Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups. Hirose, Y., Aldape, K., Bollen, a., James, C., D., Brat, D., Lamborn, K., Berger, M., & Feuerstein, B., G. The American journal of pathology, 158(3):1137-43, American Society for Investigative Pathology, 3, 2001.
Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups. [pdf]Paper  abstract   bibtex   
Ependymoma occurs most frequently within the central nervous system of children and young adults. We determined relative chromosomal copy-number aberrations in 44 ependymomas using comparative genomic hybridization. The study included 24 intracranial and 20 spinal cord tumors from pediatric and adult patients. Frequent chromosomal aberrations in intracranial tumors were gain of 1q and losses on 6q, 9, and 13. Gain of 1q and loss on 9 were preferentially associated with histological grade 3 tumors. On the other hand, gain on chromosome 7 was recognized almost exclusively in spinal cord tumors, and was associated with various other chromosomal aberrations including frequent loss of 22q. We conclude that cytogenetic analysis of ependymomas may help to classify these tumors and provide leads concerning their initiation and progression. The relationship of these aberrations to patient outcome needs to be addressed.
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 title = {Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups.},
 type = {article},
 year = {2001},
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 keywords = {Adolescent,Adult,Aged,Aneuploidy,Brain Neoplasms,Brain Neoplasms: classification,Brain Neoplasms: genetics,Child,Child, Preschool,Chromosome Aberrations,Cytogenetic Analysis,Ependymoma,Ependymoma: classification,Ependymoma: genetics,Female,Humans,Infant,Male,Middle Aged,Spinal Cord Neoplasms,Spinal Cord Neoplasms: classification,Spinal Cord Neoplasms: genetics},
 pages = {1137-43},
 volume = {158},
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 month = {3},
 publisher = {American Society for Investigative Pathology},
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 abstract = {Ependymoma occurs most frequently within the central nervous system of children and young adults. We determined relative chromosomal copy-number aberrations in 44 ependymomas using comparative genomic hybridization. The study included 24 intracranial and 20 spinal cord tumors from pediatric and adult patients. Frequent chromosomal aberrations in intracranial tumors were gain of 1q and losses on 6q, 9, and 13. Gain of 1q and loss on 9 were preferentially associated with histological grade 3 tumors. On the other hand, gain on chromosome 7 was recognized almost exclusively in spinal cord tumors, and was associated with various other chromosomal aberrations including frequent loss of 22q. We conclude that cytogenetic analysis of ependymomas may help to classify these tumors and provide leads concerning their initiation and progression. The relationship of these aberrations to patient outcome needs to be addressed.},
 bibtype = {article},
 author = {Hirose, Y and Aldape, K and Bollen, a and James, C D and Brat, D and Lamborn, K and Berger, M and Feuerstein, B G},
 journal = {The American journal of pathology},
 number = {3}
}
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