Blood flow measurements with radionuclide-labeled particles. Heymann, M.; Payne, B.; Hoffman, J.; and Rudolph, A. Prog Cardiovasc Dis, 20(1):55--79, 1977. bibtex @Article{RSM:Hey77,
author = "M.A. Heymann and B.D. Payne and J.I. Hoffman and A.M.
Rudolph",
title = "Blood flow measurements with radionuclide-labeled
particles.",
journal = "Prog Cardiovasc Dis",
year = "1977",
volume = "20",
number = "1",
pages = "55--79",
robnote = "When appropriately and correctly applied, the
microsphere technique is relatively simple and
extremely accurate. Distribution patterns, both of
total systemic arterial blood flow or venous return as
well as within specific organs, can be measured.
Several techniques have been applied to quantitate flow
using microspheres; the reference sample method is
extremely simple and by far the most accurate of all.
Collection of venous effluent is perhaps more accurate
but requires extensive surgery and is almost certainly
the least physiologic. Other methods used for
quantitation, such as bolus injections of indocyanine
green dye or in fusions of diffusable indicators, are
considerably less accurate and therefore significantly
reduce the reliability of the microsphere technique.
Selection of the appropriate size microspheres allows
for definition of arteriovenous anastomoses as well as
the measurement of organ blood flows and distribution
of blood flow within those organs. In most instances,
smaller microspheres (15mu diameter or 8-10mu diameter)
have significant advantages over larger ones. They are
distributed more like red cells, obstruct less of the
vascular bed, are less variable in size, and can be
given in significantly greater numbers. This latter
point is important, since the statistical criteria need
to be satisfied and the use of small spheres allows for
the more reliable measurement of blood flow to small
organs or to small regions of organs.",
bibdate = "Thu Sep 20 17:40:22 2001",
}