Dual function of the CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides. Höfer, R., Boachon, B., Renault, H., Gavira, C., Miesch, L., Iglesias, J., Ginglinger, J., Allouche, L., Miesch, M., Grec, S., Larbat, R., & Werck, D. Plant physiology, 166(November):1149-1161, 2014. ![Dual function of the CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website doi abstract bibtex Comparative genomics analysis unravels lineage-specific bursts of gene duplications related to the emergence of specialized pathways. The CYP76C subfamily of cytochrome P450 enzymes is specific to Brassicaceae. Two of its members were recently associated with monoterpenol metabolism. This prompted us to investigate the CYP76C subfamily genetic and functional diversification. Our study revealed high rates of CYP76C gene duplication and loss in Brassicaceae, suggesting the association of the CYP76C subfamily with species-specific adaptive functions. Gene differential expression and enzyme functional specialization in Arabidopsis thaliana, including metabolism of different monoterpenols and formation of different products, support this hypothesis. In addition to linalool metabolism, CYP76C1, CYP76C2 and CYP76C4 metabolized herbicides belonging to the class of phenylurea. Their ectopic expression in the whole plant conferred herbicide tolerance. CYP76Cs from A. thaliana thus provide a first example of promiscuous P450 enzymes endowing effective metabolism of both natural and xenobiotic compounds. Our data also suggest that the CYP76C gene family provides a suitable genetic background for a quick evolution of herbicide resistance.
@article{
title = {Dual function of the CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides.},
type = {article},
year = {2014},
pages = {1149-1161},
volume = {166},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/25082892},
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abstract = {Comparative genomics analysis unravels lineage-specific bursts of gene duplications related to the emergence of specialized pathways. The CYP76C subfamily of cytochrome P450 enzymes is specific to Brassicaceae. Two of its members were recently associated with monoterpenol metabolism. This prompted us to investigate the CYP76C subfamily genetic and functional diversification. Our study revealed high rates of CYP76C gene duplication and loss in Brassicaceae, suggesting the association of the CYP76C subfamily with species-specific adaptive functions. Gene differential expression and enzyme functional specialization in Arabidopsis thaliana, including metabolism of different monoterpenols and formation of different products, support this hypothesis. In addition to linalool metabolism, CYP76C1, CYP76C2 and CYP76C4 metabolized herbicides belonging to the class of phenylurea. Their ectopic expression in the whole plant conferred herbicide tolerance. CYP76Cs from A. thaliana thus provide a first example of promiscuous P450 enzymes endowing effective metabolism of both natural and xenobiotic compounds. Our data also suggest that the CYP76C gene family provides a suitable genetic background for a quick evolution of herbicide resistance.},
bibtype = {article},
author = {Höfer, René and Boachon, Benoit and Renault, Hugues and Gavira, Carole and Miesch, Laurence and Iglesias, Juliana and Ginglinger, Jean-François and Allouche, Lionel and Miesch, Michel and Grec, Sebastien and Larbat, Romain and Werck, Daniele},
doi = {10.1104/pp.114.244814},
journal = {Plant physiology},
number = {November}
}
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