@article{
 title = {Engineered Coiled-Coil Protein Microfibers},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 pages = {3503-3510},
 volume = {15},
 month = {10},
 publisher = {AMER CHEMICAL SOC},
 city = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
 id = {00c15c69-812c-35af-b356-830f2b1e5f38},
 created = {2015-12-14T19:51:26.000Z},
 file_attached = {false},
 profile_id = {3187ec9d-0fcc-3ba2-91e0-3075df9b18c3},
 group_id = {d75e47fd-ff52-3a4b-bf1e-6ebc7e454352},
 last_modified = {2017-03-14T12:30:08.401Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {ISI:000343026600004},
 source_type = {article},
 user_context = {Article},
 private_publication = {false},
 abstract = {The fabrication of de novo proteins able to self-assemble on the nano-
to meso-length scales is critical in the development of protein-based
biomaterials in nanotechnology and medicine. Here we report the design
and characterization of a protein engineered coiled-coil that not only
assembles into microfibers, but also can bind hydrophobic small
molecules. Under ambient conditions, the protein forms fibers with
nanoscale structure possessing large aspect ratios formed by bundles of
a-helical homopentameric assemblies, which further assemble into
mesoscale fibers in the presence of curcumin through aggregation.
Surprisingly, these biosynthesized fibers are able to form in conditions
of remarkably low concentrations. Unlike previously designed coiled-coil
fibers, these engineered protein microfibers can bind the small molecule
curcumin throughout the assembly, serving as a depot for encapsulation
and delivery of other chemical agents within protein-based 3D
microenvironments},
 bibtype = {article},
 author = {Hume, Jasmin and Sun, Jennifer and Jacquet, Rudy and Renfrew, P Douglas and Martin, Jesse A and Bonneau, Richard and Gilchrist, M Lane and Montclare, Jin Kim},
 journal = {BIOMACROMOLECULES},
 number = {10}
}

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