Tracking the establishment of local endemic populations of an emergent enteric pathogen. Holt, K. E., Thieu Nga, T. V., Thanh, D. P., Vinh, H., Kim, D. W., Vu Tra, M. P., Campbell, J. I., Hoang, N. V. M., Vinh, N. T., Minh, P. V., Thuy, C. T., Nga, T. T. T., Thompson, C., Dung, T. T. N., Nhu, N. T. K., Vinh, P. V., Tuyet, P. T. N., Phuc, H. L., Lien, N. T. N., Phu, B. D., Ai, N. T. T., Tien, N. M., Dong, N., Parry, C. M., Hien, T. T., Farrar, J. J., Parkhill, J., Dougan, G., Thomson, N. R., & Baker, S. Proceedings of the National Academy of Sciences of the United States of America, 110(43):17522–17527, October, 2013. doi abstract bibtex Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.
@article{holt_tracking_2013,
title = {Tracking the establishment of local endemic populations of an emergent enteric pathogen.},
volume = {110},
issn = {1091-6490 0027-8424},
doi = {10.1073/pnas.1308632110},
abstract = {Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.},
language = {eng},
number = {43},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
author = {Holt, Kathryn E. and Thieu Nga, Tran Vu and Thanh, Duy Pham and Vinh, Ha and Kim, Dong Wook and Vu Tra, My Phan and Campbell, James I. and Hoang, Nguyen Van Minh and Vinh, Nguyen Thanh and Minh, Pham Van and Thuy, Cao Thu and Nga, Tran Thi Thu and Thompson, Corinne and Dung, Tran Thi Ngoc and Nhu, Nguyen Thi Khanh and Vinh, Phat Voong and Tuyet, Pham Thi Ngoc and Phuc, Hoang Le and Lien, Nguyen Thi Nam and Phu, Bui Duc and Ai, Nguyen Thi Thuy and Tien, Nguyen Manh and Dong, Nguyen and Parry, Christopher M. and Hien, Tran Tinh and Farrar, Jeremy J. and Parkhill, Julian and Dougan, Gordon and Thomson, Nicholas R. and Baker, Stephen},
month = oct,
year = {2013},
pmid = {24082120},
pmcid = {PMC3808646},
keywords = {*Endemic Diseases, *Genetic Variation, Anti-Bacterial Agents/therapeutic use, Child, Child, Preschool, Chromosomes, Bacterial/genetics, Ciprofloxacin/therapeutic use, Dysentery, Bacillary/drug therapy/*epidemiology/microbiology, Evolution, Molecular, Fluoroquinolones/therapeutic use, Genome, Bacterial/genetics, Genomics, Genomics/methods, Geography, Humans, Infant, Molecular Sequence Data, Mutation Rate, Phylogeny, Phylogeography, Sequence Analysis, DNA, Shigella sonnei/classification/*genetics/physiology, Vietnam/epidemiology, drug resistance, enteric disease},
pages = {17522--17527},
}
Downloads: 0
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