Design, Synthesis and Pharmacology of Cannabimimetic Indoles. Huffman, J. W., Dai, D., Martin, B. R., & Compton, D. R. Bioorganic \& Medicinal Chemistry Letters, 4(4):563--566, February, 1994.
Paper doi abstract bibtex Molecular modeling has been employed to design a new group of cannabimimetic 1-alkyl-2-methyl-3-(1-naphthoyl)indoles. Cannabinoid activity was evaluated in vivo in the mouse and in vitro by determining the binding to the cannabinoid receptor. Maximum activity was found for the 1-butyl, pentyl and hexyl analogs. A rationalization for the alignment of these indoles with traditional cannabinoids is presented.
@article{ huffman_design_1994,
title = {Design, {Synthesis} and {Pharmacology} of {Cannabimimetic} {Indoles}},
volume = {4},
issn = {0960-894X},
url = {http://www.sciencedirect.com/science/article/pii/S0960894X01801554},
doi = {10.1016/S0960-894X(01)80155-4},
abstract = {Molecular modeling has been employed to design a new group of cannabimimetic 1-alkyl-2-methyl-3-(1-naphthoyl)indoles. Cannabinoid activity was evaluated in vivo in the mouse and in vitro by determining the binding to the cannabinoid receptor. Maximum activity was found for the 1-butyl, pentyl and hexyl analogs. A rationalization for the alignment of these indoles with traditional cannabinoids is presented.},
number = {4},
urldate = {2013-10-09TZ},
journal = {Bioorganic \& Medicinal Chemistry Letters},
author = {Huffman, John W. and Dai, Dong and Martin, Billy R. and Compton, David R.},
month = {February},
year = {1994},
pages = {563--566}
}
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