Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012. Hoa, L. N. M., Bryant, J. E., Choisy, M., Nguyet, L. A., Bao, N. T., Trang, N. H., Chuc, N. T. K., Toan, T. K., Saito, T., Takemae, N., Horby, P., Wertheim, H., & Fox, A. Epidemiology and infection, 143(14):2959–2964, October, 2015.
doi  abstract   bibtex   
A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI 40) was high and similar for both viruses, with 62.6% [95% confidence interval (CI) 59.4-65.7] against A/Perth/16/2009 and 54.6% (95% CI 51.4-57.8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged \textless5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged \textless5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.
@article{hoa_population_2015,
	title = {Population susceptibility to a variant swine-origin influenza virus {A}({H3N2}) in {Vietnam}, 2011-2012.},
	volume = {143},
	issn = {1469-4409 0950-2688},
	doi = {10.1017/S0950268815000187},
	abstract = {A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This  virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus  circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI 40) was high and similar for both viruses, with 62.6\% [95\% confidence interval (CI) 59.4-65.7] against A/Perth/16/2009 and 54.6\% (95\% CI 51.4-57.8\%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged {\textless}5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged {\textless}5 years; however, cross-reactive immunity in adults would likely limit epidemic  emergence potential.},
	language = {eng},
	number = {14},
	journal = {Epidemiology and infection},
	author = {Hoa, L. N. M. and Bryant, J. E. and Choisy, M. and Nguyet, L. A. and Bao, N. T. and Trang, N. H. and Chuc, N. T. K. and Toan, T. K. and Saito, T. and Takemae, N. and Horby, P. and Wertheim, H. and Fox, A.},
	month = oct,
	year = {2015},
	pmid = {25761949},
	pmcid = {PMC4595856},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Animals, Antibodies, Viral/*blood, Child, Child, Preschool, Female, Hemagglutination Inhibition Tests, Humans, Infant, Infant, Newborn, Influenza A, Influenza A Virus, H3N2 Subtype/*immunology/isolation \& purification, Influenza, Human/epidemiology/*immunology, Male, Middle Aged, Orthomyxoviridae Infections/virology, Reassortant Viruses/*immunology/isolation \& purification, Seroepidemiologic Studies, Sus scrofa/virology, Swine, Swine Diseases/virology, Vietnam/epidemiology, Young Adult, virology (human) and epidemiology, zoonoses},
	pages = {2959--2964},
}

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