Behavioral effects of oral subacute exposure to BDE-209 in young adult mice: a preliminary study. Heredia, L., Torrente, M., Colomina, M. T, & Domingo, J. L Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4):707--12, March, 2012.
Behavioral effects of oral subacute exposure to BDE-209 in young adult mice: a preliminary study. [link]Paper  doi  abstract   bibtex   
In this study, we examined the effects of an oral subacute exposure to 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.
@article{heredia_behavioral_2012,
	title = {Behavioral effects of oral subacute exposure to {BDE}-209 in young adult mice: a preliminary study.},
	volume = {50},
	issn = {1873-6351},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22178224},
	doi = {10.1016/j.fct.2011.12.002},
	abstract = {In this study, we examined the effects of an oral subacute exposure to 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.},
	number = {3-4},
	journal = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
	author = {Heredia, Luis and Torrente, Margarita and Colomina, María T and Domingo, José L},
	month = mar,
	year = {2012},
	pmid = {22178224},
	keywords = {Administration, Animal, Animal: drug effects, Animals, Behavior, Body Weight, Body Weight: drug effects, Darkness, Dose-Response Relationship, Drug, Flame Retardants: pharmacology, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: pharmacology, Light, Male, Maze Learning, Mice, Oral, Transgenic},
	pages = {707--12}
}

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