@Article{higgins88clustal,
  author    = {D. G. Higgins and P. M. Sharp},
  title     = {{CLUSTAL}: A package for performing multiple sequence alignment on a microcomputer.},
  journal   = {Gene},
  year      = {1988},
  volume    = {73},
  number    = {1},
  pages     = {237--244},
  abstract  = {An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described. The method is based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores, obtained using a fast pairwise alignment algorithm. Then the multiple alignment is achieved from a series of pairwise alignments of clusters of sequences, following the order of branching in the tree. The method is sufficiently fast and economical with memory to be easily implemented on a microcomputer, and yet the results obtained are comparable to those from packages requiring mainframe computer facilities.},
  keywords  = {Amino Acid Sequence; Animals; Base Sequence; Globins; Humans; Microcomputers; Molecular Sequence Data; Phylogeny; RNA, Ribosomal, 5S},
  optmonth  = dec,
  owner     = {Sebastian},
  pmid      = {3243435},
  timestamp = {2006.12.30},
}

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