the vitamin C and placebo periods. The relative effect of vitamin C administration on FEV1 was analysed by using linear modelling for two studies that reported full or partial individual-level data. The arithmetic differences and the relative effects were pooled by the inverse variance method. A secondary measure of the vitamin C effect was the difference in the proportion of participants suffering from EIB on the vitamin C and placebo days. Results 3 placebo-controlled trials that studied the effect of vitamin C on EIB were identified. In all, they had 40 participants. The pooled effect estimate indicated a reduction of 8.4 percentage points (95% CI 4.6 to 12) in the postexercise FEV1 decline when vitamin C was administered before exercise. The pooled relative effect estimate indicated a 48% reduction (95% CI 33% to 64%) in the postexercise FEV1 decline when vitamin C was administered before exercise. One study needed imputations to include it in the meta-analyses, but it also reported that vitamin C decreased the proportion of participants who suffered from EIB by 50 percentage points (95% CI 23 to 68); this comparison did not need data imputations. Conclusions Given the safety and low cost of vitamin C, and the positive findings for vitamin C administration in the three EIB studies, it seems reasonable for physically active people to test vitamin C when they have respiratory symptoms such as cough associated with exercise. Further research on the effects of vitamin C on EIB is warranted.
@article{hemila_vitamin_2013,
title = {Vitamin {C} may alleviate exercise-induced bronchoconstriction: a meta-analysis},
volume = {3},
copyright = {Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode},
issn = {2044-6055, 2044-6055},
shorttitle = {Vitamin {C} may alleviate exercise-induced bronchoconstriction},
url = {https://bmjopen.bmj.com/content/3/6/e002416},
doi = {10.1136/bmjopen-2012-002416},
abstract = {Objective To determine whether vitamin C administration influences exercise-induced bronchoconstriction (EIB).
Design Systematic review and meta-analysis.
Methods MEDLINE and Scopus were searched for placebo-controlled trials on vitamin C and EIB. The primary measures of vitamin C effect used in this study were: (1) the arithmetic difference and (2) the relative effect in the postexercise forced expiratory volume in 1 s (FEV1) decline between the vitamin C and placebo periods. The relative effect of vitamin C administration on FEV1 was analysed by using linear modelling for two studies that reported full or partial individual-level data. The arithmetic differences and the relative effects were pooled by the inverse variance method. A secondary measure of the vitamin C effect was the difference in the proportion of participants suffering from EIB on the vitamin C and placebo days.
Results 3 placebo-controlled trials that studied the effect of vitamin C on EIB were identified. In all, they had 40 participants. The pooled effect estimate indicated a reduction of 8.4 percentage points (95\% CI 4.6 to 12) in the postexercise FEV1 decline when vitamin C was administered before exercise. The pooled relative effect estimate indicated a 48\% reduction (95\% CI 33\% to 64\%) in the postexercise FEV1 decline when vitamin C was administered before exercise. One study needed imputations to include it in the meta-analyses, but it also reported that vitamin C decreased the proportion of participants who suffered from EIB by 50 percentage points (95\% CI 23 to 68); this comparison did not need data imputations.
Conclusions Given the safety and low cost of vitamin C, and the positive findings for vitamin C administration in the three EIB studies, it seems reasonable for physically active people to test vitamin C when they have respiratory symptoms such as cough associated with exercise. Further research on the effects of vitamin C on EIB is warranted.},
language = {en},
number = {6},
urldate = {2020-03-31},
journal = {BMJ Open},
author = {Hemilä, Harri},
month = jun,
year = {2013},
pmid = {23794586},
note = {Publisher: British Medical Journal Publishing Group
Section: Respiratory medicine},
keywords = {Nutrition \& Dietetics, Sports Medicine},
pages = {e002416},
}
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See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode","issn":"2044-6055, 2044-6055","shorttitle":"Vitamin C may alleviate exercise-induced bronchoconstriction","url":"https://bmjopen.bmj.com/content/3/6/e002416","doi":"10.1136/bmjopen-2012-002416","abstract":"Objective To determine whether vitamin C administration influences exercise-induced bronchoconstriction (EIB). Design Systematic review and meta-analysis. Methods MEDLINE and Scopus were searched for placebo-controlled trials on vitamin C and EIB. The primary measures of vitamin C effect used in this study were: (1) the arithmetic difference and (2) the relative effect in the postexercise forced expiratory volume in 1 s (FEV1) decline between the vitamin C and placebo periods. The relative effect of vitamin C administration on FEV1 was analysed by using linear modelling for two studies that reported full or partial individual-level data. The arithmetic differences and the relative effects were pooled by the inverse variance method. A secondary measure of the vitamin C effect was the difference in the proportion of participants suffering from EIB on the vitamin C and placebo days. Results 3 placebo-controlled trials that studied the effect of vitamin C on EIB were identified. In all, they had 40 participants. The pooled effect estimate indicated a reduction of 8.4 percentage points (95% CI 4.6 to 12) in the postexercise FEV1 decline when vitamin C was administered before exercise. The pooled relative effect estimate indicated a 48% reduction (95% CI 33% to 64%) in the postexercise FEV1 decline when vitamin C was administered before exercise. One study needed imputations to include it in the meta-analyses, but it also reported that vitamin C decreased the proportion of participants who suffered from EIB by 50 percentage points (95% CI 23 to 68); this comparison did not need data imputations. Conclusions Given the safety and low cost of vitamin C, and the positive findings for vitamin C administration in the three EIB studies, it seems reasonable for physically active people to test vitamin C when they have respiratory symptoms such as cough associated with exercise. Further research on the effects of vitamin C on EIB is warranted.","language":"en","number":"6","urldate":"2020-03-31","journal":"BMJ Open","author":[{"propositions":[],"lastnames":["Hemilä"],"firstnames":["Harri"],"suffixes":[]}],"month":"June","year":"2013","pmid":"23794586","note":"Publisher: British Medical Journal Publishing Group Section: Respiratory medicine","keywords":"Nutrition & Dietetics, Sports Medicine","pages":"e002416","bibtex":"@article{hemila_vitamin_2013,\n\ttitle = {Vitamin {C} may alleviate exercise-induced bronchoconstriction: a meta-analysis},\n\tvolume = {3},\n\tcopyright = {Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode},\n\tissn = {2044-6055, 2044-6055},\n\tshorttitle = {Vitamin {C} may alleviate exercise-induced bronchoconstriction},\n\turl = {https://bmjopen.bmj.com/content/3/6/e002416},\n\tdoi = {10.1136/bmjopen-2012-002416},\n\tabstract = {Objective To determine whether vitamin C administration influences exercise-induced bronchoconstriction (EIB).\nDesign Systematic review and meta-analysis.\nMethods MEDLINE and Scopus were searched for placebo-controlled trials on vitamin C and EIB. The primary measures of vitamin C effect used in this study were: (1) the arithmetic difference and (2) the relative effect in the postexercise forced expiratory volume in 1 s (FEV1) decline between the vitamin C and placebo periods. The relative effect of vitamin C administration on FEV1 was analysed by using linear modelling for two studies that reported full or partial individual-level data. The arithmetic differences and the relative effects were pooled by the inverse variance method. A secondary measure of the vitamin C effect was the difference in the proportion of participants suffering from EIB on the vitamin C and placebo days.\nResults 3 placebo-controlled trials that studied the effect of vitamin C on EIB were identified. In all, they had 40 participants. The pooled effect estimate indicated a reduction of 8.4 percentage points (95\\% CI 4.6 to 12) in the postexercise FEV1 decline when vitamin C was administered before exercise. The pooled relative effect estimate indicated a 48\\% reduction (95\\% CI 33\\% to 64\\%) in the postexercise FEV1 decline when vitamin C was administered before exercise. One study needed imputations to include it in the meta-analyses, but it also reported that vitamin C decreased the proportion of participants who suffered from EIB by 50 percentage points (95\\% CI 23 to 68); this comparison did not need data imputations.\nConclusions Given the safety and low cost of vitamin C, and the positive findings for vitamin C administration in the three EIB studies, it seems reasonable for physically active people to test vitamin C when they have respiratory symptoms such as cough associated with exercise. Further research on the effects of vitamin C on EIB is warranted.},\n\tlanguage = {en},\n\tnumber = {6},\n\turldate = {2020-03-31},\n\tjournal = {BMJ Open},\n\tauthor = {Hemilä, Harri},\n\tmonth = jun,\n\tyear = {2013},\n\tpmid = {23794586},\n\tnote = {Publisher: British Medical Journal Publishing Group\nSection: Respiratory medicine},\n\tkeywords = {Nutrition \\& Dietetics, Sports Medicine},\n\tpages = {e002416},\n}\n\n","author_short":["Hemilä, H."],"key":"hemila_vitamin_2013","id":"hemila_vitamin_2013","bibbaseid":"hemil-vitamincmayalleviateexerciseinducedbronchoconstrictionametaanalysis-2013","role":"author","urls":{"Paper":"https://bmjopen.bmj.com/content/3/6/e002416"},"keyword":["Nutrition & Dietetics","Sports Medicine"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/ckelleyt","dataSources":["W5PhLT7vuF6ko8d7J","tTydwtpFKyvDpy8qn"],"keywords":["nutrition & dietetics","sports medicine"],"search_terms":["vitamin","alleviate","exercise","induced","bronchoconstriction","meta","analysis","hemilä"],"title":"Vitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis","year":2013}