Aetiologies of central nervous system infection in Viet Nam: a prospective provincial hospital-based descriptive surveillance study. Ho Dang Trung, N., Le Thi Phuong, T., Wolbers, M., Nguyen Van Minh, H., Nguyen Thanh, V., Van, M. P., Thieu, N. T. V., Van, T. L., Song, D. T., Thi, P. L., Thi Phuong, T. N., Van, C. B., Tang, V., Ngoc Anh, T. H., Nguyen, D., Trung, T. P., Thi Nam, L. N., Kiem, H. T., Thi Thanh, T. N., Campbell, J., Caws, M., Day, J., de Jong, M. D., Van Vinh, C. N., Van Doorn, H. R., Tinh, H. T., Farrar, J., & Schultsz, C. PloS one, 7(5):e37825, 2012. doi abstract bibtex BACKGROUND: Infectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen. METHODS: We conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007-April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology. RESULTS: We recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23%). Mycobacterium tuberculosis was confirmed in 34/617 (6%) adult patients and 11/624 (2%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12%) in adults and to 42/624 (7%) in children. CONCLUSIONS: Zoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam.
@article{ho_dang_trung_aetiologies_2012,
title = {Aetiologies of central nervous system infection in {Viet} {Nam}: a prospective provincial hospital-based descriptive surveillance study.},
volume = {7},
issn = {1932-6203 1932-6203},
doi = {10.1371/journal.pone.0037825},
abstract = {BACKGROUND: Infectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen. METHODS: We conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007-April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology. RESULTS: We recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52\%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24\%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23\%). Mycobacterium tuberculosis was confirmed in 34/617 (6\%) adult patients and 11/624 (2\%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12\%) in adults and to 42/624 (7\%) in children. CONCLUSIONS: Zoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam.},
language = {eng},
number = {5},
journal = {PloS one},
author = {Ho Dang Trung, Nghia and Le Thi Phuong, Tu and Wolbers, Marcel and Nguyen Van Minh, Hoang and Nguyen Thanh, Vinh and Van, Minh Pham and Thieu, Nga Tran Vu and Van, Tan Le and Song, Diep To and Thi, Phuong Le and Thi Phuong, Thao Nguyen and Van, Cong Bui and Tang, Vu and Ngoc Anh, Tuan Hoang and Nguyen, Dong and Trung, Tien Phan and Thi Nam, Lien Nguyen and Kiem, Hao Tran and Thi Thanh, Tam Nguyen and Campbell, James and Caws, Maxine and Day, Jeremy and de Jong, Menno D. and Van Vinh, Chau Nguyen and Van Doorn, H. Rogier and Tinh, Hien Tran and Farrar, Jeremy and Schultsz, Constance},
year = {2012},
pmid = {22662232},
pmcid = {PMC3360608},
keywords = {Adult, Central Nervous System Infections/*epidemiology/*etiology, Child, Child, Preschool, Encephalitis, Viral/epidemiology, Female, Humans, Infant, Male, Meningitis, Bacterial/epidemiology, Meningitis, Viral/epidemiology, Middle Aged, Population Surveillance, Prospective Studies, Vietnam/epidemiology, Young Adult},
pages = {e37825},
}
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T.","Farrar, J.","Schultsz, C."],"year":2012,"bibtype":"article","biburl":"https://api.zotero.org/users/4242995/collections/GEVPECXU/items?key=zD4uWY4xk1YOLS3UQ7bLDMqH&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Aetiologies of central nervous system infection in Viet Nam: a prospective provincial hospital-based descriptive surveillance study.","volume":"7","issn":"1932-6203 1932-6203","doi":"10.1371/journal.pone.0037825","abstract":"BACKGROUND: Infectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen. METHODS: We conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007-April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology. RESULTS: We recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23%). Mycobacterium tuberculosis was confirmed in 34/617 (6%) adult patients and 11/624 (2%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12%) in adults and to 42/624 (7%) in children. CONCLUSIONS: Zoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam.","language":"eng","number":"5","journal":"PloS one","author":[{"propositions":[],"lastnames":["Ho","Dang","Trung"],"firstnames":["Nghia"],"suffixes":[]},{"propositions":[],"lastnames":["Le","Thi","Phuong"],"firstnames":["Tu"],"suffixes":[]},{"propositions":[],"lastnames":["Wolbers"],"firstnames":["Marcel"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen","Van","Minh"],"firstnames":["Hoang"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen","Thanh"],"firstnames":["Vinh"],"suffixes":[]},{"propositions":[],"lastnames":["Van"],"firstnames":["Minh","Pham"],"suffixes":[]},{"propositions":[],"lastnames":["Thieu"],"firstnames":["Nga","Tran","Vu"],"suffixes":[]},{"propositions":[],"lastnames":["Van"],"firstnames":["Tan","Le"],"suffixes":[]},{"propositions":[],"lastnames":["Song"],"firstnames":["Diep","To"],"suffixes":[]},{"propositions":[],"lastnames":["Thi"],"firstnames":["Phuong","Le"],"suffixes":[]},{"propositions":[],"lastnames":["Thi","Phuong"],"firstnames":["Thao","Nguyen"],"suffixes":[]},{"propositions":[],"lastnames":["Van"],"firstnames":["Cong","Bui"],"suffixes":[]},{"propositions":[],"lastnames":["Tang"],"firstnames":["Vu"],"suffixes":[]},{"propositions":[],"lastnames":["Ngoc","Anh"],"firstnames":["Tuan","Hoang"],"suffixes":[]},{"propositions":[],"lastnames":["Nguyen"],"firstnames":["Dong"],"suffixes":[]},{"propositions":[],"lastnames":["Trung"],"firstnames":["Tien","Phan"],"suffixes":[]},{"propositions":[],"lastnames":["Thi","Nam"],"firstnames":["Lien","Nguyen"],"suffixes":[]},{"propositions":[],"lastnames":["Kiem"],"firstnames":["Hao","Tran"],"suffixes":[]},{"propositions":[],"lastnames":["Thi","Thanh"],"firstnames":["Tam","Nguyen"],"suffixes":[]},{"propositions":[],"lastnames":["Campbell"],"firstnames":["James"],"suffixes":[]},{"propositions":[],"lastnames":["Caws"],"firstnames":["Maxine"],"suffixes":[]},{"propositions":[],"lastnames":["Day"],"firstnames":["Jeremy"],"suffixes":[]},{"propositions":["de"],"lastnames":["Jong"],"firstnames":["Menno","D."],"suffixes":[]},{"propositions":[],"lastnames":["Van","Vinh"],"firstnames":["Chau","Nguyen"],"suffixes":[]},{"propositions":[],"lastnames":["Van","Doorn"],"firstnames":["H.","Rogier"],"suffixes":[]},{"propositions":[],"lastnames":["Tinh"],"firstnames":["Hien","Tran"],"suffixes":[]},{"propositions":[],"lastnames":["Farrar"],"firstnames":["Jeremy"],"suffixes":[]},{"propositions":[],"lastnames":["Schultsz"],"firstnames":["Constance"],"suffixes":[]}],"year":"2012","pmid":"22662232","pmcid":"PMC3360608","keywords":"Adult, Central Nervous System Infections/*epidemiology/*etiology, Child, Child, Preschool, Encephalitis, Viral/epidemiology, Female, Humans, Infant, Male, Meningitis, Bacterial/epidemiology, Meningitis, Viral/epidemiology, Middle Aged, Population Surveillance, Prospective Studies, Vietnam/epidemiology, Young Adult","pages":"e37825","bibtex":"@article{ho_dang_trung_aetiologies_2012,\n\ttitle = {Aetiologies of central nervous system infection in {Viet} {Nam}: a prospective provincial hospital-based descriptive surveillance study.},\n\tvolume = {7},\n\tissn = {1932-6203 1932-6203},\n\tdoi = {10.1371/journal.pone.0037825},\n\tabstract = {BACKGROUND: Infectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen. METHODS: We conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007-April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology. RESULTS: We recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52\\%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24\\%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23\\%). Mycobacterium tuberculosis was confirmed in 34/617 (6\\%) adult patients and 11/624 (2\\%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12\\%) in adults and to 42/624 (7\\%) in children. CONCLUSIONS: Zoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {PloS one},\n\tauthor = {Ho Dang Trung, Nghia and Le Thi Phuong, Tu and Wolbers, Marcel and Nguyen Van Minh, Hoang and Nguyen Thanh, Vinh and Van, Minh Pham and Thieu, Nga Tran Vu and Van, Tan Le and Song, Diep To and Thi, Phuong Le and Thi Phuong, Thao Nguyen and Van, Cong Bui and Tang, Vu and Ngoc Anh, Tuan Hoang and Nguyen, Dong and Trung, Tien Phan and Thi Nam, Lien Nguyen and Kiem, Hao Tran and Thi Thanh, Tam Nguyen and Campbell, James and Caws, Maxine and Day, Jeremy and de Jong, Menno D. and Van Vinh, Chau Nguyen and Van Doorn, H. 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