@article{
 title = {Relationship between the structures of taxane derivatives and their microtubule polymerization activity},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Cryo-electron microscopy (cryo-EM),Microtubule,Paclitaxel,Polymerization,Taxane},
 volume = {76},
 id = {7d23fb7d-7590-33e4-b74f-f4e0ed63af79},
 created = {2018-02-28T22:42:48.387Z},
 file_attached = {false},
 profile_id = {a39b8b7f-45f4-3d11-94d2-dbc38be2487d},
 last_modified = {2018-02-28T22:42:48.387Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {true},
 abstract = {Paclitaxel (Taxol), one of the most potent anticancer drugs, is a microtubule-stabilizing compound that inhibits microtubule depolymerization within the cell. The structure of paclitaxel is composed of two key elements, a taxane ring and an N-benzoylphenylisoserine side chain at C-13. A number of natural and artificial compounds with taxane skeletons have been isolated, but almost none of their bioactivities have been evaluated. In this study, we focused on compounds having a taxane skeleton structure and examined their effects on tubulin dynamics. Although none of these compounds had an N-benzoylphenylisoserine side chain, three were found to promote tubulin assembly. On the other hand, one compound inhibited tubluin assembly in a way similar to nocodazole. These compounds exhibited novel structureactivity relationships of taxane compounds. © 2012 W. S. Maney  &  Son Ltd.},
 bibtype = {article},
 author = {Hidaka, M. and Koga, T. and Kiyota, H. and Horiguchi, T. and Shi, Q.-W. and Hirose, K. and Uchida, T.},
 journal = {Bioscience, Biotechnology and Biochemistry},
 number = {2}
}

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