Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study. Humes, D. J., Fleming, K. M., Spiller, R. C., & West, J. Gut, 60(2):219--224, February, 2011. doi abstract bibtex OBJECTIVE: To determine the risk of diverticular perforation associated with current and ever use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists. DESIGN, SETTING AND PARTICIPANTS: Case-control analysis using conditional logistic regression analysis of data from the UK General Practice Research Database. The study involved 899 cases of incident diverticular perforation and 8980 population controls from 1990 to 2005. MAIN OUTCOME MEASURES: Odds ratios (ORs) are presented for perforation associated with use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists. Data were adjusted for smoking, comorbidity, prior abdominal pain and body mass index. RESULTS: A total of 899 patients with an incident diagnosis of perforated diverticular disease were identified. Current use of opiate analgesics (OR=2.16; 95% CI 1.55 to 3.01) and oral corticosteroids (OR=2.74; 95% CI 1.63 to 4.61) was associated with a two- and threefold increase in the risk of diverticular perforation, respectively. Current use of a calcium antagonist and aspirin were not associated with an increased risk of diverticular perforation. Current statin use was associated with a reduction in the risk of perforation (OR=0.44; 95% CI 0.20 to 0.95). CONCLUSION: Perforated diverticular disease is a serious surgical emergency with current opiate analgesics and oral corticosteroids being strongly associated with an increased risk of diverticular perforation.
@article{humes_concurrent_2011,
title = {Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study},
volume = {60},
issn = {1468-3288},
shorttitle = {Concurrent drug use and the risk of perforated colonic diverticular disease},
doi = {10.1136/gut.2010.217281},
abstract = {OBJECTIVE: To determine the risk of diverticular perforation associated with current and ever use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists.
DESIGN, SETTING AND PARTICIPANTS: Case-control analysis using conditional logistic regression analysis of data from the UK General Practice Research Database. The study involved 899 cases of incident diverticular perforation and 8980 population controls from 1990 to 2005.
MAIN OUTCOME MEASURES: Odds ratios (ORs) are presented for perforation associated with use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists. Data were adjusted for smoking, comorbidity, prior abdominal pain and body mass index.
RESULTS: A total of 899 patients with an incident diagnosis of perforated diverticular disease were identified. Current use of opiate analgesics (OR=2.16; 95\% CI 1.55 to 3.01) and oral corticosteroids (OR=2.74; 95\% CI 1.63 to 4.61) was associated with a two- and threefold increase in the risk of diverticular perforation, respectively. Current use of a calcium antagonist and aspirin were not associated with an increased risk of diverticular perforation. Current statin use was associated with a reduction in the risk of perforation (OR=0.44; 95\% CI 0.20 to 0.95).
CONCLUSION: Perforated diverticular disease is a serious surgical emergency with current opiate analgesics and oral corticosteroids being strongly associated with an increased risk of diverticular perforation.},
language = {eng},
number = {2},
journal = {Gut},
author = {Humes, David J. and Fleming, Kate M. and Spiller, Robin C. and West, Joe},
month = feb,
year = {2011},
pmid = {20940283},
keywords = {Aged, Aged, 80 and over, Analgesics, Anti-Inflammatory Agents, Non-Steroidal, Cardiovascular Agents, Comorbidity, Confounding Factors (Epidemiology), Diverticulum, Colon, Drug-Related Side Effects and Adverse Reactions, Epidemiologic Methods, Female, Glucocorticoids, Great Britain, Humans, Intestinal Perforation, Male, Middle Aged},
pages = {219--224}
}
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C.","West, J."],"year":2011,"bibtype":"article","biburl":"http://bibbase.org/zotero/veegee78","bibdata":{"bibtype":"article","type":"article","title":"Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study","volume":"60","issn":"1468-3288","shorttitle":"Concurrent drug use and the risk of perforated colonic diverticular disease","doi":"10.1136/gut.2010.217281","abstract":"OBJECTIVE: To determine the risk of diverticular perforation associated with current and ever use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists. DESIGN, SETTING AND PARTICIPANTS: Case-control analysis using conditional logistic regression analysis of data from the UK General Practice Research Database. The study involved 899 cases of incident diverticular perforation and 8980 population controls from 1990 to 2005. MAIN OUTCOME MEASURES: Odds ratios (ORs) are presented for perforation associated with use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists. Data were adjusted for smoking, comorbidity, prior abdominal pain and body mass index. RESULTS: A total of 899 patients with an incident diagnosis of perforated diverticular disease were identified. Current use of opiate analgesics (OR=2.16; 95% CI 1.55 to 3.01) and oral corticosteroids (OR=2.74; 95% CI 1.63 to 4.61) was associated with a two- and threefold increase in the risk of diverticular perforation, respectively. Current use of a calcium antagonist and aspirin were not associated with an increased risk of diverticular perforation. Current statin use was associated with a reduction in the risk of perforation (OR=0.44; 95% CI 0.20 to 0.95). CONCLUSION: Perforated diverticular disease is a serious surgical emergency with current opiate analgesics and oral corticosteroids being strongly associated with an increased risk of diverticular perforation.","language":"eng","number":"2","journal":"Gut","author":[{"propositions":[],"lastnames":["Humes"],"firstnames":["David","J."],"suffixes":[]},{"propositions":[],"lastnames":["Fleming"],"firstnames":["Kate","M."],"suffixes":[]},{"propositions":[],"lastnames":["Spiller"],"firstnames":["Robin","C."],"suffixes":[]},{"propositions":[],"lastnames":["West"],"firstnames":["Joe"],"suffixes":[]}],"month":"February","year":"2011","pmid":"20940283","keywords":"Aged, Aged, 80 and over, Analgesics, Anti-Inflammatory Agents, Non-Steroidal, Cardiovascular Agents, Comorbidity, Confounding Factors (Epidemiology), Diverticulum, Colon, Drug-Related Side Effects and Adverse Reactions, Epidemiologic Methods, Female, Glucocorticoids, Great Britain, Humans, Intestinal Perforation, Male, Middle Aged","pages":"219--224","bibtex":"@article{humes_concurrent_2011,\n\ttitle = {Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study},\n\tvolume = {60},\n\tissn = {1468-3288},\n\tshorttitle = {Concurrent drug use and the risk of perforated colonic diverticular disease},\n\tdoi = {10.1136/gut.2010.217281},\n\tabstract = {OBJECTIVE: To determine the risk of diverticular perforation associated with current and ever use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists.\nDESIGN, SETTING AND PARTICIPANTS: Case-control analysis using conditional logistic regression analysis of data from the UK General Practice Research Database. The study involved 899 cases of incident diverticular perforation and 8980 population controls from 1990 to 2005.\nMAIN OUTCOME MEASURES: Odds ratios (ORs) are presented for perforation associated with use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists. Data were adjusted for smoking, comorbidity, prior abdominal pain and body mass index.\nRESULTS: A total of 899 patients with an incident diagnosis of perforated diverticular disease were identified. Current use of opiate analgesics (OR=2.16; 95\\% CI 1.55 to 3.01) and oral corticosteroids (OR=2.74; 95\\% CI 1.63 to 4.61) was associated with a two- and threefold increase in the risk of diverticular perforation, respectively. Current use of a calcium antagonist and aspirin were not associated with an increased risk of diverticular perforation. Current statin use was associated with a reduction in the risk of perforation (OR=0.44; 95\\% CI 0.20 to 0.95).\nCONCLUSION: Perforated diverticular disease is a serious surgical emergency with current opiate analgesics and oral corticosteroids being strongly associated with an increased risk of diverticular perforation.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Gut},\n\tauthor = {Humes, David J. and Fleming, Kate M. and Spiller, Robin C. and West, Joe},\n\tmonth = feb,\n\tyear = {2011},\n\tpmid = {20940283},\n\tkeywords = {Aged, Aged, 80 and over, Analgesics, Anti-Inflammatory Agents, Non-Steroidal, Cardiovascular Agents, Comorbidity, Confounding Factors (Epidemiology), Diverticulum, Colon, Drug-Related Side Effects and Adverse Reactions, Epidemiologic Methods, Female, Glucocorticoids, Great Britain, Humans, Intestinal Perforation, Male, Middle Aged},\n\tpages = {219--224}\n}\n\n","author_short":["Humes, D. J.","Fleming, K. M.","Spiller, R. 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