Design, Synthesis and Pharmacology of Cannabimimetic Indoles. Huffman, J. W., Dai, D., Martin, B. R., & Compton, D. R. Bioorganic \& Medicinal Chemistry Letters, 4(4):563--566, February, 1994.
Design, Synthesis and Pharmacology of Cannabimimetic Indoles [link]Paper  doi  abstract   bibtex   
Molecular modeling has been employed to design a new group of cannabimimetic 1-alkyl-2-methyl-3-(1-naphthoyl)indoles. Cannabinoid activity was evaluated in vivo in the mouse and in vitro by determining the binding to the cannabinoid receptor. Maximum activity was found for the 1-butyl, pentyl and hexyl analogs. A rationalization for the alignment of these indoles with traditional cannabinoids is presented.
@article{ huffman_design_1994,
  title = {Design, {Synthesis} and {Pharmacology} of {Cannabimimetic} {Indoles}},
  volume = {4},
  issn = {0960-894X},
  url = {http://www.sciencedirect.com/science/article/pii/S0960894X01801554},
  doi = {10.1016/S0960-894X(01)80155-4},
  abstract = {Molecular modeling has been employed to design a new group of cannabimimetic 1-alkyl-2-methyl-3-(1-naphthoyl)indoles. Cannabinoid activity was evaluated in vivo in the mouse and in vitro by determining the binding to the cannabinoid receptor. Maximum activity was found for the 1-butyl, pentyl and hexyl analogs. A rationalization for the alignment of these indoles with traditional cannabinoids is presented.},
  number = {4},
  urldate = {2013-10-09TZ},
  journal = {Bioorganic \& Medicinal Chemistry Letters},
  author = {Huffman, John W. and Dai, Dong and Martin, Billy R. and Compton, David R.},
  month = {February},
  year = {1994},
  pages = {563--566}
}

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