Residual tumor (R) classification and prognosis. Hermanek, P & Wittekind, C Seminars in Surgical Oncology, 10(1):12–20, February, 1994.
Paper abstract bibtex The tumor status following treatment is described by the residual tumor (R) classification: R0, no residual tumor; R1, microscopic residual tumor; R2, macroscopic residual tumor. Residual tumor may be found in the area of primary tumor and its regional lymph nodes and/or at distant sites. The R classification reflects the effects of treatment and influences further treatment planning. Furthermore, the R classification is a strong predictor of prognosis. An acceptable long-term prognosis can be expected only in R0 patients. Although there exist clear correlations between stage and R classification the differences in prognosis of R0 versus R1,2 cannot be explained by differences in stage alone. The prognostic significance of R classification is demonstrated by respective data for non-small cell lung carcinoma, squamous cell carcinoma of oesophagus, gastric carcinoma, ductal adenocarcinoma of the pancreas, colorectal carcinoma, lung and liver metastases.
@article{hermanek_residual_1994,
title = {Residual tumor ({R}) classification and prognosis},
volume = {10},
issn = {8756-0437},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8115781},
abstract = {The tumor status following treatment is described by the residual tumor (R) classification: R0, no residual tumor; R1, microscopic residual tumor; R2, macroscopic residual tumor. Residual tumor may be found in the area of primary tumor and its regional lymph nodes and/or at distant sites. The R classification reflects the effects of treatment and influences further treatment planning. Furthermore, the R classification is a strong predictor of prognosis. An acceptable long-term prognosis can be expected only in R0 patients. Although there exist clear correlations between stage and R classification the differences in prognosis of R0 versus R1,2 cannot be explained by differences in stage alone. The prognostic significance of R classification is demonstrated by respective data for non-small cell lung carcinoma, squamous cell carcinoma of oesophagus, gastric carcinoma, ductal adenocarcinoma of the pancreas, colorectal carcinoma, lung and liver metastases.},
number = {1},
urldate = {2009-10-23},
journal = {Seminars in Surgical Oncology},
author = {Hermanek, P and Wittekind, C},
month = feb,
year = {1994},
pmid = {8115781},
keywords = {Carcinoma, Ductal, Breast, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Colorectal Neoplasms, Confidence Intervals, Epidemiologic Methods, Esophageal Neoplasms, Forecasting, Germany, Humans, Liver Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasms, Pancreatic Neoplasms, Postoperative Period, Prognosis, Stomach Neoplasms, Survival Analysis, Survival Rate},
pages = {12--20},
}
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Although there exist clear correlations between stage and R classification the differences in prognosis of R0 versus R1,2 cannot be explained by differences in stage alone. 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