Behavioral effects of oral subacute exposure to BDE-209 in young adult mice: a preliminary study. Heredia, L., Torrente, M., Colomina, M. T, & Domingo, J. L Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4):707–12, March, 2012. Paper doi abstract bibtex In this study, we examined the effects of an oral subacute exposure to 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.
@article{heredia_behavioral_2012,
title = {Behavioral effects of oral subacute exposure to {BDE}-209 in young adult mice: a preliminary study.},
volume = {50},
issn = {1873-6351},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22178224},
doi = {10.1016/j.fct.2011.12.002},
abstract = {In this study, we examined the effects of an oral subacute exposure to 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.},
number = {3-4},
journal = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
author = {Heredia, Luis and Torrente, Margarita and Colomina, María T and Domingo, José L},
month = mar,
year = {2012},
pmid = {22178224},
keywords = {Administration, Animal, Animal: drug effects, Animals, Behavior, Body Weight, Body Weight: drug effects, Darkness, Dose-Response Relationship, Drug, Flame Retardants: pharmacology, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: pharmacology, Light, Male, Maze Learning, Mice, Oral, Transgenic},
pages = {707--12},
}
Downloads: 0
{"_id":"24gWbPixYMLi9wDCx","bibbaseid":"heredia-torrente-colomina-domingo-behavioraleffectsoforalsubacuteexposuretobde209inyoungadultmiceapreliminarystudy-2012","author_short":["Heredia, L.","Torrente, M.","Colomina, M. T","Domingo, J. L"],"bibdata":{"bibtype":"article","type":"article","title":"Behavioral effects of oral subacute exposure to BDE-209 in young adult mice: a preliminary study.","volume":"50","issn":"1873-6351","url":"http://www.ncbi.nlm.nih.gov/pubmed/22178224","doi":"10.1016/j.fct.2011.12.002","abstract":"In this study, we examined the effects of an oral subacute exposure to 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.","number":"3-4","journal":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","author":[{"propositions":[],"lastnames":["Heredia"],"firstnames":["Luis"],"suffixes":[]},{"propositions":[],"lastnames":["Torrente"],"firstnames":["Margarita"],"suffixes":[]},{"propositions":[],"lastnames":["Colomina"],"firstnames":["María","T"],"suffixes":[]},{"propositions":[],"lastnames":["Domingo"],"firstnames":["José","L"],"suffixes":[]}],"month":"March","year":"2012","pmid":"22178224","keywords":"Administration, Animal, Animal: drug effects, Animals, Behavior, Body Weight, Body Weight: drug effects, Darkness, Dose-Response Relationship, Drug, Flame Retardants: pharmacology, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: pharmacology, Light, Male, Maze Learning, Mice, Oral, Transgenic","pages":"707–12","bibtex":"@article{heredia_behavioral_2012,\n\ttitle = {Behavioral effects of oral subacute exposure to {BDE}-209 in young adult mice: a preliminary study.},\n\tvolume = {50},\n\tissn = {1873-6351},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/22178224},\n\tdoi = {10.1016/j.fct.2011.12.002},\n\tabstract = {In this study, we examined the effects of an oral subacute exposure to 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.},\n\tnumber = {3-4},\n\tjournal = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},\n\tauthor = {Heredia, Luis and Torrente, Margarita and Colomina, María T and Domingo, José L},\n\tmonth = mar,\n\tyear = {2012},\n\tpmid = {22178224},\n\tkeywords = {Administration, Animal, Animal: drug effects, Animals, Behavior, Body Weight, Body Weight: drug effects, Darkness, Dose-Response Relationship, Drug, Flame Retardants: pharmacology, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: pharmacology, Light, Male, Maze Learning, Mice, Oral, Transgenic},\n\tpages = {707--12},\n}\n\n\n\n","author_short":["Heredia, L.","Torrente, M.","Colomina, M. T","Domingo, J. L"],"key":"heredia_behavioral_2012","id":"heredia_behavioral_2012","bibbaseid":"heredia-torrente-colomina-domingo-behavioraleffectsoforalsubacuteexposuretobde209inyoungadultmiceapreliminarystudy-2012","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/22178224"},"keyword":["Administration","Animal","Animal: drug effects","Animals","Behavior","Body Weight","Body Weight: drug effects","Darkness","Dose-Response Relationship","Drug","Flame Retardants: pharmacology","Flame retardants","Halogenated Diphenyl Ethers","Halogenated Diphenyl Ethers: pharmacology","Light","Male","Maze Learning","Mice","Oral","Transgenic"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/mdedeo","dataSources":["SSfxPwd7XbkRtnZ9f"],"keywords":["administration","animal","animal: drug effects","animals","behavior","body weight","body weight: drug effects","darkness","dose-response relationship","drug","flame retardants: pharmacology","flame retardants","halogenated diphenyl ethers","halogenated diphenyl ethers: pharmacology","light","male","maze learning","mice","oral","transgenic"],"search_terms":["behavioral","effects","oral","subacute","exposure","bde","209","young","adult","mice","preliminary","study","heredia","torrente","colomina","domingo"],"title":"Behavioral effects of oral subacute exposure to BDE-209 in young adult mice: a preliminary study.","year":2012}