@article{
 title = {5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation},
 type = {article},
 year = {2013},
 pages = {3110-3117},
 volume = {4},
 websites = {http://dx.doi.org/10.1039/C3SC51122G,http://pubs.rsc.org/en/content/articlepdf/2013/sc/c3sc51122g},
 publisher = {The Royal Society of Chemistry},
 id = {20748034-ac8d-3c5a-bbd8-0e7821937694},
 created = {2015-10-01T17:17:55.000Z},
 file_attached = {true},
 profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},
 last_modified = {2018-07-09T12:39:48.888Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Hopkinson2013},
 source_type = {Journal Article},
 private_publication = {false},
 abstract = {2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase panel, we compare the inhibitory activities of 5-carboxy-8-hydroxyquinoline (IOX1) and 4-carboxy-8-hydroxyquinoline (4C8HQ) with that of two other commonly used 2OG oxygenase inhibitors, N-oxalylglycine (NOG) and 2,4-pyridinedicarboxylic acid (2,4-PDCA). The results reveal that IOX1 has a broad spectrum of activity, as demonstrated by the inhibition of transcription factor hydroxylases, representatives of all 2OG dependent histone demethylase subfamilies, nucleic acid demethylases and γ-butyrobetaine hydroxylase. Cellular assays show that, unlike NOG and 2,4-PDCA, IOX1 is active against both cytosolic and nuclear 2OG oxygenases without ester derivatisation. Unexpectedly, crystallographic studies on these oxygenases demonstrate that IOX1, but not 4C8HQ, can cause translocation of the active site metal, revealing a rare example of protein ligand-induced metal movement.},
 bibtype = {article},
 author = {Hopkinson, Richard J. and Tumber, Anthony and Yapp, Clarence and Chowdhury, Rasheduzzaman and Aik, Wei Shen and Che, Ka Hing and Li, Xuan Shirley and Kristensen, Jan B.L. and King, Oliver N.F. and Chan, Mun Chiang and Yeoh, Kar Kheng and Choi, Hwanho and Walport, Louise J. and Thinnes, Cyrille C. and Bush, Jacob T. and Lejeune, Clarisse and Rydzik, Anna M. and Rose, Nathan R. and Bagg, Eleanor A. and McDonough, Michael A. and Krojer, Tobias J. and Yue, Wyatt W. and Ng, Stanley S. and Olsen, Lars and Brennan, Paul E. and Oppermann, Udo and Müller, Susanne and Klose, Robert J. and Ratcliffe, Peter J. and Schofield, Christopher J. and Kawamura, Akane},
 doi = {10.1039/c3sc51122g},
 journal = {Chemical Science},
 number = {8}
}

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Unexpectedly, crystallographic studies on these oxygenases demonstrate that IOX1, but not 4C8HQ, can cause translocation of the active site metal, revealing a rare example of protein ligand-induced metal movement.","bibtype":"article","author":"Hopkinson, Richard J. and Tumber, Anthony and Yapp, Clarence and Chowdhury, Rasheduzzaman and Aik, Wei Shen and Che, Ka Hing and Li, Xuan Shirley and Kristensen, Jan B.L. and King, Oliver N.F. and Chan, Mun Chiang and Yeoh, Kar Kheng and Choi, Hwanho and Walport, Louise J. and Thinnes, Cyrille C. and Bush, Jacob T. and Lejeune, Clarisse and Rydzik, Anna M. and Rose, Nathan R. and Bagg, Eleanor A. and McDonough, Michael A. and Krojer, Tobias J. and Yue, Wyatt W. and Ng, Stanley S. and Olsen, Lars and Brennan, Paul E. and Oppermann, Udo and Müller, Susanne and Klose, Robert J. and Ratcliffe, Peter J. and Schofield, Christopher J. and Kawamura, Akane","doi":"10.1039/c3sc51122g","journal":"Chemical Science","number":"8","bibtex":"@article{\n title = {5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation},\n type = {article},\n year = {2013},\n pages = {3110-3117},\n volume = {4},\n websites = {http://dx.doi.org/10.1039/C3SC51122G,http://pubs.rsc.org/en/content/articlepdf/2013/sc/c3sc51122g},\n publisher = {The Royal Society of Chemistry},\n id = {20748034-ac8d-3c5a-bbd8-0e7821937694},\n created = {2015-10-01T17:17:55.000Z},\n file_attached = {true},\n profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},\n last_modified = {2018-07-09T12:39:48.888Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n citation_key = {Hopkinson2013},\n source_type = {Journal Article},\n private_publication = {false},\n abstract = {2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. 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