The progression of leaf senescence is gated by the cytosolic arginine pool. Hussain, S., Boussardon, C., & Keech, O. Nature Plants, Nature Publishing Group, June, 2026. ![The progression of leaf senescence is gated by the cytosolic arginine pool [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Leaf senescence aims to degrade cellular components to recover valuable nutrients and reallocate them to other organs1. Once this remobilization is complete, cells undergo a vacuolar-type of programmed cell death2, ultimately leading to the death of the entire organ. But how do cells from a senescing leaf ‘know’ when to die? If the cell death process per se is initiated too early, remobilization may not be completed, rendering it futile. This suggests the presence of a ‘sensing’ mechanism that coordinates the remobilization phase with the onset of cell death during leaf senescence. Here, using Arabidopsis thaliana functional stay-green mutants, we show that senescing cells are wired to metabolically dissipate the cytosolic arginine pool, which otherwise represses the progression of leaf senescence. We propose a model in which a senescing cell uses this pool as a proxy for the completion of nitrogen remobilization and to accurately time the subsequent induction of cell death.
@article{hussain_progression_2026,
title = {The progression of leaf senescence is gated by the cytosolic arginine pool},
copyright = {2026 The Author(s)},
issn = {2055-0278},
url = {https://www.nature.com/articles/s41477-026-02328-2},
doi = {10.1038/s41477-026-02328-2},
abstract = {Leaf senescence aims to degrade cellular components to recover valuable nutrients and reallocate them to other organs1. Once this remobilization is complete, cells undergo a vacuolar-type of programmed cell death2, ultimately leading to the death of the entire organ. But how do cells from a senescing leaf ‘know’ when to die? If the cell death process per se is initiated too early, remobilization may not be completed, rendering it futile. This suggests the presence of a ‘sensing’ mechanism that coordinates the remobilization phase with the onset of cell death during leaf senescence. Here, using Arabidopsis thaliana functional stay-green mutants, we show that senescing cells are wired to metabolically dissipate the cytosolic arginine pool, which otherwise represses the progression of leaf senescence. We propose a model in which a senescing cell uses this pool as a proxy for the completion of nitrogen remobilization and to accurately time the subsequent induction of cell death.},
language = {en},
urldate = {2026-07-07},
journal = {Nature Plants},
publisher = {Nature Publishing Group},
author = {Hussain, Shah and Boussardon, Clément and Keech, Olivier},
month = jun,
year = {2026},
keywords = {Abiotic, Cell fate},
pages = {1--9},
}
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