Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. Howard, S., Berdini, V., Boulstridge, J. A., Carr, M. G., Cross, D. M., Curry, J., Devine, L. A., Early, T. R., Fazal, L., Gill, A. L., Heathcote, M., Maman, S., Matthews, J. E., McMenamin, R. L., Navarro, E. F., O’Brien, M. A., O’Reilly, M., Rees, D. C., Reule, M., Tisi, D., Williams, G., Vinković, M., & Wyatt, P. G. Journal of Medicinal Chemistry, 52(2):379–388, January, 2009.

Paper doi bibtex

@article{howard_fragment-based_2009,
	title = {Fragment-{Based} {Discovery} of the {Pyrazol}-4-yl {Urea} ({AT9283}), a {Multitargeted} {Kinase} {Inhibitor} with {Potent} {Aurora} {Kinase} {Activity}},
	volume = {52},
	issn = {0022-2623, 1520-4804},
	url = {https://pubs.acs.org/doi/10.1021/jm800984v},
	doi = {10.1021/jm800984v},
	language = {en},
	number = {2},
	urldate = {2024-07-17},
	journal = {Journal of Medicinal Chemistry},
	author = {Howard, Steven and Berdini, Valerio and Boulstridge, John A. and Carr, Maria G. and Cross, David M. and Curry, Jayne and Devine, Lindsay A. and Early, Theresa R. and Fazal, Lynsey and Gill, Adrian L. and Heathcote, Michelle and Maman, Sarita and Matthews, Julia E. and McMenamin, Rachel L. and Navarro, Eva F. and O’Brien, Michael A. and O’Reilly, Marc and Rees, David C. and Reule, Matthias and Tisi, Dominic and Williams, Glyn and Vinković, Mladen and Wyatt, Paul G.},
	month = jan,
	year = {2009},
	pages = {379--388},
}

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