Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms. Hughes, D. & Andersson, D. I. Nature Reviews Genetics, 16(8):459–471, August, 2015. Number: 8 Publisher: Nature Publishing Group![Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Across the diverse biological systems discussed in this Review, the underlying principles concerning the mechanisms and dynamics of resistance development are similar.Drug resistance has emerged in all biological systems in which drugs are used as a standard therapeutic strategy to control infections or cancer. There is an urgent need not only to develop new drugs to support effective therapy but also to develop a better understanding of the underlying mechanisms and forces that drive resistance development.Large population sizes and/or high mutation rates ensure that the emergence of drug resistance is not limited by mutation supply in HIV, in many bacterial infections or in human cancers. Mutation supply may be a limiting factor for fungal and parasitic infections.Horizontal gene transfer (HGT) from a very broad gene pool substantially contributes to the emergence of drug resistance in bacteria but is absent as a source of genetic variation in the other systems discussed. We currently know very little about the dynamics and trajectories of HGT events and have a very poor ability to make predictions.The study and understanding of the dynamics of growth and competition within complex populations subjected to drug therapy are being advanced by the increasing application of next-generation sequencing technologies.In biological systems in which resistance emergence has long been acknowledged to be a problem (particularly HIV infection and human cancer), therapy with combinations of drugs is standard of care. The systematic use of drug combinations in the treatment of bacterial, fungal and parasitic infections might be the most effective short-term means to slow resistance emergence.
@article{hughes_evolutionary_2015,
title = {Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms},
volume = {16},
copyright = {2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.},
issn = {1471-0064},
shorttitle = {Evolutionary consequences of drug resistance},
url = {https://www.nature.com/articles/nrg3922},
doi = {10.1038/nrg3922},
abstract = {Across the diverse biological systems discussed in this Review, the underlying principles concerning the mechanisms and dynamics of resistance development are similar.Drug resistance has emerged in all biological systems in which drugs are used as a standard therapeutic strategy to control infections or cancer. There is an urgent need not only to develop new drugs to support effective therapy but also to develop a better understanding of the underlying mechanisms and forces that drive resistance development.Large population sizes and/or high mutation rates ensure that the emergence of drug resistance is not limited by mutation supply in HIV, in many bacterial infections or in human cancers. Mutation supply may be a limiting factor for fungal and parasitic infections.Horizontal gene transfer (HGT) from a very broad gene pool substantially contributes to the emergence of drug resistance in bacteria but is absent as a source of genetic variation in the other systems discussed. We currently know very little about the dynamics and trajectories of HGT events and have a very poor ability to make predictions.The study and understanding of the dynamics of growth and competition within complex populations subjected to drug therapy are being advanced by the increasing application of next-generation sequencing technologies.In biological systems in which resistance emergence has long been acknowledged to be a problem (particularly HIV infection and human cancer), therapy with combinations of drugs is standard of care. The systematic use of drug combinations in the treatment of bacterial, fungal and parasitic infections might be the most effective short-term means to slow resistance emergence.},
language = {en},
number = {8},
urldate = {2022-07-02},
journal = {Nature Reviews Genetics},
author = {Hughes, Diarmaid and Andersson, Dan I.},
month = aug,
year = {2015},
note = {Number: 8
Publisher: Nature Publishing Group},
keywords = {unread, ⛔ No INSPIRE recid found},
pages = {459--471},
file = {Full Text PDF:C\:\\Users\\matth\\Zotero\\storage\\UVSLQC6Z\\Hughes and Andersson - 2015 - Evolutionary consequences of drug resistance shar.pdf:application/pdf;Snapshot:C\:\\Users\\matth\\Zotero\\storage\\VA86K2W5\\nrg3922.html:text/html},
}
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