Compression-sensitive magnetic resonance elastography. Hirsch, S., Beyer, F., Guo, J., Papazoglou, S., Tzschaetzsch, H., Braun, J., & Sack, I. Phys Med Biol, 58(15):5287--5299, Aug, 2013.
Compression-sensitive magnetic resonance elastography. [link]Paper  doi  abstract   bibtex   
Magnetic resonance elastography (MRE) quantifies the shear modulus of biological tissue to detect disease. Complementary to the shear elastic properties of tissue, the compression modulus may be a clinically useful biomarker because it is sensitive to tissue pressure and poromechanical interactions. In this work, we analyze the capability of MRE to measure volumetric strain and the dynamic bulk modulus (P-wave modulus) at a harmonic drive frequency commonly used in shear-wave-based MRE. Gel phantoms with various densities were created by introducing CO2-filled cavities to establish a compressible effective medium. The dependence of the effective medium's bulk modulus on phantom density was investigated via static compression tests, which confirmed theoretical predictions. The P-wave modulus of three compressible phantoms was calculated from volumetric strain measured by 3D wave-field MRE at 50�Hz drive frequency. The results demonstrate the�MRE-derived volumetric strain and P-wave modulus to be sensitive to the compression properties of effective media. Since the reconstruction of the P-wave modulus requires third-order derivatives, noise remains critical, and P-wave moduli are systematically underestimated. Focusing on relative changes in the effective bulk modulus of tissue, compression-sensitive MRE may be useful for the noninvasive detection of diseases involving pathological pressure alterations such as hepatic hypertension or hydrocephalus.
@article{ Hirsch2013,
  author = {Hirsch, Sebastian and Beyer, Frauke and Guo, Jing and Papazoglou,
	Sebastian and Tzschaetzsch, Heiko and Braun, Juergen and Sack, Ingolf},
  title = {Compression-sensitive magnetic resonance elastography.},
  journal = {Phys Med Biol},
  year = {2013},
  volume = {58},
  pages = {5287--5299},
  number = {15},
  month = {Aug},
  abstract = {Magnetic resonance elastography (MRE) quantifies the shear modulus
	of biological tissue to detect disease. Complementary to the shear
	elastic properties of tissue, the compression modulus may be a clinically
	useful biomarker because it is sensitive to tissue pressure and poromechanical
	interactions. In this work, we analyze the capability of MRE to measure
	volumetric strain and the dynamic bulk modulus (P-wave modulus) at
	a harmonic drive frequency commonly used in shear-wave-based MRE.
	Gel phantoms with various densities were created by introducing CO2-filled
	cavities to establish a compressible effective medium. The dependence
	of the effective medium's bulk modulus on phantom density was investigated
	via static compression tests, which confirmed theoretical predictions.
	The P-wave modulus of three compressible phantoms was calculated
	from volumetric strain measured by 3D wave-field MRE at 50�Hz drive
	frequency. The results demonstrate the�MRE-derived volumetric strain
	and P-wave modulus to be sensitive to the compression properties
	of effective media. Since the reconstruction of the P-wave modulus
	requires third-order derivatives, noise remains critical, and P-wave
	moduli are systematically underestimated. Focusing on relative changes
	in the effective bulk modulus of tissue, compression-sensitive MRE
	may be useful for the noninvasive detection of diseases involving
	pathological pressure alterations such as hepatic hypertension or
	hydrocephalus.},
  doi = {10.1088/0031-9155/58/15/5287},
  institution = {Department of Radiology, Charit�-Universit�tsmedizin Berlin, Campus
	Charit� Mitte, Berlin, Germany.},
  language = {eng},
  medline-pst = {ppublish},
  owner = {Heiko},
  pmid = {23852144},
  timestamp = {2013.07.26},
  url = {http://dx.doi.org/10.1088/0031-9155/58/15/5287}
}

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