Temporal and spatial association of Streptococcus suis infection in humans and porcine reproductive and respiratory syndrome outbreaks in pigs in northern Vietnam. Huong, V. T. L., Thanh, L. V., Phu, V. D., Trinh, D. T., Inui, K., Tung, N., Oanh, N. T. K., Trung, N. V., Hoa, N. T., Bryant, J. E., Horby, P. W., Kinh, N. V., & Wertheim, H. F. L. Epidemiology and infection, 144(1):35–44, January, 2016. doi abstract bibtex Porcine reproductive and respiratory syndrome (PRRS) outbreaks in pigs are associated with increased susceptibility of pigs to secondary bacterial infections, including Streptococcus suis - an important zoonotic pathogen causing bacterial meningitis in humans. This case-control study examined the association between human S. suis infection and PRRS outbreaks in pigs in northern Vietnam. We included 90 S. suis case-patients and 183 non-S. suis sepsis controls from a referral hospital in Hanoi in 2010, a period of major PRRS epizootics in Vietnam. PRRS exposure was determined using data from the National Centre of Veterinary Diagnosis. By univariate analysis, significantly more S. suis patients were reported residing in or adjacent to a PRRS district compared to controls [odds ratio (OR) 2.82, 95% confidence interval (CI) 1.35-5.89 and OR 3.15, 95% CI 1.62-6.15, respectively]. Only residency in adjacent districts remained significantly associated with risk of S. suis infection after adjusting for sex, occupation, and eating practices. SaTScan analysis showed a possible cluster of S. suis infection in humans around PRRS confirmed locations during the March-August period. The findings indicate an epidemiological association between PRRS in pigs and S. suis infections in humans. Effective strategies to strengthen control of PRRS in pigs may help reduce transmission of S. suis infection to humans.
@article{huong_temporal_2016,
title = {Temporal and spatial association of {Streptococcus} suis infection in humans and porcine reproductive and respiratory syndrome outbreaks in pigs in northern {Vietnam}.},
volume = {144},
issn = {1469-4409 0950-2688},
doi = {10.1017/S0950268815000990},
abstract = {Porcine reproductive and respiratory syndrome (PRRS) outbreaks in pigs are associated with increased susceptibility of pigs to secondary bacterial infections, including Streptococcus suis - an important zoonotic pathogen causing bacterial meningitis in humans. This case-control study examined the association between human S. suis infection and PRRS outbreaks in pigs in northern Vietnam. We included 90 S. suis case-patients and 183 non-S. suis sepsis controls from a referral hospital in Hanoi in 2010, a period of major PRRS epizootics in Vietnam. PRRS exposure was determined using data from the National Centre of Veterinary Diagnosis. By univariate analysis, significantly more S. suis patients were reported residing in or adjacent to a PRRS district compared to controls [odds ratio (OR) 2.82, 95\% confidence interval (CI) 1.35-5.89 and OR 3.15, 95\% CI 1.62-6.15, respectively]. Only residency in adjacent districts remained significantly associated with risk of S. suis infection after adjusting for sex, occupation, and eating practices. SaTScan analysis showed a possible cluster of S. suis infection in humans around PRRS confirmed locations during the March-August period. The findings indicate an epidemiological association between PRRS in pigs and S. suis infections in humans. Effective strategies to strengthen control of PRRS in pigs may help reduce transmission of S. suis infection to humans.},
language = {eng},
number = {1},
journal = {Epidemiology and infection},
author = {Huong, V. T. L. and Thanh, L. V. and Phu, V. D. and Trinh, D. T. and Inui, K. and Tung, N. and Oanh, N. T. K. and Trung, N. V. and Hoa, N. T. and Bryant, J. E. and Horby, P. W. and Kinh, N. V. and Wertheim, H. F. L.},
month = jan,
year = {2016},
pmid = {25997360},
pmcid = {PMC4697300},
keywords = {Animals, Case-control, Disease Outbreaks/*veterinary, Humans, Porcine Reproductive and Respiratory Syndrome/*epidemiology/virology, Porcine respiratory and reproductive syndrome virus/*physiology, Risk Factors, Streptococcal Infections/*epidemiology/microbiology, Streptococcus suis, Streptococcus suis/*physiology, Swine, Vietnam, Vietnam/epidemiology, pigs, porcine reproductive and respiratory syndrome, secondary infection, zoonosis},
pages = {35--44},
}
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