Origins and Proliferative States of Human Oligodendrocyte Precursor Cells. Huang, W., Bhaduri, A., Velmeshev, D., Wang, S., Wang, L., Rottkamp, C. A, Alvarez-Buylla, A., Rowitch, D. H, & Kriegstein, A. R Cell, 182(3):594–608.e11, July, 2020. abstract bibtex Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced proliferative potential play important roles in human neurogenesis and gray matter expansion, the mechanisms of human oligodendrogenesis and white matter expansion remain largely unknown. Here, we identify EGFR-expressing ``Pre-OPCs'' that originate from outer radial glial cells (oRGs) and undergo mitotic somal translocation (MST) during division. oRG-derived Pre-OPCs provide an additional source of human cortical oligodendrocyte precursor cells (OPCs) and define a lineage trajectory. We further show that human OPCs undergo consecutive symmetric divisions to exponentially increase the progenitor pool size. Additionally, we find that the OPC-enriched gene, PCDH15, mediates daughter cell repulsion and facilitates proliferation. These findings indicate properties of OPC derivation, proliferation, and dispersion important for human white matter expansion and myelination.
@ARTICLE{Huang2020-zf,
title = "Origins and Proliferative States of Human Oligodendrocyte
Precursor Cells",
author = "Huang, Wei and Bhaduri, Aparna and Velmeshev, Dmitry and Wang,
Shaohui and Wang, Li and Rottkamp, Catherine A and
Alvarez-Buylla, Arturo and Rowitch, David H and Kriegstein,
Arnold R",
abstract = "Human cerebral cortex size and complexity has increased greatly
during evolution. While increased progenitor diversity and
enhanced proliferative potential play important roles in human
neurogenesis and gray matter expansion, the mechanisms of human
oligodendrogenesis and white matter expansion remain largely
unknown. Here, we identify EGFR-expressing ``Pre-OPCs'' that
originate from outer radial glial cells (oRGs) and undergo
mitotic somal translocation (MST) during division. oRG-derived
Pre-OPCs provide an additional source of human cortical
oligodendrocyte precursor cells (OPCs) and define a lineage
trajectory. We further show that human OPCs undergo consecutive
symmetric divisions to exponentially increase the progenitor pool
size. Additionally, we find that the OPC-enriched gene, PCDH15,
mediates daughter cell repulsion and facilitates proliferation.
These findings indicate properties of OPC derivation,
proliferation, and dispersion important for human white matter
expansion and myelination.",
journal = "Cell",
volume = 182,
number = 3,
pages = "594--608.e11",
month = jul,
year = 2020,
keywords = "EGFR; OPC; PCDH15; cortical expansion; oligodendrogenesis;
self-repulsion",
language = "en"
}
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R"],"bibdata":{"bibtype":"article","type":"article","title":"Origins and Proliferative States of Human Oligodendrocyte Precursor Cells","author":[{"propositions":[],"lastnames":["Huang"],"firstnames":["Wei"],"suffixes":[]},{"propositions":[],"lastnames":["Bhaduri"],"firstnames":["Aparna"],"suffixes":[]},{"propositions":[],"lastnames":["Velmeshev"],"firstnames":["Dmitry"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Shaohui"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Li"],"suffixes":[]},{"propositions":[],"lastnames":["Rottkamp"],"firstnames":["Catherine","A"],"suffixes":[]},{"propositions":[],"lastnames":["Alvarez-Buylla"],"firstnames":["Arturo"],"suffixes":[]},{"propositions":[],"lastnames":["Rowitch"],"firstnames":["David","H"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced proliferative potential play important roles in human neurogenesis and gray matter expansion, the mechanisms of human oligodendrogenesis and white matter expansion remain largely unknown. Here, we identify EGFR-expressing ``Pre-OPCs'' that originate from outer radial glial cells (oRGs) and undergo mitotic somal translocation (MST) during division. oRG-derived Pre-OPCs provide an additional source of human cortical oligodendrocyte precursor cells (OPCs) and define a lineage trajectory. We further show that human OPCs undergo consecutive symmetric divisions to exponentially increase the progenitor pool size. Additionally, we find that the OPC-enriched gene, PCDH15, mediates daughter cell repulsion and facilitates proliferation. These findings indicate properties of OPC derivation, proliferation, and dispersion important for human white matter expansion and myelination.","journal":"Cell","volume":"182","number":"3","pages":"594–608.e11","month":"July","year":"2020","keywords":"EGFR; OPC; PCDH15; cortical expansion; oligodendrogenesis; self-repulsion","language":"en","bibtex":"@ARTICLE{Huang2020-zf,\n title = \"Origins and Proliferative States of Human Oligodendrocyte\n Precursor Cells\",\n author = \"Huang, Wei and Bhaduri, Aparna and Velmeshev, Dmitry and Wang,\n Shaohui and Wang, Li and Rottkamp, Catherine A and\n Alvarez-Buylla, Arturo and Rowitch, David H and Kriegstein,\n Arnold R\",\n abstract = \"Human cerebral cortex size and complexity has increased greatly\n during evolution. While increased progenitor diversity and\n enhanced proliferative potential play important roles in human\n neurogenesis and gray matter expansion, the mechanisms of human\n oligodendrogenesis and white matter expansion remain largely\n unknown. Here, we identify EGFR-expressing ``Pre-OPCs'' that\n originate from outer radial glial cells (oRGs) and undergo\n mitotic somal translocation (MST) during division. oRG-derived\n Pre-OPCs provide an additional source of human cortical\n oligodendrocyte precursor cells (OPCs) and define a lineage\n trajectory. We further show that human OPCs undergo consecutive\n symmetric divisions to exponentially increase the progenitor pool\n size. Additionally, we find that the OPC-enriched gene, PCDH15,\n mediates daughter cell repulsion and facilitates proliferation.\n These findings indicate properties of OPC derivation,\n proliferation, and dispersion important for human white matter\n expansion and myelination.\",\n journal = \"Cell\",\n volume = 182,\n number = 3,\n pages = \"594--608.e11\",\n month = jul,\n year = 2020,\n keywords = \"EGFR; OPC; PCDH15; cortical expansion; oligodendrogenesis;\n self-repulsion\",\n language = \"en\"\n}\n\n","author_short":["Huang, W.","Bhaduri, A.","Velmeshev, D.","Wang, S.","Wang, L.","Rottkamp, C. A","Alvarez-Buylla, A.","Rowitch, D. H","Kriegstein, A. 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