Non-steroidal anti-inflammatory drugs and risk of first hospital admission for heart failure in the general population. Huerta, C., Varas-Lorenzo, C., Castellsague, J., & García Rodríguez, L. A. Heart (British Cardiac Society), 92(11):1610--1615, November, 2006. doi abstract bibtex OBJECTIVES: To estimate the risk of a first hospital admission for heart failure (HF) associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). METHODS: Cohort study with a nested case-control analysis based on the UK General Practice Research Database. Overall, 1396 cases of first hospital admission for non-fatal HF were identified (January 1997 to December 2000) and compared with a random sample of 5000 controls. RESULTS: The incidence rate was 2.7/1000 person years. Prior clinical diagnosis of HF was the main independent risk factor triggering a first HF hospitalisation (relative risk 7.3, 95% confidence interval (CI) 6.1 to 8.8). The risk of a first hospital admission for HF associated with current use of NSAIDs was 1.3 (95% CI 1.1 to 1.6) after controlling for major confounding factors. No effects of dose and duration were found. The relative risk in current users of NSAIDs with prior HF was 8.6 (95% CI 5.3 to 13.8) compared with patients who did not use NSAIDs and without prior clinical diagnosis of HF. CONCLUSION: Use of NSAIDs was associated with a small increase in risk of a first hospitalisation for HF. In patients with prior clinical diagnosis of HF, the use of NSAIDs may lead to worsening of pre-existing HF that triggers their hospital admission. This increased risk, although small, may result in considerable public health impact, particularly among the elderly.
@article{huerta_non-steroidal_2006,
title = {Non-steroidal anti-inflammatory drugs and risk of first hospital admission for heart failure in the general population},
volume = {92},
issn = {1468-201X},
doi = {10.1136/hrt.2005.082388},
abstract = {OBJECTIVES: To estimate the risk of a first hospital admission for heart failure (HF) associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs).
METHODS: Cohort study with a nested case-control analysis based on the UK General Practice Research Database. Overall, 1396 cases of first hospital admission for non-fatal HF were identified (January 1997 to December 2000) and compared with a random sample of 5000 controls.
RESULTS: The incidence rate was 2.7/1000 person years. Prior clinical diagnosis of HF was the main independent risk factor triggering a first HF hospitalisation (relative risk 7.3, 95\% confidence interval (CI) 6.1 to 8.8). The risk of a first hospital admission for HF associated with current use of NSAIDs was 1.3 (95\% CI 1.1 to 1.6) after controlling for major confounding factors. No effects of dose and duration were found. The relative risk in current users of NSAIDs with prior HF was 8.6 (95\% CI 5.3 to 13.8) compared with patients who did not use NSAIDs and without prior clinical diagnosis of HF.
CONCLUSION: Use of NSAIDs was associated with a small increase in risk of a first hospitalisation for HF. In patients with prior clinical diagnosis of HF, the use of NSAIDs may lead to worsening of pre-existing HF that triggers their hospital admission. This increased risk, although small, may result in considerable public health impact, particularly among the elderly.},
language = {eng},
number = {11},
journal = {Heart (British Cardiac Society)},
author = {Huerta, C. and Varas-Lorenzo, C. and Castellsague, J. and García Rodríguez, L. A.},
month = nov,
year = {2006},
pmid = {16717069},
pmcid = {PMC1861219},
keywords = {Aged, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Cohort Studies, Female, Great Britain, Heart Failure, Hospitalization, Humans, Male, Risk Factors},
pages = {1610--1615}
}
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METHODS: Cohort study with a nested case-control analysis based on the UK General Practice Research Database. Overall, 1396 cases of first hospital admission for non-fatal HF were identified (January 1997 to December 2000) and compared with a random sample of 5000 controls. RESULTS: The incidence rate was 2.7/1000 person years. Prior clinical diagnosis of HF was the main independent risk factor triggering a first HF hospitalisation (relative risk 7.3, 95% confidence interval (CI) 6.1 to 8.8). The risk of a first hospital admission for HF associated with current use of NSAIDs was 1.3 (95% CI 1.1 to 1.6) after controlling for major confounding factors. No effects of dose and duration were found. The relative risk in current users of NSAIDs with prior HF was 8.6 (95% CI 5.3 to 13.8) compared with patients who did not use NSAIDs and without prior clinical diagnosis of HF. CONCLUSION: Use of NSAIDs was associated with a small increase in risk of a first hospitalisation for HF. In patients with prior clinical diagnosis of HF, the use of NSAIDs may lead to worsening of pre-existing HF that triggers their hospital admission. This increased risk, although small, may result in considerable public health impact, particularly among the elderly.","language":"eng","number":"11","journal":"Heart (British Cardiac Society)","author":[{"propositions":[],"lastnames":["Huerta"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Varas-Lorenzo"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Castellsague"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["García","Rodríguez"],"firstnames":["L.","A."],"suffixes":[]}],"month":"November","year":"2006","pmid":"16717069","pmcid":"PMC1861219","keywords":"Aged, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Cohort Studies, Female, Great Britain, Heart Failure, Hospitalization, Humans, Male, Risk Factors","pages":"1610--1615","bibtex":"@article{huerta_non-steroidal_2006,\n\ttitle = {Non-steroidal anti-inflammatory drugs and risk of first hospital admission for heart failure in the general population},\n\tvolume = {92},\n\tissn = {1468-201X},\n\tdoi = {10.1136/hrt.2005.082388},\n\tabstract = {OBJECTIVES: To estimate the risk of a first hospital admission for heart failure (HF) associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs).\nMETHODS: Cohort study with a nested case-control analysis based on the UK General Practice Research Database. Overall, 1396 cases of first hospital admission for non-fatal HF were identified (January 1997 to December 2000) and compared with a random sample of 5000 controls.\nRESULTS: The incidence rate was 2.7/1000 person years. Prior clinical diagnosis of HF was the main independent risk factor triggering a first HF hospitalisation (relative risk 7.3, 95\\% confidence interval (CI) 6.1 to 8.8). The risk of a first hospital admission for HF associated with current use of NSAIDs was 1.3 (95\\% CI 1.1 to 1.6) after controlling for major confounding factors. No effects of dose and duration were found. The relative risk in current users of NSAIDs with prior HF was 8.6 (95\\% CI 5.3 to 13.8) compared with patients who did not use NSAIDs and without prior clinical diagnosis of HF.\nCONCLUSION: Use of NSAIDs was associated with a small increase in risk of a first hospitalisation for HF. In patients with prior clinical diagnosis of HF, the use of NSAIDs may lead to worsening of pre-existing HF that triggers their hospital admission. This increased risk, although small, may result in considerable public health impact, particularly among the elderly.},\n\tlanguage = {eng},\n\tnumber = {11},\n\tjournal = {Heart (British Cardiac Society)},\n\tauthor = {Huerta, C. and Varas-Lorenzo, C. and Castellsague, J. and García Rodríguez, L. A.},\n\tmonth = nov,\n\tyear = {2006},\n\tpmid = {16717069},\n\tpmcid = {PMC1861219},\n\tkeywords = {Aged, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Cohort Studies, Female, Great Britain, Heart Failure, Hospitalization, Humans, Male, Risk Factors},\n\tpages = {1610--1615}\n}\n\n","author_short":["Huerta, C.","Varas-Lorenzo, C.","Castellsague, J.","García Rodríguez, L. 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