Quadrivalent Human Papillomavirus Vaccine Effectiveness after 12 Years in Madrid (Spain). Hernandez-Aguado, J. J., Sánchez Torres, D. Á., Martínez Lamela, E., Aguión Gálvez, G., Sanz Espinosa, E., Pérez Quintanilla, A., Martínez-Carrillo, D. A., Ramírez Mena, M., Coronado Martín, P. J., Zapardiel, I., & de la Fuente-Valero, J. 10(3):387.
doi  abstract   bibtex   
A fully government-funded human papillomavirus (HPV) vaccination program started in 2007 in Spain (only 11-14-year-old girls). The first of those vaccinated cohorts, with the quadrivalent vaccine (Gardasil), turned 25 years old in 2018, the age at which cervical cancer screening begins in Spain. The current study could provide the first evidence about the effectiveness of the quadrivalent vaccine against HPV in Spain and the influence of age of vaccination. The present ambispective cohort study, which was conducted on 790 women aged 25 and 26 years old, compares the rate of HPV prevalence and cytologic anomaly according to the vaccination status. The overall infection rate was 40.09% (vaccinated group) vs. 40.6% (non-vaccinated group). There was a significant reduction in the prevalence of HPV 6 (0% vs. 1.3%) and 16 (2.4% vs. 6.1%), and in the prevalence of cytological abnormalities linked to HPV16: Atypical Squamous Cells of Undetermined Significance (ASCUS) (2.04% vs. 14%), Low-grade Squamous Intraepithelial Lesions (LSIL) (2.94% vs. 18.7%) and High-grade Squamous Intraepithelial Lesion (HSIL) (0% vs. 40%), in the vaccinated group vs. the non-vaccinated group. Only one case of HPV11 and two cases of HPV18 were detected. The vaccine effectively reduces the prevalence of vaccine genotypes and cytological anomalies linked to these genotypes.
@article{hernandez-aguado_quadrivalent_2022,
	title = {Quadrivalent Human Papillomavirus Vaccine Effectiveness after 12 Years in Madrid (Spain)},
	volume = {10},
	issn = {2076-393X},
	doi = {10.3390/vaccines10030387},
	abstract = {A fully government-funded human papillomavirus ({HPV}) vaccination program started in 2007 in Spain (only 11-14-year-old girls). The first of those vaccinated cohorts, with the quadrivalent vaccine (Gardasil), turned 25 years old in 2018, the age at which cervical cancer screening begins in Spain. The current study could provide the first evidence about the effectiveness of the quadrivalent vaccine against {HPV} in Spain and the influence of age of vaccination. The present ambispective cohort study, which was conducted on 790 women aged 25 and 26 years old, compares the rate of {HPV} prevalence and cytologic anomaly according to the vaccination status. The overall infection rate was 40.09\% (vaccinated group) vs. 40.6\% (non-vaccinated group). There was a significant reduction in the prevalence of {HPV} 6 (0\% vs. 1.3\%) and 16 (2.4\% vs. 6.1\%), and in the prevalence of cytological abnormalities linked to {HPV}16: Atypical Squamous Cells of Undetermined Significance ({ASCUS}) (2.04\% vs. 14\%), Low-grade Squamous Intraepithelial Lesions ({LSIL}) (2.94\% vs. 18.7\%) and High-grade Squamous Intraepithelial Lesion ({HSIL}) (0\% vs. 40\%), in the vaccinated group vs. the non-vaccinated group. Only one case of {HPV}11 and two cases of {HPV}18 were detected. The vaccine effectively reduces the prevalence of vaccine genotypes and cytological anomalies linked to these genotypes.},
	pages = {387},
	number = {3},
	journaltitle = {Vaccines},
	shortjournal = {Vaccines (Basel)},
	author = {Hernandez-Aguado, Juan J. and Sánchez Torres, Damián Ángel and Martínez Lamela, Esther and Aguión Gálvez, Gema and Sanz Espinosa, Eva and Pérez Quintanilla, Almudena and Martínez-Carrillo, Daniela A. and Ramírez Mena, Mar and Coronado Martín, Pluvio J. and Zapardiel, Ignacio and de la Fuente-Valero, Jesús},
	date = {2022-03-03},
	pmid = {35335019},
	pmcid = {PMC8952248},
	keywords = {{HPV}, quadrivalent vaccine, vaccine},
	file = {Plný text:C\:\\Users\\Miroslava Kuderavá\\Zotero\\storage\\NMFYDQ33\\Hernandez-Aguado et al. - 2022 - Quadrivalent Human Papillomavirus Vaccine Effectiv.pdf:application/pdf},
}

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