European perspective on human polyomavirus infection, replication and disease in solid organ transplantation. Hirsch, H. H., Babel, N., Comoli, P., Friman, V., Ginevri, F., Jardine, A., Lautenschlager, I., Legendre, C., Midtvedt, K., Munoz, P., Randhawa, P., Rinaldo, C. H., & Wieszek, A. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20 Suppl 7:74--88, September, 2014. doi abstract bibtex Human polyomaviruses (HPyVs) are a growing challenge in immunocompromised patients in view of the increasing number of now 12 HPyV species and their diverse disease potential. Currently, histological evidence of disease is available for BKPyV causing nephropathy and haemorrhagic cystitis, JCPyV causing progressive multifocal leukoencephalopathy and occasionally nephropathy, MCPyV causing Merkel cell carcinoma and TSPyV causing trichodysplasia spinulosa, the last two being proliferative skin diseases. Here, the current role of HPyV in solid organ transplantation (SOT) was reviewed and recommendations regarding screening, monitoring and intervention were made. Pre-transplant screening of SOT donor or recipient for serostatus or active replication is currently not recommended for any HPyV. Post-transplant, however, regular clinical search for skin lesions, including those associated with MCPyV or TSPyV, is recommended in all SOT recipients. Also, regular screening for BKPyV replication (e.g. by plasma viral load) is recommended in kidney transplant recipients. For SOT patients with probable or proven HPyV disease, reducing immunosuppression should be considered to permit regaining of immune control. Antivirals would be desirable for treating proven HPyV disease, but are solely considered as adjunct local treatment of trichodysplasia spinulosa, whereas surgical resection and chemotherapy are key in Merkel cell carcinoma. Overall, the quality of the clinical evidence and the strength of most recommendations are presently limited, but are expected to improve in the coming years.
@article{hirsch_european_2014,
title = {European perspective on human polyomavirus infection, replication and disease in solid organ transplantation.},
volume = {20 Suppl 7},
copyright = {(c) 2014 The Authors Clinical Microbiology and Infection (c) 2014 European Society of Clinical Microbiology and Infectious Diseases.},
issn = {1469-0691 1198-743X},
doi = {10.1111/1469-0691.12538},
abstract = {Human polyomaviruses (HPyVs) are a growing challenge in immunocompromised patients in view of the increasing number of now 12 HPyV species and their diverse disease potential. Currently, histological evidence of disease is available for BKPyV causing nephropathy and haemorrhagic cystitis, JCPyV causing progressive multifocal leukoencephalopathy and occasionally nephropathy, MCPyV causing Merkel cell carcinoma and TSPyV causing trichodysplasia spinulosa, the last two being proliferative skin diseases. Here, the current role of HPyV in solid organ transplantation (SOT) was reviewed and recommendations regarding screening, monitoring and intervention were made. Pre-transplant screening of SOT donor or recipient for serostatus or active replication is currently not recommended for any HPyV. Post-transplant, however, regular clinical search for skin lesions, including those associated with MCPyV or TSPyV, is recommended in all SOT recipients. Also, regular screening for BKPyV replication (e.g. by plasma viral load) is recommended in kidney transplant recipients. For SOT patients with probable or proven HPyV disease, reducing immunosuppression should be considered to permit regaining of immune control. Antivirals would be desirable for treating proven HPyV disease, but are solely considered as adjunct local treatment of trichodysplasia spinulosa, whereas surgical resection and chemotherapy are key in Merkel cell carcinoma. Overall, the quality of the clinical evidence and the strength of most recommendations are presently limited, but are expected to improve in the coming years.},
language = {eng},
journal = {Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
author = {Hirsch, H. H. and Babel, N. and Comoli, P. and Friman, V. and Ginevri, F. and Jardine, A. and Lautenschlager, I. and Legendre, C. and Midtvedt, K. and Munoz, P. and Randhawa, P. and Rinaldo, C. H. and Wieszek, A.},
month = sep,
year = {2014},
pmid = {24476010},
keywords = {*Organ Transplantation, *Transplant Recipients, Epidemiological Monitoring, Europe/epidemiology, Humans, Immunocompromised Host, Immunosuppressive Agents/therapeutic use, Infection Control/methods, Mass Screening, Merkel cell carcinoma, Polyomavirus Infections/diagnosis/*epidemiology/*prevention \& control, PyVAN, nephropathy, polyoma, progressive multifocal leukoencephalopathy, solid organ transplantation, trichodysplasia spinulosa, virus},
pages = {74--88}
}
Downloads: 0
{"_id":"8yP4Hwk2pkz5yx37v","bibbaseid":"hirsch-babel-comoli-friman-ginevri-jardine-lautenschlager-legendre-etal-europeanperspectiveonhumanpolyomavirusinfectionreplicationanddiseaseinsolidorgantransplantation-2014","downloads":0,"creationDate":"2018-02-20T15:51:50.527Z","title":"European perspective on human polyomavirus infection, replication and disease in solid organ transplantation.","author_short":["Hirsch, H. H.","Babel, N.","Comoli, P.","Friman, V.","Ginevri, F.","Jardine, A.","Lautenschlager, I.","Legendre, C.","Midtvedt, K.","Munoz, P.","Randhawa, P.","Rinaldo, C. H.","Wieszek, A."],"year":2014,"bibtype":"article","biburl":"https://api.zotero.org/users/15622/collections/HTSMABRF/items?key=CmkbaMSzICcqq8RIDIpLPL5m&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"European perspective on human polyomavirus infection, replication and disease in solid organ transplantation.","volume":"20 Suppl 7","copyright":"(c) 2014 The Authors Clinical Microbiology and Infection (c) 2014 European Society of Clinical Microbiology and Infectious Diseases.","issn":"1469-0691 1198-743X","doi":"10.1111/1469-0691.12538","abstract":"Human polyomaviruses (HPyVs) are a growing challenge in immunocompromised patients in view of the increasing number of now 12 HPyV species and their diverse disease potential. Currently, histological evidence of disease is available for BKPyV causing nephropathy and haemorrhagic cystitis, JCPyV causing progressive multifocal leukoencephalopathy and occasionally nephropathy, MCPyV causing Merkel cell carcinoma and TSPyV causing trichodysplasia spinulosa, the last two being proliferative skin diseases. Here, the current role of HPyV in solid organ transplantation (SOT) was reviewed and recommendations regarding screening, monitoring and intervention were made. Pre-transplant screening of SOT donor or recipient for serostatus or active replication is currently not recommended for any HPyV. Post-transplant, however, regular clinical search for skin lesions, including those associated with MCPyV or TSPyV, is recommended in all SOT recipients. Also, regular screening for BKPyV replication (e.g. by plasma viral load) is recommended in kidney transplant recipients. For SOT patients with probable or proven HPyV disease, reducing immunosuppression should be considered to permit regaining of immune control. Antivirals would be desirable for treating proven HPyV disease, but are solely considered as adjunct local treatment of trichodysplasia spinulosa, whereas surgical resection and chemotherapy are key in Merkel cell carcinoma. Overall, the quality of the clinical evidence and the strength of most recommendations are presently limited, but are expected to improve in the coming years.","language":"eng","journal":"Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases","author":[{"propositions":[],"lastnames":["Hirsch"],"firstnames":["H.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Babel"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Comoli"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Friman"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Ginevri"],"firstnames":["F."],"suffixes":[]},{"propositions":[],"lastnames":["Jardine"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Lautenschlager"],"firstnames":["I."],"suffixes":[]},{"propositions":[],"lastnames":["Legendre"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Midtvedt"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Munoz"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Randhawa"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Rinaldo"],"firstnames":["C.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Wieszek"],"firstnames":["A."],"suffixes":[]}],"month":"September","year":"2014","pmid":"24476010","keywords":"*Organ Transplantation, *Transplant Recipients, Epidemiological Monitoring, Europe/epidemiology, Humans, Immunocompromised Host, Immunosuppressive Agents/therapeutic use, Infection Control/methods, Mass Screening, Merkel cell carcinoma, Polyomavirus Infections/diagnosis/*epidemiology/*prevention & control, PyVAN, nephropathy, polyoma, progressive multifocal leukoencephalopathy, solid organ transplantation, trichodysplasia spinulosa, virus","pages":"74--88","bibtex":"@article{hirsch_european_2014,\n\ttitle = {European perspective on human polyomavirus infection, replication and disease in solid organ transplantation.},\n\tvolume = {20 Suppl 7},\n\tcopyright = {(c) 2014 The Authors Clinical Microbiology and Infection (c) 2014 European Society of Clinical Microbiology and Infectious Diseases.},\n\tissn = {1469-0691 1198-743X},\n\tdoi = {10.1111/1469-0691.12538},\n\tabstract = {Human polyomaviruses (HPyVs) are a growing challenge in immunocompromised patients in view of the increasing number of now 12 HPyV species and their diverse disease potential. Currently, histological evidence of disease is available for BKPyV causing nephropathy and haemorrhagic cystitis, JCPyV causing progressive multifocal leukoencephalopathy and occasionally nephropathy, MCPyV causing Merkel cell carcinoma and TSPyV causing trichodysplasia spinulosa, the last two being proliferative skin diseases. Here, the current role of HPyV in solid organ transplantation (SOT) was reviewed and recommendations regarding screening, monitoring and intervention were made. Pre-transplant screening of SOT donor or recipient for serostatus or active replication is currently not recommended for any HPyV. Post-transplant, however, regular clinical search for skin lesions, including those associated with MCPyV or TSPyV, is recommended in all SOT recipients. Also, regular screening for BKPyV replication (e.g. by plasma viral load) is recommended in kidney transplant recipients. For SOT patients with probable or proven HPyV disease, reducing immunosuppression should be considered to permit regaining of immune control. Antivirals would be desirable for treating proven HPyV disease, but are solely considered as adjunct local treatment of trichodysplasia spinulosa, whereas surgical resection and chemotherapy are key in Merkel cell carcinoma. Overall, the quality of the clinical evidence and the strength of most recommendations are presently limited, but are expected to improve in the coming years.},\n\tlanguage = {eng},\n\tjournal = {Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},\n\tauthor = {Hirsch, H. H. and Babel, N. and Comoli, P. and Friman, V. and Ginevri, F. and Jardine, A. and Lautenschlager, I. and Legendre, C. and Midtvedt, K. and Munoz, P. and Randhawa, P. and Rinaldo, C. H. and Wieszek, A.},\n\tmonth = sep,\n\tyear = {2014},\n\tpmid = {24476010},\n\tkeywords = {*Organ Transplantation, *Transplant Recipients, Epidemiological Monitoring, Europe/epidemiology, Humans, Immunocompromised Host, Immunosuppressive Agents/therapeutic use, Infection Control/methods, Mass Screening, Merkel cell carcinoma, Polyomavirus Infections/diagnosis/*epidemiology/*prevention \\& control, PyVAN, nephropathy, polyoma, progressive multifocal leukoencephalopathy, solid organ transplantation, trichodysplasia spinulosa, virus},\n\tpages = {74--88}\n}\n\n","author_short":["Hirsch, H. H.","Babel, N.","Comoli, P.","Friman, V.","Ginevri, F.","Jardine, A.","Lautenschlager, I.","Legendre, C.","Midtvedt, K.","Munoz, P.","Randhawa, P.","Rinaldo, C. H.","Wieszek, A."],"key":"hirsch_european_2014","id":"hirsch_european_2014","bibbaseid":"hirsch-babel-comoli-friman-ginevri-jardine-lautenschlager-legendre-etal-europeanperspectiveonhumanpolyomavirusinfectionreplicationanddiseaseinsolidorgantransplantation-2014","role":"author","urls":{},"keyword":["*Organ Transplantation","*Transplant Recipients","Epidemiological Monitoring","Europe/epidemiology","Humans","Immunocompromised Host","Immunosuppressive Agents/therapeutic use","Infection Control/methods","Mass Screening","Merkel cell carcinoma","Polyomavirus Infections/diagnosis/*epidemiology/*prevention & control","PyVAN","nephropathy","polyoma","progressive multifocal leukoencephalopathy","solid organ transplantation","trichodysplasia spinulosa","virus"],"downloads":0},"search_terms":["european","perspective","human","polyomavirus","infection","replication","disease","solid","organ","transplantation","hirsch","babel","comoli","friman","ginevri","jardine","lautenschlager","legendre","midtvedt","munoz","randhawa","rinaldo","wieszek"],"keywords":["*organ transplantation","*transplant recipients","epidemiological monitoring","europe/epidemiology","humans","immunocompromised host","immunosuppressive agents/therapeutic use","infection control/methods","mass screening","merkel cell carcinoma","polyomavirus infections/diagnosis/*epidemiology/*prevention & control","pyvan","nephropathy","polyoma","progressive multifocal leukoencephalopathy","solid organ transplantation","trichodysplasia spinulosa","virus"],"authorIDs":[],"dataSources":["jkBXviaiRQJMcZ96t"]}