Comparison of infantile nystagmus syndrome in achiasmatic zebrafish and humans. Huang, M. Y., Chen, C., Huber-Reggi, S. P, Neuhauss, S. C F, & Straumann, D. Annals of the New York Academy of Sciences, 1233:285–91, September, 2011. ![Comparison of infantile nystagmus syndrome in achiasmatic zebrafish and humans. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Infantile nystagmus syndrome (INS; formerly called congenital nystagmus) is an ocular motor disorder characterized by several typical nystagmus waveforms. To date, restrictions inherent to human research and the absence of a handy animal model have impeded efforts to identify the underlying mechanism of INS. Displaying INS-like spontaneous eye oscillations, achiasmatic zebrafish belladonna (bel) mutants may provide new insights into the mystery of INS. In this study, we demonstrate that these spontaneous eye oscillations match the diagnostic waveforms of INS. As a result, zebrafish bel mutants can be used as an animal model for the study of INS. In zebrafish bel mutants, visual pathway abnormalities may contribute to the spontaneous nystagmus via an inverted signal to the pretectal area. We hypothesized that human INS may also be linked to visual pathway abnormalities (possibly underdiagnosed in INS patients) in a similar way.
@article{Huang2011,
title = {Comparison of infantile nystagmus syndrome in achiasmatic zebrafish and humans.},
volume = {1233},
issn = {1749-6632},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21951006},
doi = {10.1111/j.1749-6632.2011.06150.x},
abstract = {Infantile nystagmus syndrome (INS; formerly called congenital nystagmus) is an ocular motor disorder characterized by several typical nystagmus waveforms. To date, restrictions inherent to human research and the absence of a handy animal model have impeded efforts to identify the underlying mechanism of INS. Displaying INS-like spontaneous eye oscillations, achiasmatic zebrafish belladonna (bel) mutants may provide new insights into the mystery of INS. In this study, we demonstrate that these spontaneous eye oscillations match the diagnostic waveforms of INS. As a result, zebrafish bel mutants can be used as an animal model for the study of INS. In zebrafish bel mutants, visual pathway abnormalities may contribute to the spontaneous nystagmus via an inverted signal to the pretectal area. We hypothesized that human INS may also be linked to visual pathway abnormalities (possibly underdiagnosed in INS patients) in a similar way.},
urldate = {2014-08-13},
journal = {Annals of the New York Academy of Sciences},
author = {Huang, Melody Ying-Yu and Chen, Chieng-Cheng and Huber-Reggi, Sabina P and Neuhauss, Stephan C F and Straumann, Dominik},
month = sep,
year = {2011},
pmid = {21951006},
keywords = {\#nosource, Animals, Disease Models, Animal, Humans, Infant, LIM-Homeodomain Proteins, LIM-Homeodomain Proteins: genetics, Mutation, Nerve Tissue Proteins, Nerve Tissue Proteins: genetics, Nystagmus, Congenital, Nystagmus, Congenital: diagnosis, Nystagmus, Congenital: genetics, Nystagmus, Congenital: physiopathology, OKR, Optic Chiasm, Optic Chiasm: abnormalities, Species Specificity, Syndrome, Transcription Factors, Transcription Factors: genetics, Visual Pathways, Visual Pathways: abnormalities, Visual Pathways: physiopathology, Zebrafish, Zebrafish Proteins, Zebrafish Proteins: genetics, zebrafish},
pages = {285--91},
}
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