A review of quantitative modeling of B cell responses to antigenic challenge. Hickling, T. P., Chen, X., Vicini, P., & Nayak, S. Journal of Pharmacokinetics and Pharmacodynamics, 41(5):445--459, October, 2014. ![A review of quantitative modeling of B cell responses to antigenic challenge [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex A key role of B cells in the mammalian immune response is the generation of antibodies that serve to protect the organism against antigenic challenges. The same process may also be detrimental in the context of autoimmunity. Several modeling approaches have been applied to this aspect of the immune response, from predicting potential epitopes to describing B cells progress through developmental models and simulating antibody production. Here we review some of the modeling techniques, and summarize models that describe different activation mechanisms for B cells, including T cell dependent and independent models. We focus on viral infection as a prototype system, and briefly describe case studies in other disease areas such as bacterial infection and oncology. We single out aspects of the B cell response for which there are current knowledge gaps. We outline areas in need of further research in modeling applications to ultimately produce a “B cell module” for a complete immune response model.
@article{hickling_review_2014,
title = {A review of quantitative modeling of {B} cell responses to antigenic challenge},
volume = {41},
issn = {1567-567X, 1573-8744},
url = {http://link.springer.com/article/10.1007/s10928-014-9388-7},
doi = {10.1007/s10928-014-9388-7},
abstract = {A key role of B cells in the mammalian immune response is the generation of antibodies that serve to protect the organism against antigenic challenges. The same process may also be detrimental in the context of autoimmunity. Several modeling approaches have been applied to this aspect of the immune response, from predicting potential epitopes to describing B cells progress through developmental models and simulating antibody production. Here we review some of the modeling techniques, and summarize models that describe different activation mechanisms for B cells, including T cell dependent and independent models. We focus on viral infection as a prototype system, and briefly describe case studies in other disease areas such as bacterial infection and oncology. We single out aspects of the B cell response for which there are current knowledge gaps. We outline areas in need of further research in modeling applications to ultimately produce a “B cell module” for a complete immune response model.},
language = {en},
number = {5},
urldate = {2015-05-20TZ},
journal = {Journal of Pharmacokinetics and Pharmacodynamics},
author = {Hickling, Timothy P. and Chen, Xiaoying and Vicini, Paolo and Nayak, Satyaprakash},
month = oct,
year = {2014},
keywords = {Affinity maturation, Agent based modeling, B cell receptors, Biochemistry, general, Biomedical Engineering, Differential equations, Epitope recognition, Pharmacology/Toxicology, Pharmacy, T cell dependent activation, Veterinary Medicine},
pages = {445--459}
}
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