Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy. Hermann, B P, Seidenberg, M, Schoenfeld, J, & Davies, K Archives of Neurology, 54(4):369–376, April, 1997. ![Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex OBJECTIVE To identify the neuropsychological features of the syndrome of mesial temporal lobe epilepsy (MTLE), a surgically remediable epileptic syndrome defined by the presence of hippocampal sclerosis, using a broad and comprehensive neuropsychological test battery. SETTING Epilepsy surgery center. PATIENTS After scalp adn invasive electroencephalographic monitoring, a consecutive series of 107 adults were found to have intractable complex partial seizures of unilateral left (n = 62) or right (n = 45) temporal lobe origin. Patients were included if they were not retarded and had left hemisphere dominance for speech but no magnetic resonance imaging abnormalities other than hipocampal sclerosis. Histopathological analyses of resected hippocamppi showed that 66 patients had hippocampal sclerosis (MTLE+), and 41 did not have evidence of significant hippocampal sclerosis (MTLE-). INTERVENTIONS None. MAIN DEPENDENT MEASURES: A comprehensive battery of neuropsychological tests that included measures of intelligence, academic achievement, language, visuoperceptual or visuospatial function, memory and learning, attention, and problem-solving abilities. RESULTS The syndrome of MTLE was associated with considerable generalized cognitive impairment (in intelligence, academic achievement, language, and visuospatial functions), but not related to adequacy of performances in other selected cognitive domains (attention or concentration, executive functions). Material-specific memory effects were obtained-primarily for verbal memory in association with left-sided MTLE. CONCLUSIONS Distinct neuropsychological features of spared, compromised, and laterality-specific cognitive impairments characterize the syndrome of MTLE. This information needs to be incorporated into formal syndrome criteria.
@article{hermann_neuropsychological_1997,
title = {Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy},
volume = {54},
issn = {0003-9942},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9109737},
abstract = {OBJECTIVE
To identify the neuropsychological features of the syndrome of mesial temporal lobe epilepsy (MTLE), a surgically remediable epileptic syndrome defined by the presence of hippocampal sclerosis, using a broad and comprehensive neuropsychological test battery.
SETTING
Epilepsy surgery center.
PATIENTS
After scalp adn invasive electroencephalographic monitoring, a consecutive series of 107 adults were found to have intractable complex partial seizures of unilateral left (n = 62) or right (n = 45) temporal lobe origin. Patients were included if they were not retarded and had left hemisphere dominance for speech but no magnetic resonance imaging abnormalities other than hipocampal sclerosis. Histopathological analyses of resected hippocamppi showed that 66 patients had hippocampal sclerosis (MTLE+), and 41 did not have evidence of significant hippocampal sclerosis (MTLE-).
INTERVENTIONS
None. MAIN DEPENDENT MEASURES: A comprehensive battery of neuropsychological tests that included measures of intelligence, academic achievement, language, visuoperceptual or visuospatial function, memory and learning, attention, and problem-solving abilities.
RESULTS
The syndrome of MTLE was associated with considerable generalized cognitive impairment (in intelligence, academic achievement, language, and visuospatial functions), but not related to adequacy of performances in other selected cognitive domains (attention or concentration, executive functions). Material-specific memory effects were obtained-primarily for verbal memory in association with left-sided MTLE.
CONCLUSIONS
Distinct neuropsychological features of spared, compromised, and laterality-specific cognitive impairments characterize the syndrome of MTLE. This information needs to be incorporated into formal syndrome criteria.},
number = {4},
urldate = {2012-03-01},
journal = {Archives of Neurology},
author = {Hermann, B P and Seidenberg, M and Schoenfeld, J and Davies, K},
month = apr,
year = {1997},
pmid = {9109737},
keywords = {Adult, Cognition, Epilepsy, Temporal Lobe, Hippocampus, Humans, Language, Memory, Neuropsychological tests, Sclerosis},
pages = {369--376},
}
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PATIENTS After scalp adn invasive electroencephalographic monitoring, a consecutive series of 107 adults were found to have intractable complex partial seizures of unilateral left (n = 62) or right (n = 45) temporal lobe origin. Patients were included if they were not retarded and had left hemisphere dominance for speech but no magnetic resonance imaging abnormalities other than hipocampal sclerosis. Histopathological analyses of resected hippocamppi showed that 66 patients had hippocampal sclerosis (MTLE+), and 41 did not have evidence of significant hippocampal sclerosis (MTLE-). INTERVENTIONS None. MAIN DEPENDENT MEASURES: A comprehensive battery of neuropsychological tests that included measures of intelligence, academic achievement, language, visuoperceptual or visuospatial function, memory and learning, attention, and problem-solving abilities. RESULTS The syndrome of MTLE was associated with considerable generalized cognitive impairment (in intelligence, academic achievement, language, and visuospatial functions), but not related to adequacy of performances in other selected cognitive domains (attention or concentration, executive functions). Material-specific memory effects were obtained-primarily for verbal memory in association with left-sided MTLE. CONCLUSIONS Distinct neuropsychological features of spared, compromised, and laterality-specific cognitive impairments characterize the syndrome of MTLE. This information needs to be incorporated into formal syndrome criteria.","number":"4","urldate":"2012-03-01","journal":"Archives of Neurology","author":[{"propositions":[],"lastnames":["Hermann"],"firstnames":["B","P"],"suffixes":[]},{"propositions":[],"lastnames":["Seidenberg"],"firstnames":["M"],"suffixes":[]},{"propositions":[],"lastnames":["Schoenfeld"],"firstnames":["J"],"suffixes":[]},{"propositions":[],"lastnames":["Davies"],"firstnames":["K"],"suffixes":[]}],"month":"April","year":"1997","pmid":"9109737","keywords":"Adult, Cognition, Epilepsy, Temporal Lobe, Hippocampus, Humans, Language, Memory, Neuropsychological tests, Sclerosis","pages":"369–376","bibtex":"@article{hermann_neuropsychological_1997,\n\ttitle = {Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy},\n\tvolume = {54},\n\tissn = {0003-9942},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/9109737},\n\tabstract = {OBJECTIVE\n\nTo identify the neuropsychological features of the syndrome of mesial temporal lobe epilepsy (MTLE), a surgically remediable epileptic syndrome defined by the presence of hippocampal sclerosis, using a broad and comprehensive neuropsychological test battery.\n\n\nSETTING\n\nEpilepsy surgery center.\n\n\nPATIENTS\n\nAfter scalp adn invasive electroencephalographic monitoring, a consecutive series of 107 adults were found to have intractable complex partial seizures of unilateral left (n = 62) or right (n = 45) temporal lobe origin. Patients were included if they were not retarded and had left hemisphere dominance for speech but no magnetic resonance imaging abnormalities other than hipocampal sclerosis. Histopathological analyses of resected hippocamppi showed that 66 patients had hippocampal sclerosis (MTLE+), and 41 did not have evidence of significant hippocampal sclerosis (MTLE-).\n\n\nINTERVENTIONS\n\nNone. MAIN DEPENDENT MEASURES: A comprehensive battery of neuropsychological tests that included measures of intelligence, academic achievement, language, visuoperceptual or visuospatial function, memory and learning, attention, and problem-solving abilities.\n\n\nRESULTS\n\nThe syndrome of MTLE was associated with considerable generalized cognitive impairment (in intelligence, academic achievement, language, and visuospatial functions), but not related to adequacy of performances in other selected cognitive domains (attention or concentration, executive functions). Material-specific memory effects were obtained-primarily for verbal memory in association with left-sided MTLE.\n\n\nCONCLUSIONS\n\nDistinct neuropsychological features of spared, compromised, and laterality-specific cognitive impairments characterize the syndrome of MTLE. 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